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Louis S. Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P. M. Damen, Daria Bottai, Marcel A. Behr, Jeroen W. J. van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection
www.plospathogens.org
www.plospathogens.org
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252 667.3323 l
h
f*
465.3354 641.3102 m
474.8598 641.3102 l
h
f*
355.4646 615.3449 m
364.9323 615.3449 l
h
f*
370.148 615.3449 m
379.6157 615.3449 l
h
f*
465.9591 602.3055 m
475.4835 602.3055 l
h
f*
477.7512 602.3055 m
487.2756 602.3055 l
h
f*
298.6583 563.3008 m
308.1827 563.3008 l
h
f*
203.4142 524.2961 m
212.9386 524.2961 l
h
f*
215.1496 524.2961 m
224.674 524.2961 l
h
f*
555.5339 524.2961 m
565.0583 524.2961 l
h
f*
304.6677 485.348 m
314.1921 485.348 l
h
f*
319.3512 485.348 m
328.8756 485.348 l
h
f*
244.5165 420.3213 m
254.0409 420.3213 l
h
f*
256.3087 420.3213 m
265.8331 420.3213 l
h
f*
355.1244 381.3165 m
364.6488 381.3165 l
h
f*
464.0315 368.3339 m
490.3937 368.3339 l
h
f*
487.5024 355.3512 m
497.0268 355.3512 l
h
f*
230.8535 316.3465 m
240.378 316.3465 l
h
f*
485.4047 303.3071 m
494.9291 303.3071 l
h
f*
515.622 277.3417 m
525.1465 277.3417 l
h
f*
524.5795 264.3024 m
534.1039 264.3024 l
h
f*
536.315 264.3024 m
545.8394 264.3024 l
h
f*
455.4709 225.2976 m
464.9953 225.2976 l
h
f*
467.2063 225.2976 m
476.7307 225.2976 l
h
f*
481.8898 225.2976 m
491.4142 225.2976 l
h
f*
443.2819 199.3323 m
452.7496 199.3323 l
h
f*
455.0173 199.3323 m
464.5417 199.3323 l
h
f*
203.4142 160.3276 m
212.9386 160.3276 l
h
f*
378.0283 160.3276 m
387.5528 160.3276 l
h
f*
338.7402 134.3055 m
348.2646 134.3055 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
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1.6951 0 Td
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1.7688 0 Td
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([)Tj
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(22)Tj
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5.4936 0 Td
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[()6()16( )-9(\n)12()18()12()]TJ
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1.4683 0 Td
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(the)Tj
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(24)Tj
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(the)Tj
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(25)Tj
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()Tj
0.83 0.64 0.02 0 k
(27)Tj
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(].)Tj
3.5433 0 Td
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1.7801 0 Td
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-32.0312 -1.3039 Td
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5.8053 0 Td
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1.0147 0 Td
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1.1452 0 Td
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1.0375 0 Td
(outer)Tj
2.3471 0 Td
(membrane)Tj
4.5637 0 Td
(permeability)Tj
5.2498 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(].)Tj
3.2541 0 Td
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4.3937 0 Td
(this)Tj
-33.9021 -1.2983 Td
(system)Tj
2.9366 0 Td
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1.7291 0 Td
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2.4037 0 Td
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1.7858 0 Td
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2.9594 0 Td
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(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
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-32.4734 -1.2983 Td
(substrates)Tj
4.1612 0 Td
(of)Tj
1.0148 0 Td
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1.4683 0 Td
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3.5319 0 Td
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(almost)Tj
2.8856 0 Td
(8%)Tj
1.457 0 Td
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3.7587 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
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-32.6265 -1.3039 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F11 1 Tf
1.3152 0 Td
[()7()14()4()2( )20()1()4(\r)4()7()10(\n)-4()]TJ
/F7 1 Tf
4.8019 0 Td
(genome)Tj
3.4072 0 Td
([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(].)Tj
2.0749 0 Td
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2.2791 0 Td
(notable)Tj
3.1861 0 Td
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3.6567 0 Td
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3.702 0 Td
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1.0374 0 Td
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2.109 0 Td
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4.7168 0 Td
(domains.)Tj
-31.3169 -1.2983 Td
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3.4355 0 Td
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3.9855 0 Td
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1.3833 0 Td
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3.7361 0 Td
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2.0636 0 Td
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1.0148 0 Td
(the)Tj
1.4683 0 Td
(lipase)Tj
2.4718 0 Td
(LipY)Tj
-33.5166 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(])Tj
3.0273 0 Td
(and)Tj
1.7292 0 Td
(PPE10,)Tj
3.084 0 Td
(the)Tj
1.4684 0 Td
(latter)Tj
2.296 0 Td
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1.0148 0 Td
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1.0148 0 Td
[()]TJ
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1.3209 0 Td
[()6()16( )-9(\n)12()18()12()]TJ
/F7 1 Tf
3.9458 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
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2.4775 0 Td
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2.9877 0 Td
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8.4019 0 Td
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3.3845 0 Td
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-33.4769 -1.2982 Td
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(33)Tj
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()Tj
0.83 0.64 0.02 0 k
(36)Tj
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[()]TJ
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1.3323 0 Td
(the)Tj
1.4683 0 Td
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2.228 0 Td
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1.8822 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(,)Tj
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(29)Tj
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(].)Tj
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4.9436 0 Td
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3.7417 0 Td
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2.0579 0 Td
[()]TJ
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(.)Tj
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[()6()16( )-9(\n)12()18()12()]TJ
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3.9458 0 Td
(and)Tj
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[()]TJ
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(.)Tj
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1.3152 0 Td
[()7()14()4()2( )20()1()4(\r)4()7()10(\n)-4()]TJ
/F7 1 Tf
4.8019 0 Td
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(37)Tj
0 g
(].)Tj
2.0749 0 Td
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1.4683 0 Td
[()8()]TJ
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1.7292 0 Td
[()8()]TJ
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2.0069 0 Td
(genes)Tj
2.4434 0 Td
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(Fig)Tj
1.8198 0 Td
(1A)Tj
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(\),)Tj
1.9446 0 Td
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2.6475 0 Td
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3.617 0 Td
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-36.0904 -1.2982 Td
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4.2066 0 Td
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[()]TJ
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(.)Tj
/F11 1 Tf
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[()7()14()4()2( )20()1()4(\r)4()7()10(\n)-4()]TJ
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4.7905 0 Td
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2.4945 0 Td
(CDC1551)Tj
4.1726 0 Td
([)Tj
0.83 0.64 0.02 0 k
(37)Tj
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(].)Tj
2.0693 0 Td
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