In Situ Growth of Silver Nanoparticles into Reducing-End Carbohydrate-Based Supramolecular Hydrogels for Antimicrobial Applications
Production in-situ de nanoparticules d'argent dans un hydrogel supramoléculaire composé de sucres réducteurs pour des applications antibactériennes
Résumé
Hydrogels with antibacterial activities have the potential for many biomedical applications, such as wound healing, because the maintaining of the moist environment and the prevent of infections. In this work, an ultrasound-induced supramolecular hydrogel consisting of easily accessible reducing-end free glucosaminylbarbiturate-based hydrogelators that serve for in situ fabrication of silver nanoparticles (AgNPs), excluding the addition of any external reducing or stabilizing agents, has been developed. The innovative synthetic approach relied on the use of N,N'-disubstituted barbituric acid derivatives as a versatile chemical platform that site-selectively reacted with amino function of glucosamine. A series of glucosaminylbarbiturate were synthesized and we identified one carbohydrate-based hydrogelator that produced a thixotropic 2 supramolecular hydrogel after ultrasound-mediated breaking of an intralocked hydrogen bond.
AgNPs@hydrogel were prepared through in situ reduction of silver ions mediated by reducing properties of carbohydrates. The AgNPs@hydrogel composite revealed good antimicrobial properties towards both Gram-positive and Gram-negative bacteria. These findings contribute to the development of carbohydrate-based supramolecular hydrogels and make them promising efficient and safe soft materials for antimicrobial therapy.
Mots clés
Carbohydrate chemistry chemoselective reactions supramolecular hydrogels silver nanoparticles antibacterial
Carbohydrate chemistry
chemoselective reactions
supramolecular hydrogels
silver nanoparticles
antibacterial
Carbohydrate chemistry chemoselective reactions supramolecular hydrogels silver nanoparticles antibacterial