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Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors

Romain Daillère , Bertrand Routy , Anne-Gaëlle Goubet , Alexandria Cogdill , Gladys Ferrere et al.
OncoImmunology, 2020, 9 (1), ⟨10.1080/2162402x.2020.1794423⟩
Journal articles hal-03681841v1

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Bertrand Routy , Emmanuelle Le Chatelier , Lisa Derosa , Connie Duong , Maryam Tidjani Alou et al.
Science, 2018, 359 (6371), pp.91-97. ⟨10.1126/science.aan3706⟩
Journal articles hal-02126484v1
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Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Gladys Ferrere , Maryam Tidjani Alou , Peng Liu , Anne-Gaëlle Goubet , Marine Fidelle et al.
JCI Insight, 2021, 6 (2), ⟨10.1172/jci⟩
Journal articles hal-03169306v1

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

Nicolas Jacquelot , Takahiro Yamazaki , Maria Roberti , Connie Duong , Miles Andrews et al.
Cell Research, 2019, 29 (10), pp.846-861. ⟨10.1038/s41422-019-0224-x⟩
Journal articles hal-02461559v1

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Satoru Yonekura , Safae Terrisse , Carolina Alves Costa Silva , Antoine Lafarge , Valerio Iebba et al.
Cancer Discovery, 2022, 12 (4), pp.1128-1151. ⟨10.1158/2159-8290.CD-21-0999⟩
Journal articles hal-03805638v1
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Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis

Madeleine Spatz , Dragos Ciocan , Gregory Merlen , Dominique Rainteau , Lydie Humbert et al.
JHEP Reports Innovation in Hepatology, 2021, 3 (2), pp.100230. ⟨10.1016/j.jhepr.2021.100230⟩
Journal articles hal-03163159v1

The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals

Jean-Eudes Fahrner , Imran Lahmar , Anne-Gaëlle Goubet , Yacine Haddad , Agathe Carrier et al.
Cancer Discovery, 2022, 12 (4), pp.958-983. ⟨10.1158/2159-8290.CD-21-1441⟩
Journal articles hal-03678977v1
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Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

Anne-Gaëlle Goubet , Agathe Dubuisson , Arthur Geraud , François-Xavier Danlos , Safae Terrisse et al.
Cell Death and Differentiation, 2021, ⟨10.1038/s41418-021-00817-9⟩
Journal articles hal-03333920v1

Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice

Gladys Ferrere , Laura Wrzosek , Frédéric Cailleux , Williams Turpin , Virginie Puchois et al.
Journal of Hepatology, 2017, 66 (4), pp.682-684. ⟨10.1016/j.jhep.2016.11.008⟩
Journal articles hal-01608470v1

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Satoru Yonekura , Safae Terrisse , Carolina Alves Costa Silva , Antoine Lafarge , Valerio Iebba et al.
Cancer Discovery, 2022, 12 (4), pp.1128-1151. ⟨10.1158/2159-8290.CD-21-0999⟩
Journal articles hal-03642500v1
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Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Miles Andrews , Connie Duong , Vancheswaran Gopalakrishnan , Valerio Iebba , Wei-Shen Chen et al.
Nature Medicine, 2021, 27 (8), pp.1432-1441. ⟨10.1038/s41591-021-01406-6⟩
Journal articles hal-03333724v1
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Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Aurélie Fluckiger , Romain Daillere , Mohamed Sassi , Barbara S Sixt , Peng Liu et al.
Science, 2020, 369 (6506), pp.936-942. ⟨10.1126/science.aax0701⟩
Journal articles inserm-02923397v1
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Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

Pushpa Hegde , Emmanuel Weiss , Valérie Paradis , Jinghong Wan , Morgane Mabire et al.
Nature Communications, 2018, 9 (1), pp.2146. ⟨10.1038/s41467-018-04450-y⟩
Journal articles inserm-02339519v1
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Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Maria Paula Roberti , Satoru Yonekura , Connie P. M. Duong , Marion Picard , Gladys Ferrere et al.
Nature Medicine, 2020, 26 (6), p. 919-931. ⟨10.1038/s41591-020-0882-8⟩
Journal articles hal-03313676v1

Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors

Romain Daillère , Bertrand Routy , Anne-Gaëlle Goubet , Alexandria Cogdill , Gladys Ferrere et al.
OncoImmunology, 2020, 9 (1), ⟨10.1080/2162402x.2020.1794423⟩
Journal articles hal-03681591v1
Image document

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

Laura Wrzosek , Dragos Ciocan , Cindy Hugot , Madeleine Spatz , Margot Dupeux et al.
Gut, 2021, 70 (7), pp.1299-1308. ⟨10.1136/gutjnl-2020-321565⟩
Journal articles hal-03329872v1