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authFullName_s : Marie-Claude Fournie-Zaluski

New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment

Herve Poras , Elisabeth Bonnard , Emilie Dange , Marie-Claude Fournie-Zaluski , Bernard P. Roques et al.
Journal of Medicinal Chemistry, 2014, 57 (13), pp.5748-5763. ⟨10.1021/jm500602h⟩
Journal articles hal-03292704v1

Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain

Elisabeth Bonnard , Herve Poras , Marie-Claude Fournie-Zaluski , Bernard P. Roques
European Journal of Pharmacology, 2016, 788, pp.176-182. ⟨10.1016/j.ejphar.2016.05.041⟩
Journal articles hal-03292701v1

Side-Chain-Modified Sulfonic Analogues of Aspartic and Glutamic Acids: Synthesis, Protection, and Incorporation into Peptides

Laurent Bischoff , Christelle David , Bernard Pierre Roques , Marie-Claude Fournie-Zaluski
Journal of Organic Chemistry, 1999, 64 (4), pp.1420-1423. ⟨10.1021/jo9812680⟩
Journal articles istex hal-02385506v1

Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101

Florence Noble , Pascale Coric , Marie-Claude Fournie-Zaluski , Bernard P. Roques
European Journal of Pharmacology, 1992, 223 (1), pp.91-96. ⟨10.1016/0014-2999(92)90822-L⟩
Journal articles istex hal-02461500v1

Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101

Florence Noble , Pascale Coric , Serge Turcaud , Marie-Claude Fournie-Zaluski , Bernard P. Roques et al.
European Journal of Pharmacology, 1994, 253 (3), pp.283-287. ⟨10.1016/0014-2999(94)90203-8⟩
Journal articles istex hal-02461489v1

Straightforward and Diastereoselective Synthesis of Tetrafunctionalized Thiol Synthons for the Design of Metallopeptidase Inhibitors

Christelle David , Laurent Bischoff , Bernard P. Roques , Marie-Claude Fournie-Zaluski
Tetrahedron, 2000, 56 (2), pp.209-215. ⟨10.1016/S0040-4020(99)00922-9⟩
Journal articles istex hal-02385509v1

Synthesis of [3(R)-amino-2(S)-sulfhydryl-5-sulfonate]-pentanoyl-(S)-3-[125I]-iodotyrosyl-(S)-aspartic acid: a radiolabelled inhibitor of aminopeptidase A

Christelle David-Basei , Laurent Bischoff , Marie-Claude Fournie-Zaluski , Bernard P. Roques
Journal of Labelled Compounds and Radiopharmaceuticals, 2001, 44 (1), pp.89-98. ⟨10.1002/jlcr.445⟩
Journal articles istex hal-02385512v1

β-Amino-thiols Inhibit the Zinc Metallopeptidase Activity of Tetanus Toxin Light Chain

Loïc M Martin , Fabrice Cornille , Pascale Coric , Bernard P. Roques , Marie-Claude Fournie-Zaluski et al.
Journal of Medicinal Chemistry, 1998, 41 (18), pp.3450-3460. ⟨10.1021/jm981015z⟩
Journal articles istex hal-02461413v1
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Differences in transition state stabilization between thermolysin (EC 3.4.24.27) and neprilysin (EC 3.4.24.11).

Cynthia Marie-Claire , Emmanuel Ruffet , Gilles Tiraboschi , Marie-Claude Fournie-Zaluski
FEBS Letters, 1998, 438 (3), pp.215-9
Journal articles inserm-00145191v1

2,4-Dinitrophenyl 4-Methoxybenzyl Disulfide: A New Efficient Reagent for the Electrophilic Sulfenylation of β-Amino Ester Enolates

Laurent Bischoff , Christelle David , Loïc M Martin , Hervé Meudal , Bernard-Pierre Roques et al.
Journal of Organic Chemistry, 1997, 62 (14), pp.4848-4850. ⟨10.1021/jo9623853⟩
Journal articles istex hal-02122111v1

Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides

Christelle David , Laurent Bischoff , Hervé Meudal , Catherine Llorens-Cortes , Bernard Pierre Roques et al.
Letters in Peptide Science, 1997, 4 (4/6), pp.411-414. ⟨10.1023/A:1008894115205⟩
Journal articles istex hal-02122127v1
Image document

Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain

Elisabeth Bonnard , Herve Poras , Xavier Nadal , Rafael Maldonado , Marie-Claude Fournie-Zaluski et al.
Pharmacology Research & Perspectives, 2015, 3 (2), ⟨10.1002/prp2.116⟩
Journal articles hal-03292708v1

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Christelle David , Laurent Bischoff , Hervé Meudal , Aurélie Mothé , Nadia de Mota et al.
Journal of Medicinal Chemistry, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩
Journal articles istex hal-02122148v1

Synthesis of 2(S)-benzyl-3-[hydroxy(1?(R)-amino ethyl)phosphinyl]propanoyl-L-3-[125I]-iodotyrosine: a radiolabelled inhibitor of aminopeptidase N

Huixiong Chen , Laurent Bischoff , Marie-Claude Fournie-Zaluski , Bernard P. Roques
Journal of Labelled Compounds and Radiopharmaceuticals, 2000, 43 (2), pp.103-111. ⟨10.1002/(SICI)1099-1344(200002)43:2<103::AID-JLCR294>3.0.CO;2-I⟩
Journal articles istex hal-02385510v1

Substituted alpha-mercaptoketones, new types of specific neprilysin inhibitors

Herve Poras , Remi Patouret , Simon Leiris , Tanja Ouimet , Marie-Claude Fournie-Zaluski et al.
Bioorganic & Medicinal Chemistry Letters, 2017, 27 (16), pp.3883-3890. ⟨10.1016/j.bmcl.2017.06.050⟩
Journal articles hal-03292700v1

Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain

Sara Gonzalez-Rodriguez , Herve Poras , Luis Menendez , Ana Lastra , Tanja Ouimet et al.
Scandinavian Journal of Pain, 2017, 14, pp.25-38. ⟨10.1016/j.sjpain.2016.09.011⟩
Journal articles hal-03292702v1

Optimal Recognition of Neutral Endopeptidase and Angiotensin-Converting Enzyme Active Sites by Mercaptoacyldipeptides as a Means To Design Potent Dual Inhibitors

Pascale Coric , Serge Turcaud , Hervé Meudal , Bernard Pierre Roques , Marie-Claude Fournie-Zaluski et al.
Journal of Medicinal Chemistry, 1996, 39 (6), pp.1210-1219. ⟨10.1021/jm950590p⟩
Journal articles istex hal-02122055v1

Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).

Nicolas Inguimbert , Pascale Coric , Hervé Poras , Hervé Meudal , Franck Teffot et al.
Journal of Medicinal Chemistry, 2002, 45 (7), pp.1477-86
Journal articles hal-02122182v1

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Christelle David , Laurent Bischoff , Hervé Meudal , Aurélie Mothé , Nadia de Mota et al.
Journal of Medicinal Chemistry, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩
Journal articles istex hal-02385508v1

Development of Potent Inhibitors of Botulinum Neurotoxin Type B

Christine Anne , Serge Turcaud , Jean Quancard , Franck Teffo , Hervé Meudal et al.
Journal of Medicinal Chemistry, 2003, 46 (22), pp.4648-4656. ⟨10.1021/jm0300680⟩
Journal articles istex hal-02122278v1

Design of Orally Active Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme with Long Duration of Action

Marie-Claude Fournie-Zaluski , Pascale Coric , Vincent Théry , Walter D Gonzalez , Hervé Meudal et al.
Journal of Medicinal Chemistry, 1996, 39 (13), pp.2594-2608. ⟨10.1021/jm950783c⟩
Journal articles istex hal-02122108v1

New Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme: Rational Design, Bioavailability, and Pharmacological Responses in Experimental Hypertension

Marie-Claude Fournie-Zaluski , Pascale Coric , Serge Turcaud , Nathalie Rousselet , Walter D Gonzalez et al.
Journal of Medicinal Chemistry, 1994, 37 (8), pp.1070-1083. ⟨10.1021/jm00034a005⟩
Journal articles istex hal-02461485v1

Synthesis and separation of tritiated inhibitors of aminopeptidase A and their prodrugs

Nicolas Inguimbert , Pascale Coric , Hélène Dhotel , Catherine Llorens-Cortès , Marie-Claude Fournie-Zaluski et al.
Journal of Labelled Compounds and Radiopharmaceuticals, 2004, 47 (13), pp.997-1005. ⟨10.1002/jlcr.888⟩
Journal articles istex hal-02461363v1

Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route

Herve Poras , Elisabeth Bonnard , Marie-Claude Fournie-Zaluski , Bernard P. Roques
European Journal of Medicinal Chemistry, 2015, 102, pp.58-67. ⟨10.1016/j.ejmech.2015.07.027⟩
Journal articles hal-03292709v1

Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120

Florence Noble , Claire Smadja , Olga Valverde , Rafael Maldonado , Pascale Coric et al.
PAIN, 1997, 73 (3), pp.383-391. ⟨10.1016/S0304-3959(97)00125-5⟩
Journal articles istex hal-02461424v1

Differential Inhibition of Aminopeptidase A and Aminopeptidase N by New .beta.-Amino Thiols

Eric Chauvel , Catherine Llorens-Cortès , Pascale Coric , Sherwin Wilk , Bernard P. Roques et al.
Journal of Medicinal Chemistry, 1994, 37 (18), pp.2950-2957. ⟨10.1021/jm00044a016⟩
Journal articles istex hal-02461510v1

Investigation of the Active Site of Aminopeptidase A Using a Series of New Thiol-Containing Inhibitors

Eric Chauvel , Pascale Coric , Catherine Llorens-Cortès , Sherwin Wilk , Bernard P. Roques et al.
Journal of Medicinal Chemistry, 1994, 37 (9), pp.1339-1346. ⟨10.1021/jm00035a014⟩
Journal articles istex hal-02461480v1
Image document

Exploration of the S'1 subsite of neprilysin: a joined molecular modeling and site-directed mutagenesis study.

Cynthia Marie-Claire , Gilles Tiraboschi , Emmanuel Ruffet , Nicolas Inguimbert , Marie-Claude Fournie-Zaluski et al.
Proteins - Structure, Function and Bioinformatics, 2000, 39 (4), pp.365-71
Journal articles inserm-00171018v1