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authFullName_s : Nadia de Mota

Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei.

Nadia de Mota , Xavier Iturrioz , Cedric Claperon , Laurence Bodineau , Celine Fassot et al.
Journal of Neurochemistry, 2008, 106 (1), pp.416-28. ⟨10.1111/j.1471-4159.2008.05402.x⟩
Journal articles inserm-00422677v1

Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist

Xavier Iturrioz , Rodrigo Alvear-Perez , Nadia de Mota , Christel Franchet , Fabrice Guillier et al.
FASEB Journal, 2010, 24 (5), pp.1506-1517. ⟨10.1096/fj.09-140715⟩
Journal articles hal-00547967v1

Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli.

Michel Azizi , Xavier Iturrioz , Anne Blanchard , Séverine Peyrard , Nadia de Mota et al.
Journal of the American Society of Nephrology, 2008, 19 (5), pp.1015-24. ⟨10.1681/ASN.2007070816⟩
Journal articles inserm-00422689v1
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Activating the apelin receptor with LIT01-196, a metabolically stable apelin analog, reverses AVP-induced antidiuresis and hyponatremia

Adrien Flahault , Pierre-Emmanuel Girault-Sotias , Mathilde Keck , Rodrigo Alvear-Perez , Nadia de Mota et al.
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-020-20560-y⟩
Journal articles hal-03285794v1

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Christelle David , Laurent Bischoff , Hervé Meudal , Aurélie Mothé , Nadia de Mota et al.
Journal of Medicinal Chemistry, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩
Journal articles istex hal-02122148v1
Image document

Identification and Characterization of E339-3D6, the First Nonpeptidic Apelin Receptor Agonist XAVIER ITURRIOZ

Xavier Itturioz , Rodrigo Alvear-Perez , Nadia de Mota , Christel Franchet , Fabrice Guillier et al.
FASEB Journal, 2010, ⟨10.1096/fj.09-140715⟩
Journal articles hal-02196074v1

A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension

Michel Azizi , Pierre-Yves Courand , Thierry Denolle , Pascal Delsart , Valentina Zhygalina et al.
Journal of Hypertension, 2019, 37 (8), pp.1722-1728. ⟨10.1097/HJH.0000000000002092⟩
Journal articles hal-03149099v1
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QGC606: A Best-in-Class Orally Active Centrally Acting Aminopeptidase A Inhibitor Prodrug for Treating Heart Failure Following Myocardial Infarction

Solène E Boitard , Mathilde Keck , Robin Deloux , Pierre-Emmanuel Girault-Sotias , Yannick Marc et al.
Canadian Journal of Cardiology, 2022, 38 (6), pp.815-827. ⟨10.1016/j.cjca.2022.01.019⟩
Journal articles hal-03834295v1
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LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Adrien Flahault , Mathilde Keck , Pierre-Emmanuel Girault-Sotias , Lucie Esteoulle , Nadia de Mota et al.
Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.715095⟩
Journal articles hal-03322968v1

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Christelle David , Laurent Bischoff , Hervé Meudal , Aurélie Mothé , Nadia de Mota et al.
Journal of Medicinal Chemistry, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩
Journal articles istex hal-02385508v1

Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli

Michel Azizi , Xavier Iturrioz , Anne Blanchard , Séverine Peyrard , Nadia de Mota et al.
Journal of the American Society of Nephrology, 2008, 19 (5), pp.1015-1024. ⟨10.1681/ASN.2007070816⟩
Journal articles hal-03631046v1

Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug

Fabrice Balavoine , Michel Azizi , Damien Bergerot , Nadia de Mota , Remi Patouret et al.
Clinical Pharmacokinetics, 2014, 53 (4), pp.385-395. ⟨10.1007/s40262-013-0125-y⟩
Journal articles hal-03292696v1

A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia

Adrien Flahault , Pierre-Emmanuel Girault-Sotias , Mathilde Keck , Rodrigo Alvear-Perez , Nadia de Mota et al.
Nature Communications, 2021, 12 (1), pp.305. ⟨10.1038/s41467-020-20560-y⟩
Journal articles hal-03630786v1

Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release

Annabelle Reaux-Le Goazigo , Laurence Bodineau , Nadia de Mota , Lydie Jeandel , Nicolas Chartrel et al.
AJP - Endocrinology and Metabolism, 2011, 301 (5), pp.E955-E966. ⟨10.1152/ajpendo.00090.2011⟩
Journal articles hal-03990052v1

Development of original metabolically stable apelin‐17 analogs with diuretic and cardiovascular effects

Romain Gerbier , Rodrigo Alvear‐perez , Jean‐francois Margathe , Adrien Flahault , Pierre Couvineau et al.
FASEB Journal, 2016, 31 (2), pp.687-700. ⟨10.1096/fj.201600784R⟩
Journal articles hal-03631032v1

Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei

Nadia de Mota , Xavier Iturrioz , Cedric Claperon , Laurence Bodineau , Celine Fassot et al.
Journal of Neurochemistry, 2008, 106 (1), pp.416-428. ⟨10.1111/j.1471-4159.2008.05402.x⟩
Journal articles hal-03631044v1