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authFullName_s : Béatrice Josselin

Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]Isoquinolines

Mathilde Defois , Chloé Rémondin , Béatrice Josselin , Lionel Nauton , Vincent Théry et al.
Molecules, 2022, 27 (17), pp.5578. ⟨10.3390/molecules27175578⟩
Journal articles hal-03765284v1
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Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1

Mohamed Benchekroun , Ludmila Ermolenko , Minh Quan Tran , Agathe Vagneux , Hristo Nedev et al.
European Journal of Medicinal Chemistry, 2020, 201, pp.112337. ⟨10.1016/j.ejmech.2020.112337⟩
Journal articles hal-03004425v2
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Synthesis and biological evaluation of Haspin inhibitors: kinase inhibitory potency and cellular activity

Wael Zeinyeh , Yannick Esvan , Béatrice Josselin , Mathilde Defois , Blandine Baratte et al.
European Journal of Medicinal Chemistry, 2022, 236, pp.114369. ⟨10.1016/j.ejmech.2022.114369⟩
Journal articles hal-03764791v1

Synthesis and kinase inhibitory potencies of new pyrido[3,4-g]quinazolines substituted at the 8-position

Yannick Esvan , Béatrice Josselin , Blandine Baratte , Stéphane Bach , Sandrine Ruchaud et al.
ARKIVOC - Online Journal of Organic Chemistry, 2020, 2020 (7), pp.105-116. ⟨10.24820/ark.5550190.p011.268⟩
Journal articles hal-02926291v1
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New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

Helmi Tazarki , Wael Zeinyeh , Yannick J. Esvan , Stefan Knapp , Deep Chatterjee et al.
European Journal of Medicinal Chemistry, 2019, 166, pp.304-317. ⟨10.1016/j.ejmech.2019.01.052⟩
Journal articles hal-02150788v1

Synthesis and evaluation of C3 substituted chalcone‐based derivatives of 7‐azaindole as protein kinase inhibitors

Malikotsi Qhobosheane , Lesetja Legoabe , Béatrice Josselin , Stéphane Bach , Sandrine Ruchaud et al.
Chemical Biology and Drug Design, In press, ⟨10.1111/cbdd.13748⟩
Journal articles hal-02906292v1
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Design and biological evaluation of substituted 5,7-dihydro-6 H -indolo[2,3- c ]quinolin-6-one as novel selective Haspin inhibitors

Sreenivas Avula , Xudan Peng , Xingfen Lang , Micky Tortorella , Béatrice Josselin et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37 (1), pp.1632-1650. ⟨10.1080/14756366.2022.2082419⟩
Journal articles hal-03818922v1

Synthesis and biological evaluation of selected 7-azaindole derivatives as CDK9/Cyclin T and Haspin inhibitors

Lianie Pieterse , Lesetja J Legoabe , Richard M Beteck , Béatrice Josselin , Stéphane Bach et al.
Medicinal Chemistry Research, 2020, 29, pp.1449 - 1462. ⟨10.1007/s00044-020-02560-1⟩
Journal articles hal-03868372v1
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Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Killian Oukoloff , Nicolas Coquelle , Manuela Bartolini , Marina Naldi , Rémy Le Guével et al.
European Journal of Medicinal Chemistry, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩
Journal articles hal-02055769v1

Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors

Malikotsi A Qhobosheane , Lesetja J Legoabe , Béatrice Josselin , Stéphane Bach , Sandrine Ruchaud et al.
Bioorganic & Medicinal Chemistry Letters, 2020, 28 (11), pp.115468. ⟨10.1016/j.bmc.2020.115468⟩
Journal articles hal-03869358v1
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Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency

Nada Ibrahim , Pascal Bonnet , Jean-Daniel Brion , Jean-François Peyrat , Jerome Bignon et al.
European Journal of Medicinal Chemistry, 2020, 199 (31), pp.112355. ⟨10.1016/j.ejmech.2020.112355⟩
Journal articles hal-03036489v1
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Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies

Waël Zeinyeh , Yannick Esvan , Béatrice Josselin , Blandine Baratte , Stéphane Bach et al.
Bioorganic and Medicinal Chemistry, 2019, 27 (10), pp.2083-2089. ⟨10.1016/j.bmc.2019.04.005⟩
Journal articles hal-02164744v1
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Design of new disubstituted imidazo[1,2- b ]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

Jonathan Elie , Omid Feizbakhsh , Nathalie Desban , Béatrice Josselin , Blandine Baratte et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.1840-1853. ⟨10.1080/14756366.2020.1825408⟩
Journal articles hal-03004407v1