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Multiple Cross Talk between Angiotensin II, Bradykinin, and Insulin Signaling in the Cortical Thick Ascending Limb of Rat Kidney

Annette Hus-Citharel , Nadine Bouby , Xavier Iturrioz , Catherine Llorens-Cortes
Endocrinology, 2010, 151 (7), pp.3181-3194. ⟨10.1210/en.2009-1237⟩
Journal articles hal-03631040v1

Tyrosine Kinase and Mitogen-Activated Protein Kinase/Extracellularly Regulated Kinase Differentially Regulate Intracellular Calcium Concentration Responses to Angiotensin II/III and Bradykinin in Rat Cortical Thick Ascending Limb

Annette Hus-Citharel , Xavier Iturrioz , Pierre Corvol , Jeannine Marchetti , Catherine Llorens-Cortes et al.
Endocrinology, 2006, 147 (1), pp.451-463. ⟨10.1210/en.2005-0253⟩
Journal articles hal-03631052v1

Structural insight into the catalytic mechanism and inhibitor binding of aminopeptidase A

Pierre Couvineau , Hugo de Almeida , Vincent Leroux , Bernard Roques , Bernard Maigret et al.
Biochemical Journal, 2020, 477 (21), pp.4133-4148. ⟨10.1042/BCJ20200307⟩
Journal articles hal-03029058v1

Contribution of Molecular Modeling and Site-Directed Mutagenesis to the Identification of a New Residue, Glutamate 215, Involved in the Exopeptidase Specificity of Aminopeptidase A

Raphaël Rozenfeld , Xavier Iturrioz , Mayumi Okada , Bernard Maigret , Catherine Llorens-Cortes et al.
Biochemistry, 2003, 42 (50), pp.14785-14793. ⟨10.1021/bi034358u⟩
Journal articles istex hal-03631059v1
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A snake toxin as a theranostic agent for the type 2 vasopressin receptor

Laura Droctové , Manon Lancien , Vu Long Tran , Michaël Susset , Benoit Jego et al.
Theranostics, 2020, 10 (25), pp.11580-11594. ⟨10.7150/thno.47485⟩
Journal articles hal-02960704v1
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LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Adrien Flahault , Mathilde Keck , Pierre-Emmanuel Girault-Sotias , Lucie Esteoulle , Nadia de Mota et al.
Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.715095⟩
Journal articles hal-03322968v1

A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension

Michel Azizi , Pierre-Yves Courand , Thierry Denolle , Pascal Delsart , Valentina Zhygalina et al.
Journal of Hypertension, 2019, 37 (8), pp.1722-1728. ⟨10.1097/HJH.0000000000002092⟩
Journal articles hal-03149099v1

Tyrosine kinase and mitogen-activated protein kinase/extracellularly regulated kinase differentially regulate intracellular calcium concentration responses to angiotensin II/III and bradykinin in rat cortical thick ascending limb.

Annette Hus-Citharel , Xavier Iturrioz , Pierre Corvol , Jeannine Marchetti , Catherine Llorens-Cortes et al.
Endocrinology, 2006, 147 (1), pp.451-63. ⟨10.1210/en.2005-0253⟩
Journal articles inserm-00423374v1

Orally Active Aminopeptidase A Inhibitor Prodrugs: Current State and Future Directions

Mathilde Keck , Reda Hmazzou , Catherine Llorens-Cortes
Current Hypertension Reports, 2019, 21 (7), pp.50. ⟨10.1007/s11906-019-0957-4⟩
Journal articles inserm-02262448v1

Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity

Cédric Claperon , Raphael Rozenfeld , Xavier Iturrioz , Nicolas Inguimbert , Mayumi Okada et al.
Biochemical Journal, 2008, 416 (1), pp.37-46. ⟨10.1042/BJ20080471⟩
Journal articles hal-03631043v1
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Brain renin-angiotensin system blockade with orally active aminopeptidase A inhibitor prevents cardiac dysfunction after myocardial infarction in mice

Solène Emmanuelle Boitard , Yannick Marc , Mathilde Keck , Nathalie Mougenot , Onnik Agbulut et al.
Journal of Molecular and Cellular Cardiology, 2019, 127, pp.215-222. ⟨10.1016/j.yjmcc.2018.12.008⟩
Journal articles hal-02265448v1

Role of angiotensin III in hypertension

Annabelle Reaux-Le Goazigo , Xavier Iturrioz , Celine Fassot , Cedric Claperon , Bernard Roques et al.
Current Hypertension Reports, 2005, 7 (2), pp.128-134. ⟨10.1007/s11906-005-0087-z⟩
Journal articles hal-03631055v1

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Christelle David , Laurent Bischoff , Hervé Meudal , Aurélie Mothé , Nadia de Mota et al.
Journal of Medicinal Chemistry, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩
Journal articles istex hal-02122148v1

Roles of brain angiotensins II and III in thirst and sodium appetite.

Wendy L. Wilson , Bernard P. Roques , Catherine Llorens-Cortes , Robert C. Speth , Joseph W. Harding et al.
Brain Research, 2005, 1060 (1-2), pp.108-17. ⟨10.1016/j.brainres.2005.08.032⟩
Journal articles istex inserm-00423385v1

Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity

Conrad Fischer , Tess Lamer , Kleinberg Fernandez , Mahmoud Gheblawi , Wang Wang et al.
Journal of Medicinal Chemistry, 2020, 63 (20), pp.12073-12082. ⟨10.1021/acs.jmedchem.0c01395⟩
Journal articles hal-03011719v1

Central Apelin Controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice.

Thibaut Duparc , André Colom , Patrice D. Cani , Nicolas Massaly , Sophie Rastrelli et al.
Antioxidants and Redox Signaling, 2011, 15 (6), pp.1477-96. ⟨10.1089/ars.2010.3454⟩
Journal articles inserm-00617581v1
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Role of angiotensin III in hypertension

Annabelle Reaux-Le Goazigo , Xavier Iturrioz , Céline Fassot , Cédric Claperon , Bernard P. Roques et al.
Current Hypertension Reports, 2005, 7 (2), pp.128-134. ⟨10.1007/s11906-005-0087-z⟩
Journal articles hal-02524845v1
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Activating the apelin receptor with LIT01-196, a metabolically stable apelin analog, reverses AVP-induced antidiuresis and hyponatremia

Adrien Flahault , Pierre-Emmanuel Girault-Sotias , Mathilde Keck , Rodrigo Alvear-Perez , Nadia de Mota et al.
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-020-20560-y⟩
Journal articles hal-03285794v1

Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides

Christelle David , Laurent Bischoff , Hervé Meudal , Catherine Llorens-Cortes , Bernard Pierre Roques et al.
Letters in Peptide Science, 1997, 4 (4/6), pp.411-414. ⟨10.1023/A:1008894115205⟩
Journal articles istex hal-02122127v1

Biased Signaling Favoring Gi over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine

Emilie Ceraudo , Cécile Galanth , Eric Carpentier , Inmaculada Banegas-Font , Anne-Marie Schonegge et al.
Journal of Biological Chemistry, 2014, 289 (35), pp.24599-24610. ⟨10.1074/jbc.M113.541698⟩
Journal articles hal-03631034v1

Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity.

Cédric Claperon , Raphael Rozenfeld , Xavier Iturrioz , Nicolas Inguimbert , Mayumi Okada et al.
Biochemical Journal, 2008, 416 (1), pp.37-46. ⟨10.1042/BJ20080471⟩
Journal articles inserm-00422659v1

Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli.

Michel Azizi , Xavier Iturrioz , Anne Blanchard , Séverine Peyrard , Nadia de Mota et al.
Journal of the American Society of Nephrology, 2008, 19 (5), pp.1015-24. ⟨10.1681/ASN.2007070816⟩
Journal articles inserm-00422689v1

Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli

Michel Azizi , Xavier Iturrioz , Anne Blanchard , Séverine Peyrard , Nadia de Mota et al.
Journal of the American Society of Nephrology, 2008, 19 (5), pp.1015-1024. ⟨10.1681/ASN.2007070816⟩
Journal articles hal-03631046v1

Contribution of molecular modeling and site-directed mutagenesis to the identification of threonine 348 as a residue involved in aminopeptidase a substrate specificity.

Cédric Claperon , Raphael Rozenfeld , Xavier Iturrioz , Nicolas Inguimbert , Mayumi Okada et al.
Journal of Biological Chemistry, 2008
Journal articles inria-00339129v1

Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity.

Cédric Claperon , Inmaculada Banegas-Font , Xavier Iturrioz , Raphael Rozenfeld , Bernard Maigret et al.
Journal of Biological Chemistry, 2009, 284 (16), pp.10618-26. ⟨10.1074/jbc.M806783200⟩
Journal articles inserm-00418798v1

Functional dissociation between apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure

Xavier Iturrioz , Said El Messari , N. de Mota , C. Fassot , Rodrigo Alvear-Perez et al.
Archives des Maladies du Coeur et des Vaisseaux, 2007, 100 (8), pp.704-8. ⟨10.1097/01.hjh.0000298976.36334.9b⟩
Journal articles inserm-00424423v1

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

Nicolas Chartrel , Rodrigo Alvear-Perez , Jérôme Leprince , Xavier Iturrioz , Annabelle Reaux-Le Goazigo et al.
Science, 2007, 315 (5813), pp.766-766. ⟨10.1126/science.1135047⟩
Journal articles inserm-00424430v1
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A snake toxin as a theranostic agent for the type 2 vasopressin receptor

Laura Droctové , Manon Lancien , Vu Long Tran , Michaël Susset , Benoit Jego et al.
Theranostics, 2020
Journal articles hal-03070378v1

Fluorocarbon-peptide conjugates (FPC): new concept to increase the metabolic stability of peptides for therapeutic applications

Sridevi M. Ramanoudjame , Lucie Esteoulle , Adrien Flahault , Cendrine Seguin , Stéphanie Riché et al.
Peptide Science 2018: Proceedings of the 10th International Peptide Symposium / The 55th Japanese Peptide Symposium Shiroh Futaki and Katsumi Matsuzaki (Editors), 2018, Kyoto, Japan. pp.S150-S150
Conference papers hal-02347485v1

Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug

Fabrice Balavoine , Michel Azizi , Damien Bergerot , Nadia de Mota , Remi Patouret et al.
Clinical Pharmacokinetics, 2014, 53 (4), pp.385-395. ⟨10.1007/s40262-013-0125-y⟩
Journal articles hal-03292696v1