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Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.

Gilles Labesse , Khaled Benkali , Isabelle Salard-Arnaud , Anne-Marie Gilles , Hélène Munier-Lehmann et al.
Nucleic Acids Research, 2011, 39 (8), pp.3458-72. ⟨10.1093/nar/gkq1250⟩
Journal articles pasteur-00589535v1

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.

Annemarie Wehenkel , Pablo Fernandez , Marco Bellinzoni , Vincent Catherinot , Nathalie Barilone et al.
FEBS Letters, 2006, 580 (13), pp.3018-22. ⟨10.1016/j.febslet.2006.04.046⟩
Journal articles istex pasteur-03144516v1

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.

Claire Amiable , Julie Paoletti , Ahmed Haouz , André Padilla , Gilles Labesse et al.
European Journal of Medicinal Chemistry, 2014, 85, pp.418-37. ⟨10.1016/j.ejmech.2014.07.110⟩
Journal articles pasteur-01483767v1

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes.

Hélène Munier-Lehmann , Alain Chaffotte , Sylvie Pochet , Gilles Labesse
Protein Science, 2001, 10 (6), pp.1195-205. ⟨10.1110/ps.45701⟩
Journal articles pasteur-00167069v1

Crystal Structure of MabA from Mycobacterium tuberculosis, a Reductase involved in Long-chain Fatty Acid Biosynthesis

Martin Cohen-Gonsaud , Stéphanie Ducasse , Francois Hoh , Didier Zerbib , Gilles Labesse et al.
Journal of Molecular Biology, 2002, 320 (2), pp.249-261. ⟨10.1016/S0022-2836(02)00463-1⟩
Journal articles istex hal-02359522v1

Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding

Melanie Schneider , Vanessa Delfosse , Muriel Gelin , Marina Grimaldi , Meritxell Granell et al.
Journal of Medicinal Chemistry, 2022, 65 (2), pp.1552-1566. ⟨10.1021/acs.jmedchem.1c01354⟩
Journal articles hal-03795558v1

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Sylvie Pochet , Laurence Dugué , Dominique Douguet , Gilles Labesse , Hélène Munier-Lehmann et al.
Journal articles istex pasteur-00166196v1

Rho-GTPase-activating Protein Interacting with Cdc-42-interacting Protein 4 Homolog 2 (Rich2)

F. Raynaud , Enora Moutin , Vincent Compan , Caroline Clerté , Nathalie Bouquier et al.
Journal of Biological Chemistry, 2014, 289 (5), pp.2600-2609. ⟨10.1074/jbc.m113.534636⟩
Journal articles hal-03674325v1
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N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.

Claire Amiable , Sylvie Pochet , André Padilla , Gilles Labesse , Pierre-Alexandre Kaminski et al.
PLoS ONE, 2013, 8 (11), pp.e80755. ⟨10.1371/journal.pone.0080755.t003⟩
Journal articles pasteur-01472730v1
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A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasma and Anti-Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice

Delphine Jublot , Pierre Cavaillès , Salima Kamche , Denise Francisco , Diana Fontinha et al.
International Journal of Molecular Sciences, 2022, 23 (6), pp.3254. ⟨10.3390/ijms23063254⟩
Journal articles hal-03818209v1
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A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene

Isabelle Meunier , Béatrice Bocquet , Gilles Labesse , Christina Zeitz , Sabine Defoort-Dhellemmes et al.
Scientific Reports, 2016, Scientific reports, 6, pp.32544. ⟨10.1038/srep32544⟩
Journal articles hal-01824596v1
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Characterization of the mechanisms controlling Greatwall activity.

Suzanne Vigneron , Aicha Gharbi-Ayachi , Anne-Aurélie Raymond , Andrew Burgess , Jean-Claude Labbé et al.
Molecular and Cellular Biology, 2011, 31 (11), pp.2262-75. ⟨10.1128/MCB.00753-10⟩
Journal articles hal-00649525v1
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Comprehensive classification of the plant non-specific lipid transfer protein superfamily towards its Sequence -Structure -Function analysis

Cécile Fleury , Jérôme Gracy , Marie-Françoise Gautier , Jean-Luc Pons , Jean-François Dufayard et al.
PeerJ, 2019, 7, pp.e7504. ⟨10.7287/peerj.preprints.27687v1⟩
Journal articles hal-02112505v1

Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors.

Yinshan Yang , André Padilla , Chi Zhang , Gilles Labesse , Pierre-Alexandre Kaminski et al.
Journal of Molecular Biology, 2009, 394 (3), pp.435-47. ⟨10.1016/j.jmb.2009.10.004⟩
Journal articles pasteur-03726707v1

Screening and In Situ Synthesis Using Crystals of a NAD Kinase Lead to a Potent Antistaphylococcal Compound

Muriel Gelin , Guillaume Poncet-Montange , Liliane Assairi , Laurence Morellato , Valérie Huteau et al.
Structure, 2012, 20 (6), pp.1107 - 1117. ⟨10.1016/j.str.2012.03.024⟩
Journal articles hal-02648096v1
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Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity

Sébastien Sagnol , Yinshan Yang , Yannick Bessin , Frédéric Allemand , Ilona Hapkova et al.
Nucleic Acids Research, 2014, ⟨10.1093/nar/gku692⟩
Journal articles hal-02543654v1

The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modeling.

Hiba El Hajj , Emmanuelle Demey , Joël Poncet , Maryse Lebrun , Bo Wu et al.
Proteomics, 2006, 6 (21), pp.5773-84. ⟨10.1002/pmic.200600187⟩
Journal articles istex hal-00167426v1

Internal point mutations of the capsid modify the serotype of Rice yellow mottle virus.

Eugénie Hébrard , Agnès Pinel-Galzi , Vincent Catherinot , Gilles Labesse , Christophe Brugidou et al.
Journal of Virology, 2005, 79 (7), pp.4407-14. ⟨10.1128/JVI.79.7.4407-4414.2005⟩
Journal articles hal-00168833v1

Structural and nucleotide-binding properties of YajQ and YnaF, two Escherichia coli proteins of unknown function

Cosmin Saveanu , Simona Miron , Tudor Borza , Constantin T. Craescu , Gilles Labesse et al.
Protein Science, 2002, 11 (11), pp.2551--2560. ⟨10.1110/ps.0217502⟩
Journal articles pasteur-01404701v1

ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.

Gilles Labesse , Muriel Gelin , Yannick Bessin , Maryse Lebrun , Julien Papoin et al.
Structure, 2009, 17 (1), pp.139-46. ⟨10.1016/j.str.2008.11.005⟩
Journal articles hal-00373662v1

A dominant mutation in MAPKAPK3 , an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium

Isabelle Meunier , Guy Lenaers , Beatrice Bocquet , Corinne Baudoin , Camille Piro-Megy et al.
Human Molecular Genetics, 2016, 25 (5), pp.916 - 926. ⟨10.1093/hmg/ddv624⟩
Journal articles hal-01882151v1
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An oligomeric switch controls the Mrr-induced SOS response in E. coli

Anaïs C Bourges , Oscar E Torres Montaguth , Wubishet Tadesse , Gilles Labesse , Abram Aertsen et al.
DNA Repair, 2021, 97, pp.103009. ⟨10.1016/j.dnarep.2020.103009⟩
Journal articles hal-03015076v1

New compounds for the treatment and/or prevention of parasitic diseases and method of production of thereof

Denis Sereno , Gilles Labesse , Jean-François Guichon , Corinne Loeuillet , Deborah Gracia et al.
France, Patent n° : EP N° 13177129.7. 2013
Patents hal-00918009v1
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Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes.

Vanessa Delfosse , Marina Grimaldi , Jean-Luc Pons , Abdelhay Boulahtouf , Albane Le Maire et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012, epub ahead of print. ⟨10.1073/pnas.1203574109⟩
Journal articles inserm-00726779v1
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Phosphodeoxyribosyltransferases: designed enzymes for deoxyribonucleotide synthesis.

Pierre-Alexandre Kaminski , Gilles Labesse
Journal of Biological Chemistry, 2013, 288 (9), pp.6534-6541. ⟨10.1074/jbc.M112.446492⟩
Journal articles pasteur-00796440v1
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The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop

Jean Claude Labbé , Suzanne Vigneron , Francisca Méchali , Perle Robert , Sylvain Roque et al.
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-23657-0⟩
Journal articles hal-03263787v1
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Structure-based design of NAD+ analogues targeting bacterial NAD kinases, promising targets for new antibiotics

Rahila Rahimova , Pauline Nogaret , Valérie Huteau , Clarisse Leseigneur , Muriel Gelin et al.
The Biochemistry Global Summit, 25th IUBMB Congress, 46th FEBS Congress, 15th PABMB Congress, Portuguese Biochemical Society (SPB); IUBMB; FEBS; PABMB, Jul 2022, Lisbon, Portugal. pp.24, ⟨10.1002/2211-5463.13442⟩
Conference papers hal-03854164v1
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Probing Protein Interaction Networks by Combining MS-Based Proteomics and Structural Data Integration

Guillaume Postic , Julien Marcoux , Victor Reys , Jessica Andreani , Yves Vandenbrouck et al.
Journal of Proteome Research, 2020, 19 (7), pp.2807-2820. ⟨10.1021/acs.jproteome.0c00066⟩
Journal articles hal-02571410v1
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Non-classical ligand-independent regulation of Go protein by an orphan Class C GPCR

Mariana Hajj , Teresa de Vita , Claire Vol , Charlotte Renassia , Jean-Charles Bologna et al.
Molecular Pharmacology, 2019, 96 (2), pp.233-246. ⟨10.1124/mol.118.113019⟩
Journal articles hal-02396282v1
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A 20-amino acid module of protein kinase C{epsilon} involved in translocation and selective targeting at cell-cell contacts.

Barthélémy Diouf , Alejandra Collazos , Gilles Labesse , Françoise Macari , Armelle Choquet et al.
Journal of Biological Chemistry, 2009, 284 (28), pp.18808-15. ⟨10.1074/jbc.M109.004614⟩
Journal articles hal-00423750v1