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authFullName_s : Yann Humeau

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway

Malik Khelfaoui , Frédéric Gambino , Xander Houbaert , Bruno Ragazzon , Christian Muller et al.
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014, 369 (1633), pp.20130160. ⟨10.1098/rstb.2013.0160⟩
Journal articles hal-02392406v1

Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability

Hamid Meziane , Malik Khelfaoui , Noemi Morello , Bassem Hiba , Eleonora Calcagno et al.
Human Molecular Genetics, 2016, 25 (11), pp.2314-2323. ⟨10.1093/hmg/ddw102⟩
Journal articles hal-02404671v1

X-linked mental retardation: focus on synaptic function and plasticity

Yann Humeau , Frédéric Gambino , Jamel Chelly , Nicolas Vitale
Journal of Neurochemistry, 2009, 109 (1), pp.1-14. ⟨10.1111/j.1471-4159.2009.05881.x⟩
Journal articles hal-02392419v1
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Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology

Lam Son Nguyen , Marylin Lepleux , Mélanie Makhlouf , Christelle Martin , Julien Fregeac et al.
Molecular Autism, 2016, 7 (1), pp.1. ⟨10.1186/s13229-015-0064-6⟩
Journal articles inserm-01252689v1

Non-linear dendritic integration in frontal circuits shapes sensory discrimination in rodents

Mattia Aime , Elisabete Augusto , Vladimir Kouskoff , Christelle Martin , Yann Humeau et al.
2019
Preprints, Working Papers, ... hal-02392397v1

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway

Malik Khelfaoui , Frédéric Gambino , Xander Houbaert , Bruno Ragazzon , Christian Müller et al.
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014, 369 (1633), pp.20130160. ⟨10.1098/rstb.2013.0160⟩
Journal articles hal-03367917v1
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Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition

Thomas Arbogast , G Iacono , C Chevalier , N Afinowi , X Houbaert et al.
PLoS Genetics, 2017, 13 (7), ⟨10.1371/journal.pgen.1006886⟩
Journal articles hal-03679164v1

A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations

Aline Dubos , Hamid Meziane , Giovanni Iacono , Aurore Curie , Fabrice Riet et al.
Human Molecular Genetics, 2018, 27 (12), pp.2138-2153. ⟨10.1093/hmg/ddy122⟩
Journal articles hal-03664342v1

The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability

Chun-Lei Zhang , Xander Houbaert , Marilyn Lepleux , Melissa Deshors , Elisabeth Normand et al.
Brain Structure and Function, 2015, 220 (6), pp.3673-3682. ⟨10.1007/s00429-014-0882-x⟩
Journal articles hal-02392401v1

Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder.

Xander Houbaert , C.L. Zhang , Frédéric Gambino , Marylin Lepleux , Melissa Deshors et al.
Journal of Neuroscience, 2013, ⟨10.1523/JNEUROSCI⟩
Journal articles hal-02392407v1

High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning

Angela Getz , Mathieu Ducros , Christelle Breillat , Aurélie Lampin-Saint-Amaux , Sophie Daburon et al.
Science Advances , 2022, Neuromethods, 8 (30), pp.159-191. ⟨10.1126/sciadv.abm5298⟩
Journal articles hal-03864975v1

A Rho-related GTPase is involved in Ca2+-dependent neurotransmitter exocytosis

Frederic Doussau , Stephane Gasman , Yann Humeau , Francesco Vitiello , Michel Popoff et al.
Journal of Biological Chemistry, 2000, 275 (11), pp.7764-7770. ⟨10.1074/jbc.275.11.7764⟩
Journal articles hal-02922237v1
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Functional roles of synapsin: lessons from invertebrates.

Yann Humeau , Simona Candiani , Mirella Ghirardi , Bernard Poulain , Piergiorgo Montarolo et al.
Seminars in cell & developmental biology, 2011, 22 (4), pp.425-433. ⟨10.1016/j.semcdb.2011.07.018⟩
Journal articles hal-02933961v1

Protein Kinase A deregulation in the medial prefrontal cortex impairs working memory in murine Oligophrenin1 deficiency

Chun-Lei Zhang , Mattia Aime , Emilie Laheranne , Xander Houbaert , Hajer El Oussini et al.
Journal of Neuroscience, 2017, 37 (46), pp.11114-11126. ⟨10.1523/JNEUROSCI.0351-17.2017⟩
Journal articles hal-03677819v1

Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling

Rajesh Jayachandran , Xiaolong Liu , Somdeb Bosedasgupta , Philipp Müller , Chun-Lei Zhang et al.
PLoS Biology, 2014, 12 (3), pp.e1001820. ⟨10.1371/journal.pbio.1001820⟩
Journal articles hal-02392404v1

The next generation of approaches to investigate the link between synaptic plasticity and learning.

Yann Humeau , Daniel Choquet
Nature Neuroscience, 1970, 22 (10), pp.1536-1543. ⟨10.1038/s41593-019-0480-6⟩
Journal articles hal-03024353v1
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The integration of Gaussian noise by long-range amygdala inputs in frontal circuit promotes fear learning in mice

Mattia Aime , Elisabete Augusto , Vladimir Kouskoff , Tiago Campelo , Christelle Martin et al.
Journal articles hal-03032386v1
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Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models

Hongyu Zhang , Chunlei Zhang , Jean Vincent , Diana Zala , Caroline Benstaali et al.
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06675-3⟩
Journal articles hal-02325352v1

Synaptic Maturation at Cortical Projections to the Lateral Amygdala in a Mouse Model of Rett Syndrome

Frédéric Gambino , Malik Khelfaoui , Bernard Poulain , Thierry Bienvenu , Jamel Chelly et al.
PLoS ONE, 2010, 5 (7), pp.e11399. ⟨10.1371/journal.pone.0011399⟩
Journal articles hal-02392415v1

High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning

Angela Getz , Mathieu Ducros , Christelle Breillat , Aurélie Lampin-Saint-Amaux , Sophie Daburon et al.
Science Advances , 2022, 8 (30), ⟨10.1126/sciadv.abm5298⟩
Journal articles hal-03784609v1

L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala

Elodie Fourcaudot , Frédéric Gambino , Guillaume Casassus , Bernard Poulain , Yann Humeau et al.
Nature Neuroscience, 2009, 12 (9), pp.1093-1095. ⟨10.1038/nn.2378⟩
Journal articles hal-02392417v1

In Vivo Manipulations to Correct for Behavioral Phenotypes in Cognitive Disorder Mouse Models

Chun-Lei Zhang , Mattia Aime , Yann Humeau
Translational Research Methods in Neurodevelopmental Disorders, 185, Springer US, pp.159-191, 2022, Neuromethods, ⟨10.1007/978-1-0716-2569-9_9⟩
Book sections hal-03864982v1

IL1RAPL1 controls inhibitory networks during cerebellar development in mice

Frédéric Gambino , Marie Kneib , Alice Pavlowsky , Henriette Skala , Stéphane Heitz et al.
European Journal of Neuroscience, 2009, 30 (8), pp.1476-1486. ⟨10.1111/j.1460-9568.2009.06975.x⟩
Journal articles istex hal-02392416v1

High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning

Angela Getz , Mathieu Ducros , Christelle Breillat , Aurélie Lampin-Saint-Amaux , Sophie Daburon et al.
Science Advances , 2022, 8 (30), ⟨10.1126/sciadv.abm5298⟩
Journal articles hal-03864953v1
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The integration of Gaussian noise by long-range amygdala inputs in frontal circuit promotes fear learning

Mattia Aime , Elisabete Augusto , Vladimir Kouskoff , Christelle Martin , Yann Humeau et al.
2020
Preprints, Working Papers, ... hal-03006642v1

Synaptic dysfunction in amygdala in intellectual disorder models

Marianne Aincy , Hamid Meziane , Yann Herault , Yann Humeau
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2018, 84, pp.392-397. ⟨10.1016/j.pnpbp.2017.07.028⟩
Journal articles hal-03065430v1
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A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency

Xiao Min Zhang , Urielle François , Katlin Silm , Maria Florencia Angelo , Maria Victoria Fernandez-Busch et al.
eLife, 2019, 8, pp.e50401. ⟨10.7554/eLife.50401⟩
Journal articles hal-02365471v1
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Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis

Mariana Ramos-Brossier , Caterina Montani , Nicolas Lebrun , Laura Gritti , Christelle Martin et al.
Human Molecular Genetics, 2014, pp.523
Journal articles inserm-01102927v1
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Abnormal AMPAR-mediated synaptic plasticity, cognitive and autistic-like behaviors in a missense Fmr1 mutant mouse model of Fragile X syndrome

Marta Prieto , Alessandra Folci , Gwénola Poupon , Sara Schiavi , Valeria Buzzelli et al.
2020
Preprints, Working Papers, ... hal-03039153v1
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Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice

Marta Prieto , Alessandra Folci , Gwénola Poupon , Sara Schiavi , Valeria Buzzelli et al.
Nature Communications, 2021, 12 (1), pp.1557. ⟨10.1038/s41467-021-21820-1⟩
Journal articles inserm-03172160v1