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authFullName_s : Qing Nian
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Loss-of-Function Mutation in PTPN2 Causes Aberrant Activation of JAK Signaling Via STAT and Very Early Onset Intestinal Inflammation

Marianna Parlato , Qing Nian , Fabienne Charbit-Henrion , Frank Ruemmele , Fernando Rodrigues-Lima et al.
Gastroenterology, 2020, 159 (5), pp.1968-1971.e4. ⟨10.1053/j.gastro.2020.07.040⟩
Journal articles hal-03066001v1
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Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling

Romain Duval , Linh-Chi Bui , Cécile Mathieu , Qing Nian , Jérémy Berthelet et al.
Journal of Biological Chemistry, 2019, 294 (33), pp.12483-12494. ⟨10.1074/jbc.RA119.008666⟩
Journal articles hal-02358303v1

Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 ( Cys216Gly ) that causes very early onset autoimmune enteropathy

Qing Nian , Jérémy Berthelet , Marianna Parlato , Ariel E Mechaly , Rongxing Liu et al.
Protein Science, 2021, ⟨10.1002/pro.4246⟩
Journal articles pasteur-03524511v1
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T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide

Qing Nian , Jeremy Berthelet , Wenchao Zhang , Linh-Chi Bui , Rongxing Liu et al.
Molecular Pharmacology, 2019, 96 (2), pp.297-306. ⟨10.1124/mol.119.116319⟩
Journal articles hal-03201556v1