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Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities
Damijan Knez
,
Nicolas Coquelle
,
Anja Pišlar
,
Simon Žakelj
,
Marko Jukič
et al.
Journal articles
hal-01924686v1
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Relation between dynamics, activity and thermal stability within the cholinesterase family
Marie Trovaslet
,
Marcus Trapp
,
Martin Weik
,
Florian Nachon
,
Patrick Masson
et al.
Journal articles
hal-01664592v1
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First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
Guillaume Mercey
,
Tristan Verdelet
,
Géraldine Saint-André
,
Emilie Gillon
,
Alain Wagner
et al.
Journal articles
hal-00991912v1
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Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.
Julien Renou
,
Guillaume Mercey
,
Tristan Verdelet
,
Emilia Păunescu
,
Emilie Gillon
et al.
Journal articles
hal-00996535v1
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The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity
Urban Košak
,
Boris Brus
,
Damijan Knez
,
Simon Žakelj
,
Jurij Trontelj
et al.
Journal articles
hal-01991973v1
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N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Urban Košak
,
Damijan Knez
,
Nicolas Coquelle
,
Boris Brus
,
Anja Pišlar
et al.
Journal articles
hal-01465675v1
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Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.
Cyril Ronco
,
Eugénie Carletti
,
Jacques-Philippe Colletier
,
Martin Weik
,
Florian Nachon
et al.
Journal articles
istex
hal-00996475v1
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Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase
Maria Kliachyna
,
Gianluca Santoni
,
Valentin Nussbaum
,
Julien Renou
,
Benoît Sanson
et al.
Journal articles
hal-01131268v1
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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
Elisabet Viayna
,
Nicolas Coquelle
,
Monika Cieslikiewicz-Bouet
,
Pedro Cisternas
,
Carolina Oliva
et al.
Journal articles
hal-03094189v1
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Respiratory failure triggered by cholinesterase inhibitors may involve activation of a reflex sensory pathway by acetylcholine spillover
Aurélie Nervo
,
André-Guilhem Calas
,
Florian Nachon
,
Eric Krejci
Journal articles
hal-02323726v1
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Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents
Guillaume Mercey
,
Tristan Verdelet
,
Julien Renou
,
Maria Kliachyna
,
Rachid Baati
et al.
Journal articles
hal-01015972v1
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Apport des structures cristallographiques à la compréhension du mécanisme d'inhibition des cholinestérases par les neurotoxiques organophosphorés
Florian Nachon
Biologie structurale [q-bio.BM]. Université Joseph Fourier, 2014
Habilitation à diriger des recherches
tel-01287758v1
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Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration
Tamara Zorbaz
,
Anissa Braïki
,
Nikola Marakovic
,
Julien Renou
,
Eugenio de La Mora
et al.
Journal articles
hal-02024542v1
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Dynamics of human acetylcholinesterase bound to non-covalent and covalent inhibitors shedding light on changes to the water network structure
Judith Peters
,
Nicolas Martinez
,
Marie Trovaslet
,
Kévin Scannapieco
,
Michael Marek Koza
et al.
Physical Chemistry Chemical Physics, 2016, 18 (18), pp.12992-13001
Journal articles
hal-02002944v1
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Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors
Cyril Ronco
,
Geoffroy Sorin
,
Florian Nachon
,
Richard Foucault
,
Ludovic Jean
et al.
Journal articles
hal-03808202v1
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Development of an in-vivo active reversible butyrylcholinesterase inhibitor.
Urban Košak
,
Boris Brus
,
Damijan Knez
,
Roman Šink
,
Simon Žakelj
et al.
Journal articles
hal-01465678v1
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Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
Florian Nachon
,
Eugénie Carletti
,
Cyril Ronco
,
Marie Trovaslet
,
Yvain Nicolet
et al.
Journal articles
hal-00996550v1
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Synthesis and in vitro and in vivo evaluations of New Uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents
Anissa Braïki
,
Julien Renou
,
Romain Mougeot
,
Florian Nachon
,
José Dias
et al.
Medical Chemical Defense Conference (MCDC, 17, 2019), Mar 2019, Munich, Germany
Conference poster
hal-02543452v1
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Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.
M Trapp
,
M Tehei
,
Marie Trovaslet
,
Florian Nachon
,
Nicolas Martinez
et al.
Journal of the Royal Society Interface, 2014, 11 (97), pp.20140372
Journal articles
hal-01131840v1
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Composition and methods for the purification and production of butyrylcholinesterase.
O. Lockridge,
,
M.A. Larson,
,
S.H. Schopfer,
,
S.H. Hinrichs,
,
Florian Nachon
et al.
France, Patent n° : PCT/US14/66373. 2014
Patents
hal-01150306v1
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Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterase
Julien Renou
,
Melanie Loiodice
,
Melanie Arboleas
,
Rachid Baati
,
Ludovic Jean
et al.
Journal articles
hal-01150284v1
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A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
Ophélie da Silva
,
Nicolas Probst
,
Christophe Landry
,
Anne-Sophie Hanak
,
Pierre Warnault
et al.
Journal articles
hal-03706969v1
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Preparation of 7,11-Methanocycloocta[b]quinoline derivative as highly functionalizable acetylcholinesterase inhibitors for treating neurological diseases
Cyril Ronco
,
Pierre-Yves Renard
,
Ludovic Jean
,
Florian Nachon
,
Anthony Romieu
et al.
France, Patent n° : WO 2011124712 A1. 2011
Patents
hal-01150301v1
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An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice
André-Guilhem Calas
,
José Dias
,
Catherine Rousseau
,
Mélanie Arboléas
,
Mélanie Touvrey-Loiodice
et al.
Journal articles
hal-02046266v1
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New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors.
Cyril Ronco
,
Richard Foucault
,
Emilie Gillon
,
Pierre Bohn
,
Florian Nachon
et al.
Journal articles
istex
hal-00991920v1
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Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime
André-Guilhem Calas
,
Anne-Sophie Hanak
,
Nina Jaffré
,
Aurélie Nervo
,
José Dias
et al.
Journal articles
hal-03127255v1
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On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach
Thomas Driant
,
Florian Nachon
,
Cyril Ollivier
,
Pierre-Yves Renard
,
Etienne Derat
et al.
Journal articles
hal-01644385v1
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Reaction site-driven regioselective synthesis of AChE inhibitors
Emilia Oueis
,
Gianluca Santoni
,
Cyril Ronco
,
Olga A. Syzgantseva
,
Vincent Tognetti
et al.
Journal articles
hal-02335933v1
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Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase
Julien Renou
,
José Dias
,
Guillaume Mercey
,
Tristan Verdelet
,
Catherine Rousseau
et al.
Journal articles
hal-02046237v1
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Uncharged reactivators of cholinesterases inhibited by organophosphorus nerve agents.
Nicolas Probst
,
Anissa Braïki
,
Pierre Warnault
,
Julien Renou
,
Catherine Gomez
et al.
International Meeting on Cholinesterases (13, 2018) and International Conference on Paraoxonases (7, 2018)), Sep 2018, Hradec Králové, Czech Republic
Conference poster
hal-02543467v1
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