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authFullName_s : Benoît Gigant
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Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism

Paloma Fernadez-Varela , Mélanie Chenon , Christophe Velours , Kristen J. Verhey , Julie Ménétrey et al.
FEBS Open Bio, 2021, ⟨10.1002/2211-5463.13101⟩
Journal articles hal-03400613v1
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GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation

Rie Ayukawa , Seigo Iwata , Hiroshi Imai , Shinji Kamimura , Masahito Hayashi et al.
Journal of Cell Biology, 2021, 220, ⟨10.1083/jcb.202007033⟩
Journal articles hal-03423264v1

The 4 Å X-Ray Structure of a Tubulin:Stathmin-like Domain Complex

Benoît Gigant , Patrick A. Curmi , Carole Martin-Barbey , Elodie Charbaut , Sylvie Lachkar et al.
Cell, 2000, 102 (6), pp.809-816. ⟨10.1016/s0092-8674(00)00069-6⟩
Journal articles hal-02361490v1

Crystallization and preliminary X-ray diffraction studies of complexes between an influenza hemagglutinin and fab fragments of two different monoclonal antibodies

Benoît Gigant , Damien Fleury , Thierry Bizebard , John Skehel , Marcel Knossow et al.
Proteins: Structure, Function, and Genetics, 1995, 23 (1), pp.115-117. ⟨10.1002/prot.340230113⟩
Journal articles istex hal-02110563v1

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

Timothée Naret , Ilhem Khelifi , Olivier Provot , Jérôme Bignon , Hélène Lévaique et al.
Journal of Medicinal Chemistry, 2019, 62 (4), pp.1902-1916. ⟨10.1021/acs.jmedchem.8b01386⟩
Journal articles hal-02123778v1

Mechanism of microtubule stabilization by taccalonolide AJ

Yuxi Wang , Yamei Yu , Guo-Bo Li , Shu-Ang Li , Chengyong Wu et al.
Nature Communications, 2017, 8, pp.15787. ⟨10.1038/ncomms15787⟩
Journal articles hal-02104497v1

The PN2-3 Domain of Centrosomal P4.1-associated Protein Implements a Novel Mechanism for Tubulin Sequestration

Anthony Cormier , Marie-Jeanne Clément , Marcel Knossow , Sylvie Lachkar , Philippe Savarin et al.
Journal of Biological Chemistry, 2009, 284 (11), pp.6909-6917. ⟨10.1074/jbc.M808249200⟩
Journal articles hal-02120593v1

The structural switch of nucleotide-free kinesin

Luyan Cao , Soraya Cantos-Fernandes , Benoît Gigant
Scientific Reports, 2017, 7 (1), pp.42558. ⟨10.1038/srep42558⟩
Journal articles hal-02123768v1

Structural basis for the regulation of tubulin by vinblastine

Benoît Gigant , Chunguang Wang , Raimond Ravelli , Fanny Roussi , Michel O. Steinmetz et al.
Nature, 2005, 435 (7041), pp.519-522. ⟨10.1038/nature03566⟩
Journal articles istex hal-02119489v1

Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy.

Benoît Gigant , Isabelle Landrieu , Caroline Fauquant , Pascale Barbier , Isabelle Huvent et al.
Journal of the American Chemical Society, 2014, pp.12615-23
Journal articles hal-01077829v1

Structure of influenza virus haemagglutinin complexed with a neutralizing antibody

Thierry Bizebard , Benoît Gigant , Pascal Rigolet , Bjarne Rasmussen , Olivier Diat et al.
Nature, 1995, 376 (6535), pp.92-94. ⟨10.1038/376092a0⟩
Journal articles istex hal-02111431v1

Bases structurales de la régulation de la tubuline par un médicament anticancéreux, la vinblastine

Benoît Gigant , Chunguang Wang , Raimond Ravelli , Marcel Knossow
médecine/sciences, 2005, 21 (10), pp.814-815. ⟨10.1051/medsci/20052110814⟩
Journal articles hal-02111440v1

A synergistic relationship between three regions of stathmin family proteins is required for the formation of a stable complex with tubulin

Isabelle Jourdain , Sylvie Lachkar , Elodie Charbaut , Benoît Gigant , Marcel Knossow et al.
Biochemical Journal, 2004, 378 (3), pp.877-888. ⟨10.1042/BJ20031413⟩
Journal articles hal-02118404v1

The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin

Agata Nawrotek , Marcel Knossow , Benoît Gigant
Journal of Molecular Biology, 2011, 412 (1), pp.35-42. ⟨10.1016/j.jmb.2011.07.029⟩
Journal articles hal-02120600v1

Variations in the colchicine-binding domain provide insight into the structural switch of tubulin

Audrey Dorleans , Benoît Gigant , Raimond Ravelli , Patrick Mailliet , Vincent Mikol et al.
Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (33), pp.13775-13779. ⟨10.1073/pnas.0904223106⟩
Journal articles hal-02120597v1

Insight into the GTPase Activity of Tubulin from Complexes with Stathmin-like Domains

Chunguang Wang , Anthony Cormier , Benoît Gigant , Marcel Knossow
Biochemistry, 2007, 46 (37), pp.10595-10602. ⟨10.1021/bi701147f⟩
Journal articles istex hal-02119493v1

A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end

Ludovic Pecqueur , Christian Duellberg , Birgit Dreier , Qiyang Jiang , Chunguang Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (30), pp.12011-12016. ⟨10.1073/pnas.1204129109⟩
Journal articles hal-02121638v1

New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C.

Weiyi Wang , Ting Shen , Raphaël Guérois , Fuming Zhang , Hureshitanmu Kuerban et al.
Journal of Biological Chemistry, 2015, 290 (30), pp.18721-31. ⟨10.1074/jbc.M115.646919⟩
Journal articles hal-01446760v1
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Elucidating Tau function and dysfunction in the era of cryo-EM

Guy Lippens , Benoît Gigant
Journal of Biological Chemistry, In press, 294 (24), pp.9316-9325. ⟨10.1074/jbc.REV119.008031⟩
Journal articles hal-02137974v1

The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly.

Maud Hertzog , Carine van Heijenoort , Dominique Didry , Martin Gaudier , Jérôme Coutant et al.
Cell, 2004, 117 (5), pp.611-23. ⟨10.1016/S0092-8674(04)00403-9⟩
Journal articles hal-00121857v1

The Binding of Vinca Domain Agents to Tubulin

Anthony Cormier , Marcel Knossow , Chunguang Wang , Benoît Gigant
Microtubules, in vitro, pp.373-390, 2010
Book sections hal-02117601v1

X-Ray structures of two families of hydrolytic antibodies

Benoît Gigant , Jean-Baptiste Charbonnier , Béatrice Golinelli-Pimpaneau , Z. Eshhar , Bernard Green et al.
Applied Biochemistry and Biotechnology, 1998, 75 (1), pp.25-32. ⟨10.1007/BF02787706⟩
Journal articles istex hal-02109618v1

Catalytic Antibodies

Benoît Gigant , Marcel Knossow
John Wiley & Sons, Ltd, 2001, Encyclopedia of Life Sciences
Books hal-02117635v1

Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization.

Weiyi Wang , Qiyang Jiang , Manuela Argentini , David Cornu , Benoît Gigant et al.
Journal of Biological Chemistry, 2012, 287 (18), pp.15143-53. ⟨10.1074/jbc.M111.317859⟩
Journal articles hal-00741318v1

Structure of a kinesin–tubulin complex and implications for kinesin motility

Benoît Gigant , Weiyi Wang , Birgit Dreier , Qiyang Jiang , Ludovic Pecqueur et al.
Nature Structural and Molecular Biology, 2013, 20 (8), pp.1001-1007. ⟨10.1038/nsmb.2624⟩
Journal articles hal-02121652v1

Neither phosphorylation nor the amino-terminal part of rabies virus phosphoprotein is required for its oligomerization

Benoît Gigant , Frédéric Iseni , Yves Gaudin , Marcel Knossow , Danielle Blondel et al.
Journal of General Virology, 2000, 81 (7), pp.1757-1761. ⟨10.1099/0022-1317-81-7-1757⟩
Journal articles hal-02118375v1

Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin

Shoeb Ahmad , Ludovic Pecqueur , Birgit Dreier , Djemel Hamdane , Magali Aumont-Nicaise et al.
Scientific Reports, 2016, 6, ⟨10.1038/srep28922⟩
Journal articles hal-01356073v1
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The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies

Marcel Knossow , Valérie Campanacci , Liza Ammar-Khodja , Benoît Gigant
iScience, 2020, 23 (9), pp.101511. ⟨10.1016/j.isci.2020.101511⟩
Journal articles hal-02944252v1

GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation

Rie Ayukawa , Seigo Iwata , Hiroshi Imai , Shinji Kamimura , Masahito Hayashi et al.
Journal of Cell Biology, 2021, 220 (e202007033), ⟨10.1083/jcb.202007033⟩
Journal articles hal-03141626v1

Studying Drug-Tubulin Interactions by X-Ray Crystallography

Audrey Dorleans , Marcel Knossow , Benoît Gigant
Microtubule Protocols, pp.235-243, 2007
Book sections hal-02109642v1