Multiple Cross Talk between Angiotensin II, Bradykinin, and Insulin Signaling in the Cortical Thick Ascending Limb of Rat Kidney
Annette Hus-Citharel
,
Nadine Bouby
,
Xavier Iturrioz
,
Catherine Llorens-Cortes
Journal articles
hal-03631040v1
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Tyrosine Kinase and Mitogen-Activated Protein Kinase/Extracellularly Regulated Kinase Differentially Regulate Intracellular Calcium Concentration Responses to Angiotensin II/III and Bradykinin in Rat Cortical Thick Ascending Limb
Annette Hus-Citharel
,
Xavier Iturrioz
,
Pierre Corvol
,
Jeannine Marchetti
,
Catherine Llorens-Cortes
et al.
Journal articles
hal-03631052v1
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Structural insight into the catalytic mechanism and inhibitor binding of aminopeptidase A
Pierre Couvineau
,
Hugo de Almeida
,
Vincent Leroux
,
Bernard Roques
,
Bernard Maigret
et al.
Journal articles
hal-03029058v1
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Contribution of Molecular Modeling and Site-Directed Mutagenesis to the Identification of a New Residue, Glutamate 215, Involved in the Exopeptidase Specificity of Aminopeptidase A
Raphaël Rozenfeld
,
Xavier Iturrioz
,
Mayumi Okada
,
Bernard Maigret
,
Catherine Llorens-Cortes
et al.
Journal articles
istex
hal-03631059v1
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A snake toxin as a theranostic agent for the type 2 vasopressin receptor
Laura Droctové
,
Manon Lancien
,
Vu Long Tran
,
Michaël Susset
,
Benoit Jego
et al.
Journal articles
hal-02960704v1
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LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism
Adrien Flahault
,
Mathilde Keck
,
Pierre-Emmanuel Girault-Sotias
,
Lucie Esteoulle
,
Nadia de Mota
et al.
Journal articles
hal-03322968v1
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A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension
Michel Azizi
,
Pierre-Yves Courand
,
Thierry Denolle
,
Pascal Delsart
,
Valentina Zhygalina
et al.
Journal articles
hal-03149099v1
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Tyrosine kinase and mitogen-activated protein kinase/extracellularly regulated kinase differentially regulate intracellular calcium concentration responses to angiotensin II/III and bradykinin in rat cortical thick ascending limb.
Annette Hus-Citharel
,
Xavier Iturrioz
,
Pierre Corvol
,
Jeannine Marchetti
,
Catherine Llorens-Cortes
et al.
Journal articles
inserm-00423374v1
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Orally Active Aminopeptidase A Inhibitor Prodrugs: Current State and Future Directions
Mathilde Keck
,
Reda Hmazzou
,
Catherine Llorens-Cortes
Journal articles
inserm-02262448v1
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Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity
Cédric Claperon
,
Raphael Rozenfeld
,
Xavier Iturrioz
,
Nicolas Inguimbert
,
Mayumi Okada
et al.
Journal articles
hal-03631043v1
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Brain renin-angiotensin system blockade with orally active aminopeptidase A inhibitor prevents cardiac dysfunction after myocardial infarction in mice
Solène Emmanuelle Boitard
,
Yannick Marc
,
Mathilde Keck
,
Nathalie Mougenot
,
Onnik Agbulut
et al.
Journal articles
hal-02265448v1
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Role of angiotensin III in hypertension
Annabelle Reaux-Le Goazigo
,
Xavier Iturrioz
,
Celine Fassot
,
Cedric Claperon
,
Bernard Roques
et al.
Journal articles
hal-03631055v1
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Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme
Christelle David
,
Laurent Bischoff
,
Hervé Meudal
,
Aurélie Mothé
,
Nadia de Mota
et al.
Journal articles
istex
hal-02122148v1
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Roles of brain angiotensins II and III in thirst and sodium appetite.
Wendy L. Wilson
,
Bernard P. Roques
,
Catherine Llorens-Cortes
,
Robert C. Speth
,
Joseph W. Harding
et al.
Journal articles
istex
inserm-00423385v1
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Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity
Conrad Fischer
,
Tess Lamer
,
Kleinberg Fernandez
,
Mahmoud Gheblawi
,
Wang Wang
et al.
Journal articles
hal-03011719v1
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Central Apelin Controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice.
Thibaut Duparc
,
André Colom
,
Patrice D. Cani
,
Nicolas Massaly
,
Sophie Rastrelli
et al.
Journal articles
inserm-00617581v1
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Role of angiotensin III in hypertension
Annabelle Reaux-Le Goazigo
,
Xavier Iturrioz
,
Céline Fassot
,
Cédric Claperon
,
Bernard P. Roques
et al.
Journal articles
hal-02524845v1
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Activating the apelin receptor with LIT01-196, a metabolically stable apelin analog, reverses AVP-induced antidiuresis and hyponatremia
Adrien Flahault
,
Pierre-Emmanuel Girault-Sotias
,
Mathilde Keck
,
Rodrigo Alvear-Perez
,
Nadia de Mota
et al.
Journal articles
hal-03285794v1
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Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides
Christelle David
,
Laurent Bischoff
,
Hervé Meudal
,
Catherine Llorens-Cortes
,
Bernard Pierre Roques
et al.
Journal articles
istex
hal-02122127v1
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Biased Signaling Favoring Gi over β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine
Emilie Ceraudo
,
Cécile Galanth
,
Eric Carpentier
,
Inmaculada Banegas-Font
,
Anne-Marie Schonegge
et al.
Journal articles
hal-03631034v1
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Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity.
Cédric Claperon
,
Raphael Rozenfeld
,
Xavier Iturrioz
,
Nicolas Inguimbert
,
Mayumi Okada
et al.
Journal articles
inserm-00422659v1
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Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli.
Michel Azizi
,
Xavier Iturrioz
,
Anne Blanchard
,
Séverine Peyrard
,
Nadia de Mota
et al.
Journal articles
inserm-00422689v1
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Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli
Michel Azizi
,
Xavier Iturrioz
,
Anne Blanchard
,
Séverine Peyrard
,
Nadia de Mota
et al.
Journal articles
hal-03631046v1
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Contribution of molecular modeling and site-directed mutagenesis to the identification of threonine 348 as a residue involved in aminopeptidase a substrate specificity.
Cédric Claperon
,
Raphael Rozenfeld
,
Xavier Iturrioz
,
Nicolas Inguimbert
,
Mayumi Okada
et al.
Journal of Biological Chemistry , 2008
Journal articles
inria-00339129v1
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Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity.
Cédric Claperon
,
Inmaculada Banegas-Font
,
Xavier Iturrioz
,
Raphael Rozenfeld
,
Bernard Maigret
et al.
Journal articles
inserm-00418798v1
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Functional dissociation between apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure
Xavier Iturrioz
,
Said El Messari
,
N. de Mota
,
C. Fassot
,
Rodrigo Alvear-Perez
et al.
Journal articles
inserm-00424423v1
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Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".
Nicolas Chartrel
,
Rodrigo Alvear-Perez
,
Jérôme Leprince
,
Xavier Iturrioz
,
Annabelle Reaux-Le Goazigo
et al.
Journal articles
inserm-00424430v1
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A snake toxin as a theranostic agent for the type 2 vasopressin receptor
Laura Droctové
,
Manon Lancien
,
Vu Long Tran
,
Michaël Susset
,
Benoit Jego
et al.
Theranostics , 2020
Journal articles
hal-03070378v1
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Fluorocarbon-peptide conjugates (FPC): new concept to increase the metabolic stability of peptides for therapeutic applications
Sridevi M. Ramanoudjame
,
Lucie Esteoulle
,
Adrien Flahault
,
Cendrine Seguin
,
Stéphanie Riché
et al.
Peptide Science 2018: Proceedings of the 10th International Peptide Symposium / The 55th Japanese Peptide Symposium Shiroh Futaki and Katsumi Matsuzaki (Editors) , 2018, Kyoto, Japan. pp.S150-S150
Conference papers
hal-02347485v1
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Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug
Fabrice Balavoine
,
Michel Azizi
,
Damien Bergerot
,
Nadia de Mota
,
Remi Patouret
et al.
Journal articles
hal-03292696v1
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