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The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei

Kota Mochizuki , Daniel Ken Inaoka , Muriel Mazet , Tomoo Shiba , Keisuke Fukuda et al.
Biochimica biophysica acta (BBA) - Bioenergetics, 2020, 1861 (11), pp.148283. ⟨10.1016/j.bbabio.2020.148283⟩
Journal articles hal-03009591v1
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Gluconeogenesis is essential for trypanosome development in the tsetse fly vector

Marion Wargnies , Eloise Bertiaux , Edern Cahoreau , Nicole Ziebart , Aline Crouzols et al.
PLoS Pathogens, 2018, 14 (12), pp.e1007502. ⟨10.1371/journal.ppat.1007502⟩
Journal articles pasteur-01963538v1
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Efficient flavinylation of glycosomal fumarate reductase by its own ApbE domain in Trypanosoma brucei

Robin Schenk , Sabine Bachmaier , Frédéric Bringaud , Michael Boshart
FEBS Journal, 2021, ⟨10.1111/febs.15812⟩
Journal articles hal-03216697v1
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ATP Synthesis-coupled and -uncoupled Acetate Production from Acetyl-CoA by Mitochondrial Acetate: Succinate CoA-transferase and Acetyl-CoA Thioesterase in Trypanosoma

Yoann Millerioux , Pauline Morand , Marc Biran , Muriel Mazet , Patrick Moreau et al.
Journal of Biological Chemistry, 2012, 287 (21), pp.17186 - 17197. ⟨10.1074/jbc.M112.355404⟩
Journal articles hal-01268341v1
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Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline

Oriana Villafraz , Marc Biran , Erika Pineda , Nicolas Plazolles , Edern Cahoreau et al.
PLoS Pathogens, 2021, 17 (3), pp.e1009204. ⟨10.1371/journal.ppat.1009204⟩
Journal articles hal-03366686v1
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Triacylglycerol storage in lipid droplets in procyclic Trypanosoma brucei

Stefan Allmann , Muriel Mazet , Nicole Ziebart , Guillaume Bouyssou , Laetitia Fouillen et al.
PLoS ONE, 2014, 9 (12), pp.1-22. ⟨10.1371/journal.pone.0114628⟩
Journal articles hal-02633640v1
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TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

Sanu Shameer , Flora J. Logan-Klumpler , Florence Vinson , Ludovic Cottret , Benjamin Merlet et al.
Nucleic Acids Research, 2015, 43 (D1), pp.D637 - D644. ⟨10.1093/nar/gku944⟩
Journal articles hal-02631222v1

Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes.

Loïc Rivière , Patrick Moreau , Stefan Allmann , Matthias Hahn , Marc Biran et al.
Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (31), pp.12694-9. ⟨10.1073/pnas.0903355106⟩
Journal articles hal-00426334v1
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Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase

Marion Wargnies , Nicolas Plazolles , Robin Schenk , Oriana Villafraz , Jean-William Dupuy et al.
Journal of Biological Chemistry, 2021, 296, pp.100548. ⟨10.1016/j.jbc.2021.100548⟩
Journal articles hal-03216701v1