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Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose
Béatrice Vallée
,
Karen Plé
,
A. Cosson
,
M. Doudeau
,
F. Godin
et al.
Journée Fédération CBM-ICOA, Jan 2018, Orléans, France
Conference papers
hal-02928530v1
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First Palladium-Catalyzed Direct Regioselective C-5 (Het)Arylation of Mono- or Disubstituted Thiazolo[3,2- b ][1,2,4]triazoles
Mikaël Le Meur
,
Stéphane Bourg
,
Stéphane Massip
,
Mathieu Marchivie
,
Christian Jarry
et al.
Journal articles
istex
hal-02904759v1
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LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo
Rayan Berabez
,
Sylvain Routier
,
Hélène Bénédetti
,
Karen Plé
,
Béatrice Vallée
et al.
Journal articles
hal-03721458v1
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Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles
Kossi Efouako Soklou
,
Hamid Marzag
,
Jean-Philippe Bouillon
,
Mathieu Marchivie
,
Sylvain Routier
et al.
Journal articles
hal-02916186v1
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Development of a bioactive fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action
Justine Corret
,
Sokaina Hammoud
,
Frédéric Buron
,
Pierre Daligaux
,
Christophe Chesné
et al.
FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia
Conference poster
hal-03679980v1
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Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines
Vanessa Desplat
,
Marian Vincenzi
,
Romain Lucas
,
Stéphane Moreau
,
Solène Savrimoutou
et al.
Journal articles
hal-01307573v1
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Multi Target directed ligands for the treatment of Alzheimer’s disease
Sovy Chao
,
Killian Oukoloff
,
Monika Bouet
,
Diego Muñoz Torrero
,
Jacques-Philippe Colletier
et al.
Rencontres internationales de chimie thérapeutique (RICT, 52, 2016), Jul 2016, Caen, France
Conference poster
hal-02544849v1
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Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness
Pierre-Francois Cartron
,
Mathilde Cheray
,
Arulraj Nadaradjane
,
Pascal Bonnet
,
Sylvain Routier
et al.
Journal articles
inserm-02478615v1
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LIM kinases: new therapeutic targets to treat Neurofibromatosis type I
Béatrice Vallée
,
Michel Doudeau
,
Fabienne Godin
,
Anthony Champiré
,
Karen Plé
et al.
The 7th EMBO meeting, Sep 2016, Mannheim, Germany.
Conference poster
hal-02453490v1
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Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo
Shotaro Uehara
,
Makiko Shimizu
,
Karen Plé
,
Sylvain Routier
,
Nao Yoneda
et al.
Journal articles
hal-03721472v1
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Design of $\alpha$7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [$^{18}$F] quinuclidine derivative
Sylvie Mavel
,
Frédéric Pin
,
Johnny Vercouillie
,
Aziz Ouach
,
Zuhal Gulhan
et al.
Journal articles
hal-01826403v1
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Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors
Frédéric Buron
,
Nuno Rodrigues
,
Thibault Saurat
,
Marie-Aude Hiebel
,
Stéphane Bourg
et al.
Journal articles
hal-03348966v1
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Synthesis of γ-carboline N-oxide under gold(I)-catalysis and C-1 amino and fluoro γ-carboline
Zak Agnieszka
,
Hamid Marzag
,
Rodrigues Nuno
,
Vercouillie Johnny
,
Sylvie Chalon
et al.
Journal articles
hal-03717446v1
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30th Franco-Belgian conference of pharmacochemistry
Charlotte Bouckaert
,
Eric Goffin
,
Sebastien Dilly
,
Julien Hanson
,
Lionel Pochet
et al.
Journal articles
hal-02141338v1
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Oxidation of CuII to CuIII, Free Radical Production, and DNA Cleavage by Hydroxy-salen−Copper Complexes. Isomeric Effects Studied by ESR and Electrochemistry
Eric Lamour
,
Sylvain Routier
,
Jean-Luc Bernier
,
Jean-Pierre Catteau
,
Christian Bailly
et al.
Journal of the American Chemical Society, 1999, Journal of the American Chemical Society, 121 (9), pp.1862-1869. ⟨10.1021/ja982221z⟩
Journal articles
istex
hal-03420210v1
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Development and preclinical evaluation of [18F]FBVM as a new potent PET tracer for vesicular acetylcholine transporter
Johnny Vercouillie
,
Frédéric Buron
,
Sophie Sérrière
,
Nuno Rodrigues
,
Zuhal Gulhan
et al.
Journal articles
hal-03881143v1
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Design and biological evaluation of substituted 5,7-dihydro-6 H -indolo[2,3- c ]quinolin-6-one as novel selective Haspin inhibitors
Sreenivas Avula
,
Xudan Peng
,
Xingfen Lang
,
Micky Tortorella
,
Béatrice Josselin
et al.
Journal articles
hal-03818922v1
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Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I
Béatrice Vallée
,
A. Cosson
,
M. Doudeau
,
F. Godin
,
A. Champiré
et al.
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Conference poster
hal-02924077v1
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Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.
Sylvain Routier
,
Jean-Yves Mérour
,
Nathalie Dias
,
Amélie Lansiaux
,
Christian Bailly
et al.
Journal articles
istex
hal-00169630v1
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Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
Cleopatra Neagoie
,
Emeline Vedrenne
,
Frédéric Buron
,
Jean-Yves Mérour
,
Sorin Rosca
et al.
Journal articles
istex
hal-00726237v1
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Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-l-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring—Potential Involvement of DNA Damage and Oxidative Stress
Anthony Laugeray
,
Asma Oummadi
,
Clément Jourdain
,
Justyne Feat
,
Géraldine Meyer-Dilhet
et al.
Journal articles
hal-02447420v1
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Convenient access to C-2 or C-5 substituted 4-azaindole derivatives
Fabienne Saab
,
Valerie Beneteau
,
Françoise Schoentgen
,
Jean-Yves Merour
,
Sylvain Routier
et al.
Tetrahedron, 2010, 66, pp.102-110
Journal articles
hal-00453412v1
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Controlled Dimroth Rearrangement in the Suzuki-Miyaura Cross Coupling of Triazolopyridopyrimidines.
Anthony Champiré
,
Christine Vala
,
Achraf Laabid
,
Ahmed Benharref
,
Mathieu Marchivie
et al.
Journal articles
hal-01432873v1
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Analytical developments for 47 pesticides: first identification of neutral chloroacetanilide derivatives in French groundwater
Laurence Amalric
,
Nicole Baran
,
Charlotte Coureau
,
Lucie Maingot
,
Frédéric Buron
et al.
Journal articles
hal-00975875v1
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Synthesis of Heterospirocycles through Gold‐(I) Catalysis, Useful Building Blocks for Medicinal Chemistry
Kossi Efouako Soklou
,
Hamid Marzag
,
Béatrice Vallée
,
Sylvain Routier
,
Karen Plé
et al.
Journal articles
hal-03411162v1
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Synthetic Route to Rare Isoindolones Derivatives
Killian Oukoloff
,
Frederic Buron
,
Sylvain Routier
,
Ludovic Jean
,
Pierre-Yves Renard
et al.
Journal articles
istex
hal-01150276v1
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Synthesis of 1,4-disubstituted pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyridazines by means of SNAr and palladium-catalysed reactions
Rabia Belaroussi
,
Ahmed El Hakmaoui
,
Nathalie Percina
,
Agnès Chartier
,
Mathieu Marchivie
et al.
Journal articles
istex
hal-01166893v1
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Aggressive behavior induced by the steroid sulfatase inhibitor COUMATE and by DHEAS in CBA/H mice
Laurent Nicolas
,
Walter Pinoteau
,
Sébastien Papot
,
Sylvain Routier
,
Gerald Guillaumet
et al.
Journal articles
istex
hal-02447524v1
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Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.
Pamela Kassis
,
Joanna Brzeszcz
,
Valérie Bénéteau
,
Olivier Lozach
,
Laurent Meijer
et al.
Journal articles
istex
hal-00720615v1
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Synthesis of novel series of 3,5-disubstituted imidazo[1,2- \textitd ] [1,2,4]thiadiazoles involving S _\textrmN Ar and Suzuki–Miyaura cross-coupling reactions
Clémentine Pescheteau
,
Matthieu Place
,
Alexandru Sava
,
Lea Nunes
,
Lenuta Profire
et al.
Journal articles
hal-03890856v1
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