Search - Archive ouverte HAL Access content directly

Filter your results

24 Results
authFullName_s : Alexandre Bougdour
Image document

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

Dayana C Farhat , Matthew W Bowler , Guillaume Communie , Dominique Pontier , Lucid Belmudes et al.
eLife, 2021, 10, pp.e68312. ⟨10.7554/elife.68312⟩
Journal articles hal-03313548v1

Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.

Alexandre Bougdour , Eric Durandau , Marie-Pierre Brenier-Pinchart , Philippe Ortet , ​mohamed Barakat et al.
Cell Host and Microbe, 2013, 13 (4), pp.489-500. ⟨10.1016/j.chom.2013.03.002⟩
Journal articles hal-00839564v1
Image document

Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression.

Alexandre Bougdour , Isabelle Tardieux , Mohamed-Ali Hakimi
Cellular Microbiology, 2014, 16 (3), pp.334-43. ⟨10.1111/cmi.12255⟩
Journal articles inserm-01068993v1

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

Laurence Braun , Marie-Pierre Brenier-Pinchart , Pierre-Mehdi Hammoudi , Dominique Cannella , Sylvie Kieffer-Jaquinod et al.
Nature Microbiology, 2019, 4 (7), pp.1208-1220. ⟨10.1038/s41564-019-0431-8⟩
Journal articles hal-03094848v1
Image document

Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites.

Alexandre Bougdour , Danièle Maubon , Patricia Baldacci , Philippe Ortet , Olivier Bastien et al.
Journal of Experimental Medicine, 2009, 206 (4), pp.953-66. ⟨10.1084/jem.20082826⟩
Journal articles hal-00389147v1
Image document

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

Christopher Swale , Alexandre Bougdour , Audrey Gnahoui-David , Julie Tottey , Sonia Georgeault et al.
Sci Transl Med, 2019, 11 (517), 11 p. ⟨10.1126/scitranslmed.aax7161⟩
Journal articles inserm-02440382v1

A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

Laurence Braun , Marie-Pierre Brenier-Pinchart , Manickam Yogavel , Aurélie Curt-Varesano , Laurence Curt-Bertini et al.
Journal of Experimental Medicine, 2013, 210 (10), pp.2071-2086. ⟨10.1084/jem.20130103⟩
Journal articles hal-02086241v1
Image document

Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

Fabien Sindikubwabo , Shuai Ding , Tahir Hussain , Philippe Ortet , ​mohamed Barakat et al.
eLife, 2017, 6, pii: e29391. ⟨10.7554/eLife.29391⟩
Journal articles hal-02022719v1
Image document

miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain.

Dominique Cannella , Marie-Pierre Brenier-Pinchart , Laurence Braun , Jason M van Rooyen , Alexandre Bougdour et al.
Cell Reports, 2014, 6 (5), pp.928-37. ⟨10.1016/j.celrep.2014.02.002⟩
Journal articles hal-00980026v1

Crl, a low temperature-induced protein in Escherichia coli that binds directly to the stationary phase sigma subunit of RNA polymerase.

Alexandre Bougdour , Cécile Lelong , Johannes Geiselmann
Journal of Biological Chemistry, 2004, 279 (19), pp.19540-50. ⟨10.1074/jbc.M314145200⟩
Journal articles hal-00173294v1
Image document

Coupling Polar Adhesion with Traction, Spring, and Torque Forces Allows High-Speed Helical Migration of the Protozoan Parasite Toxoplasma

Georgios Pavlou , Bastien Touquet , Luis Vigetti , Patricia Renesto , Alexandre Bougdour et al.
ACS Nano, 2020, 14 (6), pp.7121-7139. ⟨10.1021/acsnano.0c01893⟩
Journal articles hal-02990387v1

Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

Gabrielle Gay , Laurence Braun , Marie-Pierre Brenier-Pinchart , Julien Vollaire , Véronique Josserand et al.
Journal of Experimental Medicine, 2016, 213 (9), pp.1779-1798. ⟨10.1084/jem.20160340⟩
Journal articles hal-02086302v1
Image document

The $Toxoplasma$ effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages

Arne L. ten Hoeve , Laurence Braun , Matias E Rodriguez , Gabriela C Olivera , Alexandre Bougdour et al.
Cell Host & Microbe, 2022, 30, pp.1570 - 1588. ⟨10.1016/j.chom.2022.10.001⟩
Journal articles hal-03862330v1
Image document

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

Huan He , Marie-Pierre Brenier-Pinchart , Laurence Braun , Alexandra Kraut , Bastien Touquet et al.
eLife, 2018, 7, pp.e39887. ⟨10.7554/eLife.39887⟩
Journal articles inserm-02440386v1

A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment

Dayana Farhat , Christopher Swale , Céline Dard , Dominique Cannella , Philippe Ortet et al.
Nature Microbiology, 2020, 5 (4), pp.570-583. ⟨10.1038/s41564-020-0674-4⟩
Journal articles hal-02551175v1
Image document

Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase

Christopher Swale , Valeria Bellini , Matthew Bowler , Nardella Flore , Marie-Pierre Brenier-Pinchart et al.
Science Translational Medicine, 2022, 14 (656), 17 p. ⟨10.1126/scitranslmed.abn3231⟩
Journal articles hal-03752215v1

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls very efficiently Cryptosporidium infection

Christopher Swale , Alexandre Bougdour , Audrey Gnahoui-David , Julie Tottey , Sonia Georgeault et al.
ApiCOWplexa 2019. 5. International Meeting on Apicomplexan Parasites in Farm Animals, Oct 2019, Berlin, Germany
Conference papers hal-03307486v1

Chromatin modifications: implications in the regulation of gene expression in Toxoplasma gondii.

Alexandre Bougdour , Laurence Braun , Dominique Cannella , Mohamed-Ali Hakimi
Cellular Microbiology, 2010, 12 (4), pp.413-23. ⟨10.1111/j.1462-5822.2010.01446.x⟩
Journal articles hal-00476865v1
Image document

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist

Erika Pellegrini , Andres Palencia , Laurence Braun , Ulrike Kapp , Alexandre Bougdour et al.
Structure (London, England : 1993), 2017, 25 (1), pp.16-26. ⟨10.1016/j.str.2016.10.011⟩
Journal articles hal-01691846v1

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

Huan He , Marie-Pierre Brenier-Pinchart , Laurence Braun , Alexandra Kraut , Bastien Touquet et al.
Journal articles hal-02083708v1
Image document

ATAD2 controls chromatin-bound HIRA turnover

Tao Wang , Daniel Perazza , Fayçal Boussouar , Matteo Cattaneo , Alexandre Bougdour et al.
Life Science Alliance, 2021, ⟨10.26508/lsa.202101151⟩
Journal articles hal-03359419v1
Image document

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

Laurence Braun , Marie-Pierre Brenier-Pinchart , Pierre-Mehdi Hammoudi , Dominique Cannella , Sylvie Kieffer-Jaquinod et al.
Nature Microbiology, 2019, 4 (7), pp.1208-1220. ⟨10.1038/s41564-019-0431-8⟩
Journal articles inserm-02440385v1

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

Christopher Swale , Valeria Bellini , Matthew Bowler , Flore Nardella , Marie-Pierre Brenier-Pinchart et al.
2021
Preprints, Working Papers, ... hal-03414875v1
Image document

Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites

Valeria Bellini , Christopher Swale , Marie-Pierre Brenier-Pinchart , Tiffany Pezier , Sonia Georgeault et al.
iScience, 2020, 23 (12), 14 p. ⟨10.1016/j.isci.2020.101871⟩
Journal articles hal-03106392v1