Search - Archive ouverte HAL Access content directly

Filter your results

73 Results
authIdHal_s : isabelle-krimm

NMR tool for the characterization of protein-fragment complexes

Olivier Cala , Clémentine Aguirre , Tim Ten Brink , Isabelle Krimm
GERM XXV - Conférence du Groupe Français d'Etude de Résonance Magnétique, Jun 2014, Biarritz, France
Conference papers hal-01018840v1

INPHARMA-based identification of ligand binding site in fragment-based drug design

Isabelle Krimm
MedChemComm, 2012, 3 (5), pp.605-610. ⟨10.1039/c2md20035j⟩
Journal articles hal-00819132v1

NMR-Based Characterization of Protein-Fragment Complexes

Isabelle Krimm
Discovery Chemistry Congress, Mar 2013, Munich, Germany
Conference papers hal-00819152v1

Tackling the Interaction of the Multidomain Protein STAM2 with Ubiquitin and Diubiquitin Chains by NMR. Cooperativity or not, that is the Question !

Florence Guillière , Jean-Marc Lancelin , Isabelle Krimm , Olivier Walker , Anja Lange et al.
XXVth International Conference on Magnetic Resonance in Biological Systems (ICMRBS), Aug 2012, Lyon, France
Conference papers hal-00958296v1

Performance of Protein–Ligand Docking with Simulated Chemical Shift Perturbations

Tim Ten Brink , Clémentine Aguirre , Thomas E. Exner , Isabelle Krimm
Journal of Chemical Information and Modeling, 2015, 55 (2), pp.275-283. ⟨10.1021/ci500446s⟩
Journal articles hal-01087991v1

Fragment Linking Strategies for Structure-Based Drug Design

Alexandre Bancet , Claire Raingeval , Thierry Lomberget , Marc Le Borgne , Jean-François Guichou et al.
Journal of Medicinal Chemistry, 2020, 63 (20), pp.11420-11435. ⟨10.1021/acs.jmedchem.0c00242⟩
Journal articles hal-03045139v1

NMR for Fragment-Based Drug Design

Olivier Cala , Isabelle Krimm
27th International Conference on Magnetic Resonance in Biological Systems - ICMRBS2016, Aug 2016, Kyoto, Japan
Conference poster hal-01397732v1
Image document

Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors

Lucile Lecas , Lucie Hartmann , Lydia Caro , Sarah Mohamed-Bouteben , Claire Raingeval et al.
Analytica Chimica Acta, 2020, 1113, pp.26-35. ⟨10.1016/j.aca.2020.03.062⟩
Journal articles hal-03045118v1
Image document

Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5

Clémentine Aguirre , Tim Ten Brink , Jean François Guichou , Olivier Cala , Isabelle Krimm et al.
PLoS ONE, 2014, 9 (7), pp.e102300. ⟨10.1371/journal.pone.0102300⟩
Journal articles hal-01067905v1

Comparaison du mode de liaison de fragments analogues par RMN quantitative dans le contexte du Drug Design

Clémentine Aguirre , Tim Ten Brink , Olivier Cala , Isabelle Krimm
15ème Journée RMN Rhône Alpes, Jun 2014, Grenoble, France
Conference papers hal-01018842v1

NMR applications in FBDD regarding fragment binding mode and framgent-induced protein conformational change

Isabelle Krimm
Zing Conference - Fragment-Based Drug Discovery, Jul 2014, Punta Cana, Dominican Republic
Conference papers hal-00955950v1

Les molécules fragments : un outil puissant en chimie biologique

Isabelle Krimm
14èmes REncontres en Chimie Organique Biologique (RECOB'14), Mar 2012, Aussois, France
Conference papers hal-00819219v1

Protein–ligand structure guided by backbone and side-chain proton chemical shift perturbations

Clémentine Aguirre , Olivier Cala , Tim Ten Brink , Jean François Guichou , Isabelle Krimm et al.
Journal of Biomolecular NMR, 2014, 60 (2-3), pp.147-156. ⟨10.1007/s10858-014-9864-9⟩
Journal articles hal-01088012v1

Fragment-based screening: a promising avenue for drug design

Isabelle Krimm
médecine/sciences, 2015, 31 (2), pp.197-202. ⟨10.1051/medsci/20153102017⟩
Journal articles hal-01187367v1

HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories.

Jaime Prilusky , Eric Oeuillet , Nathalie Ulryck , Anne Pajon , Julie Bernauer et al.
Acta crystallographica Section D : Structural biology [1993-..], 2005, 61 (Pt 6), pp.671-678. ⟨10.1107/S0907444905001290⟩
Journal articles istex inria-00431702v1

Etude de complexes protéine-ligand par RMN quantitative dans le contexte du Drug Design

Clémentine Aguirre , Florence Guillière , Dany Davesne , Isabelle Krimm
Journée de Printemps de la Société Chimique de France, Jun 2012, Lyon, France
Conference papers hal-00819230v1
Image document

A Deep Dive into VDAC1 Conformational Diversity Using All-Atom Simulations Provides New Insights into the Structural Origin of the Closed States

Jordane Preto , Hubert Gorny , Isabelle Krimm
International Journal of Molecular Sciences, 2022, 23 (3), pp.1175. ⟨10.3390/ijms23031175⟩
Journal articles hal-03856956v1
Image document

Biophysical Dissection of Isolated GPCRs: The Adenosine A2A Receptor under the Bistouries

Jean-Louis Banères , Thomas Botzanowski , Jean A Boutin , Barbara Calamini , Jérôme Castel et al.
Receptors and Channels, 2023, 2 (1), pp.47-92. ⟨10.3390/receptors2010004⟩
Journal articles hal-04003751v1

Probing ligand binding mode by NMR in Fragment-Based Drug design

Clémentine Aguirre , Florence Guillière , Dany Davesne , Isabelle Krimm
XXVth International Conference on Magnetic Resonance in Biological Systems (ICMRBS), Aug 2012, Lyon, France
Conference papers hal-00819174v1

Probing hot spots on protein-protein interfaces using fragment-based drug design

Sarah Barelier , Isabelle Krimm
EMBO Workshop "Advances in Protein-Protein - Interaction Analysis & Modulation", Jun 2012, Roscoff, France
Conference papers hal-00819202v1

Etude de complexes protéine-ligand par RMN quantitative dans le contexte du Drug Design

Clémentine Aguirre , Isabelle Krimm
GTBio 2012, Apr 2012, Montpellier, France
Conference papers hal-00819210v1

Analyse des complexes protéine-ligand par RMN dans le cadre de la conception de médicaments

Clémentine Aguirre , Tim Ten Brink , Isabelle Krimm
Journée Rhône-Alpes des Biomolécules (JRAB 2013), Jun 2013, Lyon, France
Conference papers hal-00873777v1

Applications of NMR for fragment-based drug design

Isabelle Krimm , Olivier Cala
Journée scientifique de la Fédération de Recherche FR2708 (COA UMR 7311 et CBM UPR4301), Jun 2014, Orléans, France
Conference papers hal-01067919v1
Image document

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

Claire Raingeval , Olivier Cala , Béatrice Brion , Marc Le Borgne , Roderick Eliot Hubbard et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.1218-1225. ⟨10.1080/14756366.2019.1636235⟩
Journal articles hal-02188259v1

Evolution et nouvelles tendances dans les sciences analytiques pour le domaine pharmaceutique

Isabelle Krimm
Congrès Africain et Francophone sur les Sciences Analytiques et Applications (CAFSAA) , Nov 2017, Hammamet, Tunisie
Conference papers hal-01864864v1

NMR structures of thioredoxin m from the green alga Chlamydomonas reinhardtii

Jean‐marc Lancelin , Laure Guilhaudis , Isabelle Krimm , Martin Blackledge , Dominique Marion et al.
Proteins: Structure, Function, and Genetics, 2000, 41 (3), pp.334-349. ⟨10.1002/1097-0134(20001115)41:3<334::aid-prot60>3.3.co;2-d⟩
Journal articles hal-02352003v1

A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles

Jens Pilger , Adam Mazur , Peter Monecke , Herman Schreuder , Bettina Elshorst et al.
Angewandte Chemie, 2015, 54 (22), pp.6511-6515. ⟨10.1002/anie.201500671⟩
Journal articles istex hal-01165216v1

NMR approaches in fragment-based drug design

Isabelle Krimm
ChemBioInteract "Conference on Drug Discovery & Drug Design: ChemBio Interactions", Oct 2013, Lyon, France
Conference papers hal-00955939v1
Image document

BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR

Clémentine Aguirre , Tim Ten Brink , Olivier Walker , Florence Guillière , D. Davesne et al.
PLoS ONE, 2013, 8, pp.e64400. ⟨10.1371/journal.pone.0064400⟩
Journal articles in2p3-00839023v1

The Dynamics of Copper Uptake in Human Cu,Zn-Superoxide Dismutase: a Solid-State NMR Study

Claire Raingeval , Olivier Cala , Béatrice Brion , Isabelle Krimm
XXIXème congrès du GERM, Groupement d'études de résonance magnétique, May 2017, Aussois, France
Conference papers hal-01865374v1