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New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment
Herve Poras
,
Elisabeth Bonnard
,
Emilie Dange
,
Marie-Claude Fournie-Zaluski
,
Bernard P. Roques
et al.
Journal articles
hal-03292704v1
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Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain
Elisabeth Bonnard
,
Herve Poras
,
Marie-Claude Fournie-Zaluski
,
Bernard P. Roques
Journal articles
hal-03292701v1
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Side-Chain-Modified Sulfonic Analogues of Aspartic and Glutamic Acids: Synthesis, Protection, and Incorporation into Peptides
Laurent Bischoff
,
Christelle David
,
Bernard Pierre Roques
,
Marie-Claude Fournie-Zaluski
Journal articles
istex
hal-02385506v1
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Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101
Florence Noble
,
Pascale Coric
,
Marie-Claude Fournie-Zaluski
,
Bernard P. Roques
Journal articles
istex
hal-02461500v1
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Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101
Florence Noble
,
Pascale Coric
,
Serge Turcaud
,
Marie-Claude Fournie-Zaluski
,
Bernard P. Roques
et al.
Journal articles
istex
hal-02461489v1
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Straightforward and Diastereoselective Synthesis of Tetrafunctionalized Thiol Synthons for the Design of Metallopeptidase Inhibitors
Christelle David
,
Laurent Bischoff
,
Bernard P. Roques
,
Marie-Claude Fournie-Zaluski
Journal articles
istex
hal-02385509v1
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Synthesis of [3(R)-amino-2(S)-sulfhydryl-5-sulfonate]-pentanoyl-(S)-3-[125I]-iodotyrosyl-(S)-aspartic acid: a radiolabelled inhibitor of aminopeptidase A
Christelle David-Basei
,
Laurent Bischoff
,
Marie-Claude Fournie-Zaluski
,
Bernard P. Roques
Journal of Labelled Compounds and Radiopharmaceuticals, 2001, 44 (1), pp.89-98. ⟨10.1002/jlcr.445⟩
Journal articles
istex
hal-02385512v1
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β-Amino-thiols Inhibit the Zinc Metallopeptidase Activity of Tetanus Toxin Light Chain
Loïc M Martin
,
Fabrice Cornille
,
Pascale Coric
,
Bernard P. Roques
,
Marie-Claude Fournie-Zaluski
et al.
Journal articles
istex
hal-02461413v1
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Differences in transition state stabilization between thermolysin (EC 3.4.24.27) and neprilysin (EC 3.4.24.11).
Cynthia Marie-Claire
,
Emmanuel Ruffet
,
Gilles Tiraboschi
,
Marie-Claude Fournie-Zaluski
FEBS Letters, 1998, 438 (3), pp.215-9
Journal articles
inserm-00145191v1
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2,4-Dinitrophenyl 4-Methoxybenzyl Disulfide: A New Efficient Reagent for the Electrophilic Sulfenylation of β-Amino Ester Enolates
Laurent Bischoff
,
Christelle David
,
Loïc M Martin
,
Hervé Meudal
,
Bernard-Pierre Roques
et al.
Journal articles
istex
hal-02122111v1
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Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides
Christelle David
,
Laurent Bischoff
,
Hervé Meudal
,
Catherine Llorens-Cortes
,
Bernard Pierre Roques
et al.
Journal articles
istex
hal-02122127v1
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Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain
Elisabeth Bonnard
,
Herve Poras
,
Xavier Nadal
,
Rafael Maldonado
,
Marie-Claude Fournie-Zaluski
et al.
Journal articles
hal-03292708v1
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Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme
Christelle David
,
Laurent Bischoff
,
Hervé Meudal
,
Aurélie Mothé
,
Nadia de Mota
et al.
Journal articles
istex
hal-02122148v1
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Synthesis of 2(S)-benzyl-3-[hydroxy(1?(R)-amino ethyl)phosphinyl]propanoyl-L-3-[125I]-iodotyrosine: a radiolabelled inhibitor of aminopeptidase N
Huixiong Chen
,
Laurent Bischoff
,
Marie-Claude Fournie-Zaluski
,
Bernard P. Roques
Journal articles
istex
hal-02385510v1
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Substituted alpha-mercaptoketones, new types of specific neprilysin inhibitors
Herve Poras
,
Remi Patouret
,
Simon Leiris
,
Tanja Ouimet
,
Marie-Claude Fournie-Zaluski
et al.
Journal articles
hal-03292700v1
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Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
Sara Gonzalez-Rodriguez
,
Herve Poras
,
Luis Menendez
,
Ana Lastra
,
Tanja Ouimet
et al.
Journal articles
hal-03292702v1
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Optimal Recognition of Neutral Endopeptidase and Angiotensin-Converting Enzyme Active Sites by Mercaptoacyldipeptides as a Means To Design Potent Dual Inhibitors
Pascale Coric
,
Serge Turcaud
,
Hervé Meudal
,
Bernard Pierre Roques
,
Marie-Claude Fournie-Zaluski
et al.
Journal articles
istex
hal-02122055v1
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Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Nicolas Inguimbert
,
Pascale Coric
,
Hervé Poras
,
Hervé Meudal
,
Franck Teffot
et al.
Journal of Medicinal Chemistry, 2002, 45 (7), pp.1477-86
Journal articles
hal-02122182v1
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Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme
Christelle David
,
Laurent Bischoff
,
Hervé Meudal
,
Aurélie Mothé
,
Nadia de Mota
et al.
Journal articles
istex
hal-02385508v1
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Development of Potent Inhibitors of Botulinum Neurotoxin Type B
Christine Anne
,
Serge Turcaud
,
Jean Quancard
,
Franck Teffo
,
Hervé Meudal
et al.
Journal articles
istex
hal-02122278v1
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Design of Orally Active Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme with Long Duration of Action
Marie-Claude Fournie-Zaluski
,
Pascale Coric
,
Vincent Théry
,
Walter D Gonzalez
,
Hervé Meudal
et al.
Journal articles
istex
hal-02122108v1
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New Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme: Rational Design, Bioavailability, and Pharmacological Responses in Experimental Hypertension
Marie-Claude Fournie-Zaluski
,
Pascale Coric
,
Serge Turcaud
,
Nathalie Rousselet
,
Walter D Gonzalez
et al.
Journal articles
istex
hal-02461485v1
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Synthesis and separation of tritiated inhibitors of aminopeptidase A and their prodrugs
Nicolas Inguimbert
,
Pascale Coric
,
Hélène Dhotel
,
Catherine Llorens-Cortès
,
Marie-Claude Fournie-Zaluski
et al.
Journal of Labelled Compounds and Radiopharmaceuticals, 2004, 47 (13), pp.997-1005. ⟨10.1002/jlcr.888⟩
Journal articles
istex
hal-02461363v1
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Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route
Herve Poras
,
Elisabeth Bonnard
,
Marie-Claude Fournie-Zaluski
,
Bernard P. Roques
Journal articles
hal-03292709v1
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Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120
Florence Noble
,
Claire Smadja
,
Olga Valverde
,
Rafael Maldonado
,
Pascale Coric
et al.
Journal articles
istex
hal-02461424v1
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Differential Inhibition of Aminopeptidase A and Aminopeptidase N by New .beta.-Amino Thiols
Eric Chauvel
,
Catherine Llorens-Cortès
,
Pascale Coric
,
Sherwin Wilk
,
Bernard P. Roques
et al.
Journal articles
istex
hal-02461510v1
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Investigation of the Active Site of Aminopeptidase A Using a Series of New Thiol-Containing Inhibitors
Eric Chauvel
,
Pascale Coric
,
Catherine Llorens-Cortès
,
Sherwin Wilk
,
Bernard P. Roques
et al.
Journal articles
istex
hal-02461480v1
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Exploration of the S'1 subsite of neprilysin: a joined molecular modeling and site-directed mutagenesis study.
Cynthia Marie-Claire
,
Gilles Tiraboschi
,
Emmanuel Ruffet
,
Nicolas Inguimbert
,
Marie-Claude Fournie-Zaluski
et al.
Proteins - Structure, Function and Bioinformatics, 2000, 39 (4), pp.365-71
Journal articles
inserm-00171018v1
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