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authFullName_s : Sylvain Routier

Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose

Béatrice Vallée , Karen Plé , A. Cosson , M. Doudeau , F. Godin et al.
Journée Fédération CBM-ICOA, Jan 2018, Orléans, France
Conference papers hal-02928530v1

First Palladium-Catalyzed Direct Regioselective C-5 (Het)Arylation of Mono- or Disubstituted Thiazolo[3,2- b ][1,2,4]triazoles

Mikaël Le Meur , Stéphane Bourg , Stéphane Massip , Mathieu Marchivie , Christian Jarry et al.
European Journal of Organic Chemistry, 2014, 2014 (17), pp.3704-3714. ⟨10.1002/ejoc.201402193⟩
Journal articles istex hal-02904759v1
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LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo

Rayan Berabez , Sylvain Routier , Hélène Bénédetti , Karen Plé , Béatrice Vallée et al.
Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩
Journal articles hal-03721458v1
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Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles

Kossi Efouako Soklou , Hamid Marzag , Jean-Philippe Bouillon , Mathieu Marchivie , Sylvain Routier et al.
Organic Letters, 2020, 22 (15), pp.5973-5977. ⟨10.1021/acs.orglett.0c02070⟩
Journal articles hal-02916186v1

Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action

Justine Corret , Sokaina Hammoud , Frédéric Buron , Pierre Daligaux , Christophe Chesné et al.
FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia
Conference poster hal-03679980v1

Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines

Vanessa Desplat , Marian Vincenzi , Romain Lucas , Stéphane Moreau , Solène Savrimoutou et al.
European Journal of Medicinal Chemistry, 2016, 113, pp.214-227. ⟨10.1016/j.ejmech.2016.02.047⟩
Journal articles hal-01307573v1

Multi Target directed ligands for the treatment of Alzheimer’s disease

Sovy Chao , Killian Oukoloff , Monika Bouet , Diego Muñoz Torrero , Jacques-Philippe Colletier et al.
Rencontres internationales de chimie thérapeutique (RICT, 52, 2016), Jul 2016, Caen, France
Conference poster hal-02544849v1

Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness

Pierre-Francois Cartron , Mathilde Cheray , Arulraj Nadaradjane , Pascal Bonnet , Sylvain Routier et al.
Epigenomics, 2014, 6 (3), pp.267-275. ⟨10.2217/epi.14.18⟩
Journal articles inserm-02478615v1

LIM kinases: new therapeutic targets to treat Neurofibromatosis type I

Béatrice Vallée , Michel Doudeau , Fabienne Godin , Anthony Champiré , Karen Plé et al.
The 7th EMBO meeting, Sep 2016, Mannheim, Germany.
Conference poster hal-02453490v1
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Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo

Shotaro Uehara , Makiko Shimizu , Karen Plé , Sylvain Routier , Nao Yoneda et al.
Drug Metabolism and Pharmacokinetics, 2022, 44, pp.100453. ⟨10.1016/j.dmpk.2022.100453⟩
Journal articles hal-03721472v1

Design of $\alpha$7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [$^{18}$F] quinuclidine derivative

Sylvie Mavel , Frédéric Pin , Johnny Vercouillie , Aziz Ouach , Zuhal Gulhan et al.
European Journal of Medicinal Chemistry, 2014, 82, pp.214 - 224. ⟨10.1016/j.ejmech.2014.04.057⟩
Journal articles hal-01826403v1
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Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

Frédéric Buron , Nuno Rodrigues , Thibault Saurat , Marie-Aude Hiebel , Stéphane Bourg et al.
Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Journal articles hal-03348966v1

Synthesis of γ-carboline N-oxide under gold(I)-catalysis and C-1 amino and fluoro γ-carboline

Zak Agnieszka , Hamid Marzag , Rodrigues Nuno , Vercouillie Johnny , Sylvie Chalon et al.
Tetrahedron, 2021, 89, pp.132154. ⟨10.1016/j.tet.2021.132154⟩
Journal articles hal-03717446v1
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30th Franco-Belgian conference of pharmacochemistry

Charlotte Bouckaert , Eric Goffin , Sebastien Dilly , Julien Hanson , Lionel Pochet et al.
Pharmaceuticals, 2016, 9 (4), pp.73. ⟨10.3390/ph9040073⟩
Journal articles hal-02141338v1

Oxidation of CuII to CuIII, Free Radical Production, and DNA Cleavage by Hydroxy-salen−Copper Complexes. Isomeric Effects Studied by ESR and Electrochemistry

Eric Lamour , Sylvain Routier , Jean-Luc Bernier , Jean-Pierre Catteau , Christian Bailly et al.
Journal of the American Chemical Society, 1999, Journal of the American Chemical Society, 121 (9), pp.1862-1869. ⟨10.1021/ja982221z⟩
Journal articles istex hal-03420210v1
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Development and preclinical evaluation of [18F]FBVM as a new potent PET tracer for vesicular acetylcholine transporter

Johnny Vercouillie , Frédéric Buron , Sophie Sérrière , Nuno Rodrigues , Zuhal Gulhan et al.
European Journal of Medicinal Chemistry, 2022, 244, pp.114794. ⟨10.1016/j.ejmech.2022.114794⟩
Journal articles hal-03881143v1
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Design and biological evaluation of substituted 5,7-dihydro-6 H -indolo[2,3- c ]quinolin-6-one as novel selective Haspin inhibitors

Sreenivas Avula , Xudan Peng , Xingfen Lang , Micky Tortorella , Béatrice Josselin et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37 (1), pp.1632-1650. ⟨10.1080/14756366.2022.2082419⟩
Journal articles hal-03818922v1

Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , A. Champiré et al.
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Conference poster hal-02924077v1

Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.

Sylvain Routier , Jean-Yves Mérour , Nathalie Dias , Amélie Lansiaux , Christian Bailly et al.
Journal of Medicinal Chemistry, 2006, 49 (2), pp.789-99. ⟨10.1021/jm050945x⟩
Journal articles istex hal-00169630v1

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.

Cleopatra Neagoie , Emeline Vedrenne , Frédéric Buron , Jean-Yves Mérour , Sorin Rosca et al.
European Journal of Medicinal Chemistry, 2012, 49, pp.379-96. ⟨10.1016/j.ejmech.2012.01.040⟩
Journal articles istex hal-00726237v1

Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-l-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring—Potential Involvement of DNA Damage and Oxidative Stress

Anthony Laugeray , Asma Oummadi , Clément Jourdain , Justyne Feat , Géraldine Meyer-Dilhet et al.
Neurotoxicity Research, 2018, 33 (1), pp.87-112. ⟨10.1007/s12640-017-9802-1⟩
Journal articles hal-02447420v1

Convenient access to C-2 or C-5 substituted 4-azaindole derivatives

Fabienne Saab , Valerie Beneteau , Françoise Schoentgen , Jean-Yves Merour , Sylvain Routier et al.
Tetrahedron, 2010, 66, pp.102-110
Journal articles hal-00453412v1

Controlled Dimroth Rearrangement in the Suzuki-Miyaura Cross Coupling of Triazolopyridopyrimidines.

Anthony Champiré , Christine Vala , Achraf Laabid , Ahmed Benharref , Mathieu Marchivie et al.
Journal of Organic Chemistry, 2016, 81 (24), pp.12506-12513. ⟨10.1021/acs.joc.6b02357⟩
Journal articles hal-01432873v1

Analytical developments for 47 pesticides: first identification of neutral chloroacetanilide derivatives in French groundwater

Laurence Amalric , Nicole Baran , Charlotte Coureau , Lucie Maingot , Frédéric Buron et al.
International Journal of Environmental Analytical Chemistry, 2013, 93 (15), pp.1660-1675. ⟨10.1080/03067319.2013.853758⟩
Journal articles hal-00975875v1
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Synthesis of Heterospirocycles through Gold‐(I) Catalysis, Useful Building Blocks for Medicinal Chemistry

Kossi Efouako Soklou , Hamid Marzag , Béatrice Vallée , Sylvain Routier , Karen Plé et al.
Advanced Synthesis and Catalysis, 2021, ⟨10.1002/adsc.202101080⟩
Journal articles hal-03411162v1

Synthetic Route to Rare Isoindolones Derivatives

Killian Oukoloff , Frederic Buron , Sylvain Routier , Ludovic Jean , Pierre-Yves Renard et al.
European Journal of Organic Chemistry, 2015, 2015 (11), pp.2450-2456. ⟨10.1002/ejoc.201403649⟩
Journal articles istex hal-01150276v1

Synthesis of 1,4-disubstituted pyrido[1′,2′:1,5]pyrazolo[3,4-d]pyridazines by means of SNAr and palladium-catalysed reactions

Rabia Belaroussi , Ahmed El Hakmaoui , Nathalie Percina , Agnès Chartier , Mathieu Marchivie et al.
European Journal of Inorganic Chemistry, 2015, 18, pp.4006-4017. ⟨10.1002/ejoc.201500294⟩
Journal articles istex hal-01166893v1

Aggressive behavior induced by the steroid sulfatase inhibitor COUMATE and by DHEAS in CBA/H mice

Laurent Nicolas , Walter Pinoteau , Sébastien Papot , Sylvain Routier , Gerald Guillaumet et al.
Brain Research, 2001, 922 (2), pp.216-222. ⟨10.1016/s0006-8993(01)03171-7⟩
Journal articles istex hal-02447524v1

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.

Pamela Kassis , Joanna Brzeszcz , Valérie Bénéteau , Olivier Lozach , Laurent Meijer et al.
European Journal of Medicinal Chemistry, 2011, 46 (11), pp.5416-34. ⟨10.1016/j.ejmech.2011.08.048⟩
Journal articles istex hal-00720615v1

Synthesis of novel series of 3,5-disubstituted imidazo[1,2- \textitd ] [1,2,4]thiadiazoles involving S _\textrmN Ar and Suzuki–Miyaura cross-coupling reactions

Clémentine Pescheteau , Matthieu Place , Alexandru Sava , Lea Nunes , Lenuta Profire et al.
RSC Advances, 2022, 12 (10), pp.6303--6313. ⟨10.1039/D1RA07208K⟩
Journal articles hal-03890856v1