Viral amyloids: New opportunities for antiviral therapeutic strategies - Architecture et Fonction des Macromolécules Biologiques Access content directly
Journal Articles (Review Article) Current Opinion in Structural Biology Year : 2023

Viral amyloids: New opportunities for antiviral therapeutic strategies


Amyloidoses are an array of diseases associated with the aggregation of proteins into fibrils. While it was previously thought that amyloid fibril-forming proteins are exclusively host-cell encoded, recent studies have revealed that pathogenic viruses can form amyloid-like fibrils too. Intriguingly, viral amyloids are often composed of virulence factors, known for their contribution to cell death and disease progression. In this review, we survey the literature about viral proteins capable of forming amyloid-like fibrils. The molecular and cellular mechanisms underlying the formation of viral amyloid-like aggregates are explored. In addition, we discuss the functional implications for viral amplification and the complex interplay between viral amyloids, biological functions, virulence, and virus-induced pathologies.
Fichier principal
Vignette du fichier
Revised_Manuscript_Gondelaud_with_Figures_and_Table clean.pdf (1.86 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-04520746 , version 1 (25-03-2024)



Frank Gondelaud, Pierre-Yves Lozach, Sonia Longhi. Viral amyloids: New opportunities for antiviral therapeutic strategies. Current Opinion in Structural Biology, 2023, 83, pp.102706. ⟨10.1016/⟩. ⟨hal-04520746⟩
43 View
9 Download



Gmail Mastodon Facebook X LinkedIn More