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High-throughput screening for extracellular inhibitors of the FLT3 receptor tyrosine kinase reveals chemically diverse and druggable negative allosteric modulators

Romain Hany , Jean-Philippe Leyris , Guillaume Bret , Sylvie Mallié , Chamroeun Sar et al.
ACS Chemical Biology, 2022, 17 (3), pp.709-722. ⟨10.1021/acschembio.2c00048⟩
Journal articles hal-03747971v1

Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity

Anne-Florence Blandin , Aurélie Durand , Marie Litzler , Aurélien Tripp , Eric Guérin et al.
Cancers, 2019, 11 (12), pp.1875. ⟨10.3390/cancers11121875⟩
Journal articles hal-03098718v1
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Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians

Emeline Houël , Flore Nardella , Valérie Jullian , Alexis Valentin , Catherine Vonthron-Sénécheau et al.
Journal of Ethnopharmacology, 2016, 187, pp.241-248. ⟨10.1016/j.jep.2016.04.053⟩
Journal articles hal-01313006v1

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia

Pierre Regenass , Dayana Abboud , Francois Daubeuf , Christine Lehalle , Patrick Gizzi et al.
Journal of Medicinal Chemistry, 2018, 61 (17), pp.7671-7686. ⟨10.1021/ACS.JMEDCHEM.8B00657⟩
Journal articles hal-02366281v1
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Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor

Fabien Hanser , Claire Marsol , Christel Valencia , Pascal Villa , Andrey S Klymchenko et al.
ACS Chemical Biology, 2021, 16 (4), pp.651-660. ⟨10.1021/acschembio.0c00897⟩
Journal articles hal-03437257v1

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor

Christel Valencia , Céline Dujet , Jean-François Margathe , Xavier Iturrioz , Thomas Roux et al.
ChemMedChem, 2017, 12 (12), pp.925-931. ⟨10.1002/cmdc.201700106⟩
Journal articles hal-02153692v1
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LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism

Marie-Céline Frantz , Lucie P. Pellissier , Elsa Pflimlin , Stéphanie Loison , Jorge Gandía et al.
Journal of Medicinal Chemistry, 2018, 61 (19), pp.8670-8692. ⟨10.1021/acs.jmedchem.8b00697⟩
Journal articles hal-02366272v1

Takamalaimë (Psidium acutangulum Mart ex. DC): understanding the use of an antimalarial traditional remedy from French Guiana

Emeline S Houël , Marie Fleury , Valérie Jullian , Catherine Vonthron-Sénécheau , Flore Nardella et al.
Planta Medica, 80 (10), pp.797-797, 2014
Proceedings hal-03278506v1
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Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen.

Nadège Calmels , Hervé Seznec , Pascal Villa , Laurence Reutenauer , Marcel Hibert et al.
BMC Neurology, 2009, 9, pp.46. ⟨10.1186/1471-2377-9-46⟩
Journal articles inserm-00420798v1
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Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

André-Guilhem Calas , Anne-Sophie Hanak , Nina Jaffré , Aurélie Nervo , José Dias et al.
Biomolecules, 2020, 10 (6), pp.858. ⟨10.3390/biom10060858⟩
Journal articles hal-03127255v1
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Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells

Maria Zeniou , Marie Fève , Samir Mameri , Jihu Dong , Christophe Salomé et al.
PLoS ONE, 2015, 10 (8), pp.e0134793. ⟨10.1371/journal.pone.0134793⟩
Journal articles hal-01223842v1
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A strategy to discover decoy chemokine ligands with an anti-inflammatory activity

Dayana Abboud , Francois Daubeuf , Quoc Tuan Do , Valérie Utard , Pascal Villa et al.
Scientific Reports, 2015, 5, pp.14746. ⟨10.1038/srep14746⟩
Journal articles hal-02193983v1

Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: Takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae)

Emeline S Houël , Marie Fleury , Guillaume Odonne , Flore Nardella , Geneviève Bourdy et al.
Journal of Ethnopharmacology, 2015, 166, pp.279-285. ⟨10.1016/j.jep.2015.03.015⟩
Journal articles hal-01152706v1

Daunorubicin reduces MBNL1 titration by expanded CUG repeat RNA and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

M. Chakraborty , Chantal Sellier , Michel Ney , Pascal Villa , Nicolas Charlet-Berguerand et al.
Disease Models & Mechanisms, 2018, ⟨10.1242/dmm.032557⟩
Journal articles hal-03339524v1
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WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3 cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling

Wanyin Chen , Leonel Nguekeu Zebaze , Jihu Dong , Laëtitia Chezeau , Perrine Inquimbert et al.
Oncotarget, 2018, 9 (43), ⟨10.18632/oncotarget.25509⟩
Journal articles hal-02349611v1
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Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia

Pierre Regenass , Dayana Abboud , François Daubeuf , Christine Lehalle , Patrick Gizzi et al.
Journal of Medicinal Chemistry, 2018, 61 (17), pp.7671-7686. ⟨10.1021/acs.jmedchem.8b00657⟩
Journal articles hal-03563473v1
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Anti-Inflammatory, Antioxidant, and Wound-Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-Les-Bains, France: A Multi-Approach Study

Justine Demay , Sébastien Halary , Adeline Knittel-Obrecht , Pascal Villa , Charlotte Duval et al.
Biomolecules, 2021, 11 (1), pp.28. ⟨10.3390/biom11010028⟩
Journal articles hal-03091030v1
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Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model

Martine Schmitt , Maud Bollenbach , Simona Nemska; Patrick Wagner , Guillaume Camelin , Francois Daubeuf et al.
Molecules, In press
Journal articles hal-03113242v1

Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation

Maud Bollenbach , Eric Salvat , Francois Daubeuf , Patrick Wagner , Ipek Yalcin et al.
European Journal of Medicinal Chemistry, 2018, 147, pp.163-182. ⟨10.1016/j.ejmech.2018.01.049⟩
Journal articles hal-02323729v1
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Treating leishmaniasis in Amazonia, part 2: Multi-target evaluation of widely used plants to understand medicinal practices

Emeline S Houël , Marine Ginouves , Nadine Azas , Eliane Bourreau , Véronique Eparvier et al.
Journal of Ethnopharmacology, 2022, 289, pp.115054. ⟨10.1016/j.jep.2022.115054⟩
Journal articles hal-03678995v1
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Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model

Maud Bollenbach , Simona Nemska , Patrick Wagner , Guillaume Camelin , François Daubeuf et al.
Molecules, 2021, 26 (2), pp.391. ⟨10.3390/molecules26020391⟩
Journal articles hal-03266504v1