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Rapid optical control of nociception with an ion-channel photoswitch

Alexandre Mourot , Timm Fehrentz , Yves Le Feuvre , Caleb M. Smith , Christian Herold et al.
Nature Methods, 2012, 9 (4), pp.396-U114. ⟨10.1038/NMETH.1897⟩
Journal articles hal-01542262v1
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Linking YAP to Müller Glia Quiescence Exit in the Degenerative Retina

Annaïg Hamon , Diana García-García , Divya Ail , Juliette Bitard , Albert Chesneau et al.
Cell Reports, 2019, 27 (6), pp.1712-1725.e6. ⟨10.1016/j.celrep.2019.04.045⟩
Journal articles hal-02136721v1
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Control of Microbial Opsin Expression in Stem Cell Derived Cones for Improved Outcomes in Cell Therapy

Marcela Garita-Hernandez , Antoine Chaffiol , Laure Guibbal , Fiona Routet , Hanen Khabou et al.
Frontiers in Cellular Neuroscience, 2021, 15, pp.648210. ⟨10.3389/fncel.2021.648210⟩
Journal articles hal-03203975v1
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Gene therapy for retinal dystrophy

José-Alain Sahel , Deniz Dalkara
Nature Medicine, 2019
Journal articles hal-03262281v1
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New Editing Tools for Gene Therapy in Inherited Retinal Dystrophies

Juliette Pulman , José-Alain Sahel , Deniz Dalkara
The CRISPR Journal, 2022, ⟨10.1089/crispr.2021.0141⟩
Journal articles hal-03663282v1
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The thioredoxin encoded by the Rod-derived Cone Viability Factor gene protects cone photoreceptors against oxidative stress

Xin Mei , Antoine Chaffiol , Christo Kole , Ying Yang , Géraldine Millet-Puel et al.
Antioxidants and Redox Signaling, 2016, ⟨10.1089/ars.2015.6509⟩
Journal articles hal-01297482v1
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AAV-mediated gene therapy in Dystrophin-Dp71 deficient mouse leads to blood-retinal barrier restoration and oedema reabsorption

Ophélie Vacca , Hugo Charles-Messance , Brahim El Mathari , Abdoulaye Sene , Peggy Barbe et al.
Human Molecular Genetics, 2016, 25 (14), pp.3070-79. ⟨10.1093/hmg/ddw159⟩
Journal articles hal-01358629v1
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Intracisternal delivery of NFκB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment

Olivier Bockstael , Liliane Tenenbaum , Deniz Dalkara , Catherine Melas , Olivier de Witte et al.
Frontiers in Molecular Neuroscience, 2014, 7, pp.92. ⟨10.3389/fnmol.2014.00092⟩
Journal articles hal-01321288v1

Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in a foraging task

Malou Dongelmans , Romain Durand-de Cuttoli , Claire Nguyen , Maxime Come , Etienne Duranté et al.
Preprints, Working Papers, ... hal-03379664v1
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Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice

Malou Dongelmans , Romain Durand-de Cuttoli , Claire Nguyen , Maxime Come , Etienne K Duranté et al.
Nature Communications, 2021, 12 (1), pp.6945. ⟨10.1038/s41467-021-27268-7⟩
Journal articles hal-03839427v1
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Vectors and Gene Delivery to the Retina

Arthur Planul , Deniz Dalkara
Annual Review of Vision Science, 2017, 3 (1), pp.121 - 140. ⟨10.1146/annurev-vision-102016-061413⟩
Journal articles hal-01676341v1
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Towards optogenetic vision restoration with high resolution

Ulisse Ferrari , Stéphane Deny , Abhishek Sengupta , Romain Caplette , Francesco Trapani et al.
PLoS Computational Biology, 2020, 16 (7), pp.e1007857. ⟨10.1371/journal.pcbi.1007857⟩
Journal articles hal-02934769v1
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Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques

Benjamin Dehay , Deniz Dalkara , Sandra Dovero , Qin Li , Erwan Bézard et al.
Scientific Reports, 2012, 2, pp.253. ⟨10.1038/srep00253⟩
Journal articles inserm-02439214v1
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The primate model for understanding and restoring vision

Serge Picaud , Deniz Dalkara , Katia Marazova , Olivier Goureau , Botond Roska et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019, ⟨10.1073/pnas.1902292116⟩
Journal articles hal-03127682v1
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The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function

Céline Jaillard , Farah Ouechtati , Emmanuelle Clérin , Géraldine Millet-Puel , Mariangela Corsi et al.
Redox Biology, 2021, 48, pp.102198. ⟨10.1016/j.redox.2021.102198⟩
Journal articles hal-03465154v1

Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering RNA.

Jérôme Courtête , Annie-Paule Sibler , Gabrielle Zeder-Lutz , Deniz Dalkara , Mustapha Oulad-Abdelghani et al.
Molecular Cancer Therapeutics, 2007, 6 (6), pp.1728-35. ⟨10.1158/1535-7163.MCT-06-0808⟩
Journal articles hal-00189366v1
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The temporal structure of the inner retina at a single glance

Zhijian Zhao , David A Klindt , André Maia Chagas , Klaudia P Szatko , Luke Rogerson et al.
Scientific Reports, 2020, 10 (1), pp.4399. ⟨10.1038/s41598-020-60214-z⟩
Journal articles inserm-02510738v1
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Optogenetic Light Sensors in Human Retinal Organoids

Marcela Garita-Hernandez , Laure Guibbal , Lyes Toualbi , Fiona Routet , Antoine Chaffiol et al.
Frontiers in Neuroscience, 2018, 12, pp.789. ⟨10.3389/fnins.2018.00789⟩
Journal articles hal-01926863v1
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Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71

Mirella Telles Salgueiro Barboni , Cyrille Vaillend , Anneka Joachimsthaler , André Maurício Passos Liber , Hanen Khabou et al.
Investigative Ophthalmology & Visual Science, 2020, 61 (2), pp.11. ⟨10.1167/iovs.61.2.11⟩
Journal articles hal-02520616v1
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Dosage Thresholds and Influence of Transgene Cassette in Adeno-Associated Virus–Related Toxicity

Hanen Khabou , Chloé Cordeau , Laure Pacot , Sylvain Fisson , Deniz Dalkara et al.
Human Gene Therapy, 2018, 0, ⟨10.1089/hum.2018.144⟩
Journal articles hal-01927077v1

Outer retinal transduction by AAV2-7m8 following intravitreal injection in a sheep model of CNGA3 achromatopsia

M. Ross , A. Obolensky , E. Averbukh , M. Desrosiers , R. Ezra-Elia et al.
Gene Therapy, 2022, 29 (10-11), pp.624-635. ⟨10.1038/s41434-021-00306-1⟩
Journal articles hal-03897126v1
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In vivo sub-millisecond two-photon optogenetics with temporally focused patterned light

I-Wen Chen , Emiliano Ronzitti , Brian R Lee , Tanya Daigle , Deniz Dalkara et al.
Journal of Neuroscience, 2019, 39 (18), pp.3484-3497. ⟨10.1523/JNEUROSCI.1785-18.2018⟩
Journal articles inserm-02119932v1
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A new promoter allows optogenetic vision restoration with enhanced sensitivity in macaque retina

Antoine Chaffiol , Romain P Caplette , Céline Jaillard , Elena Brazhnikova , Mélissa Desrosiers et al.
Molecular Therapy, 2017, 25 (11), pp.2546-2560. ⟨10.1016/j.ymthe.2017.07.011⟩
Journal articles hal-01844782v1
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Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

Gregory Gauvain , Himanshu Akolkar , Antoine Chaffiol , Fabrice Arcizet , Mina A Khoei et al.
Communications Biology, 2021, 4 (1), pp.125. ⟨10.1038/s42003-020-01594-w⟩
Journal articles hal-03125732v1
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Neural circuits in the mouse retina support color vision in the upper visual field

Klaudia P Szatko , Maria M Korympidou , Yanli Ran , Philipp Berens , Deniz Dalkara et al.
Nature Communications, 2020, 11 (1), pp.3481. ⟨10.1038/s41467-020-17113-8⟩
Journal articles inserm-02907233v1
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Partial recovery of visual function in a blind patient after optogenetic therapy

José-Alain Sahel , Elise Boulanger-Scemama , Chloé Pagot , Angelo Arleo , Francesco Galluppi et al.
Nature Medicine, 2021, ⟨10.1038/s41591-021-01351-4⟩
Journal articles hal-03269200v1

Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis

Najate Aït-Ali , Ram Fridlich , Géraldine Millet-Puel , Emmanuelle Clérin , François Delalande et al.
Cell, 2015, 161 (4), pp.817-832. ⟨10.1016/j.cell.2015.03.023⟩
Journal articles hal-01194945v1
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Linking YAP to Müller Glia Quiescence Exit in the Degenerative Retina

Annaïg Hamon , Diana García-García , Divya Ail , Juliette Bitard , Albert Chesneau et al.
Cell Reports, 2019, 27 (6), pp.1712 - 1725.e6. ⟨10.1016/j.celrep.2019.04.045⟩
Journal articles hal-03043321v1
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AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells

Marcela Garita-Hernandez , Fiona Routet , Laure Guibbal , Hanen Khabou , Lyes Toualbi et al.
International Journal of Molecular Sciences, 2020, 21 (3), pp.994. ⟨10.3390/ijms21030994⟩
Journal articles hal-02538406v1
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Genotypic and Phenotypic Characterization of P23H Line 1 Rat Model

Elise Orhan , Deniz Dalkara , Marion Neuillé , Christophe Lechauve , Christelle Michiels et al.
PLoS ONE, 2015, 10 (5), pp.e0127319. ⟨10.1371/journal.pone.0127319⟩
Journal articles hal-01228055v1