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Article Dans Une Revue Blood Année : 2020

Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis

Gaëlle Neveu
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Cyrielle Richard
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Fiona Volpe
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Florian Dupuy
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Patrice Vallin
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Muriel Andrieu
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Audrey Lorthiois
Florence Gazeau
Amanda K.A. Silva
Frédérique Verdier
Catherine Lavazec
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Résumé

Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasites transmission from humans to mosquitoes, are key targets for malaria elimination. Immature gametocytes develop in the human bone marrow parenchyma, where they accumulate around erythroblastic islands. Notably though, the interactions between gametocytes and this hematopoietic niche have not been investigated. Here we identify late erythroblasts as a new host cell for P.falciparum sexual stages and show that gametocytes can fully develop inside these nucleated cells in vitro and in vivo, leading to infectious mature gametocytes within reticulocytes. Strikingly, we found that infection of erythroblasts by gametocytes and parasite-derived extracellular vesicles delay the erythroid differentiation, thereby allowing gametocyte maturation to coincide with the release of their host cell from the bone marrow. Taken together, our findings highlight new mechanisms that are pivotal for the maintenance of immature gametocytes in the bone marrow, and provide further insights on how Plasmodium parasites interfere with erythropoiesis and contribute to anemia in malaria patients.

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Dates et versions

pasteur-02890973 , version 1 (05-01-2021)

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Gaëlle Neveu, Cyrielle Richard, Prativa Kumari Behera, Fiona Volpe, Florian Dupuy, et al.. Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis. Blood, 2020, Online ahead of print (12), pp.1381-1393. ⟨10.1182/blood.2019004746⟩. ⟨pasteur-02890973⟩
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