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authFullName_s : Frédéric Simonin
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Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors

Jolien de Neve , Thomas M. A. Barlow , Dirk Tourwé , Frédéric Bihel , Frédéric Simonin et al.
RSC Medicinal Chemistry, 2021, 12 (6), pp.828-870. ⟨10.1039/D1MD00041A⟩
Journal articles hal-03442028v1
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Characterization of anti-GASP motif antibodies that inhibit the interaction between GPRASP1 and G protein-coupled receptors

Gabrielle Zeder Lutz , Olivier Bornert , Rosine Fellmann-Clauss , Adeline Knittel-Obrecht , Thibaud Tranchant et al.
Analytical Biochemistry, 2023, 665, pp.115062. ⟨10.1016/j.ab.2023.115062⟩
Journal articles hal-04029386v1
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Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors

Jolien de Neve , Thomas M A Barlow , Dirk Tourwé , Frédéric Bihel , Frédéric Simonin et al.
RSC Medicinal Chemistry, 2021
Journal articles hal-03435229v1
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Behavioral Characterization, Potential Clinical Relevance and Mechanisms of Latent Pain Sensitization

Manon Gerum , Frédéric Simonin
Pharmacology & Therapeutics, 2022, 233, pp.108032
Journal articles hal-03435269v1

RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.

Frédéric Simonin , Martine Schmitt , Jean-Paul Laulin , Emilie Laboureyras , Jack H Jhamandas et al.
Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (2), pp.466-71. ⟨10.1073/pnas.0502090103⟩
Journal articles hal-00188146v1
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Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide

Laurie-Anne Roeckel , Valérie Utard , David Reiss , Jinane Mouheiche , Hervé Maurin et al.
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-11120-4⟩
Journal articles hal-03448002v1

A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects

Armand Drieu La Rochelle , Karel Guillemyn , Maria Dumitrascuta , Charlotte Martin , Valérie Utard et al.
PAIN, 2018, 159 (9), pp.1705-1718. ⟨10.1097/j.pain.0000000000001262⟩
Journal articles hal-02368742v1

Development of Dipeptidic hGPR54 Agonists

Christelle Doebelin , Isabelle I. Bertin , Séverine Schneider , Martine Schmitt , Jean-Jacques Bourguignon et al.
ChemMedChem, 2016, 11 (19), pp.2147-2154. ⟨10.1002/cmdc.201600331⟩
Journal articles istex hal-02368845v1

RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions

Raphaelle Quillet , Safia Ayachi , Frédéric Bihel , Khadija Elhabazi , Brigitte Ilien et al.
Alimentary Pharmacology & Therapeutics (Suppl), 2016, 160, pp.84-132. ⟨10.1016/j.pharmthera.2016.02.005⟩
Journal articles hal-02368835v1
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Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice

Julien Boeuf , José Manuel Trigo , Pierre-Henri Moreau , Lucas Lecourtier , Elise Vogel et al.
European Journal of Neuroscience, 2009, 30 (5), pp.860-868. ⟨10.1111/j.1460-9568.2009.06865.x⟩
Journal articles hal-03037839v1
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Recombinant Human Melatonin Receptor MT1 Isolated in Mixed Detergents Shows Pharmacology Similar to That in Mammalian Cell Membranes

Christel Logez , Sylvie Berger , Céline Legros , Jean-Louis Baneres , William Cohen et al.
PLoS ONE, 2014, 9 (6), pp.e100616. ⟨10.1371/journal.pone.0100616⟩
Journal articles hal-03573074v1

Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia

Hassan Hammoud , Khadija Elhabazi , Isabelle Bertin , Valeŕie Utard , Emilie Laboureyras et al.
ACS Chemical Neuroscience, 2018, 9 (11), pp.2599-2609. ⟨10.1021/acschemneuro.8b00099⟩
Journal articles hal-02323065v1
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RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents

Khadija Elhabazi , Jean-Paul Humbert , Isabelle Bertin , Raphaelle Quillet , Valérie Utard et al.
Neuropsychopharmacology, 2017, 118, pp.188-198. ⟨10.1016/j.neuropharm.2017.03.012⟩
Journal articles hal-01603852v1
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Identification of an N -acylated- D Arg-Leu-NH 2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia

Raphaëlle Quillet , Séverine Schneider , Valérie Utard , Armand Drieu La Rochelle , Khadija Elhabazi et al.
Journal of Medicinal Chemistry, 2021, 64 (11), pp.7555-7564. ⟨10.1021/acs.jmedchem.1c00256⟩
Journal articles hal-03363456v1
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Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization

Manon Gerum , Frédéric Simonin
Pharmacology and Therapeutics, 2021, 233, pp.108032. ⟨10.1016/j.pharmthera.2021.108032⟩
Journal articles hal-03698407v1

Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal

Frédéric Simonin , Olga Valverde , Claire Smadja , Susan Slowe , Ian Kitchen et al.
EMBO Journal, 1998, 17 (4), pp.886-897. ⟨10.1093/emboj/17.4.886⟩
Journal articles hal-04017114v1