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Journal Articles Biomolecules Year : 2022

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

1 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
2 PANTHER - Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices
3 METSY - Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques
4 LBMC UMR 5239 - Laboratoire de biologie et modélisation de la cellule
5 IGMM - Institut de Génétique Moléculaire de Montpellier
6 LilNCog - Lille Neurosciences & Cognition - U 1172
7 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
8 T3S - UMR_S 1124 - Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire
9 HCL - Hospices Civils de Lyon
10 LGBC - Laboratoire de génétique et biologie cellulaire
11 EPHE - École Pratique des Hautes Études
12 CRCI2NA - Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers
13 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
14 CRIBL - Contrôle de la Réponse Immune B et des Lymphoproliférations
15 Cellules Souches et Développement / Stem Cells and Development
16 IBGC - Institut de biochimie et génétique cellulaires
17 CHU Pitié-Salpêtrière [AP-HP]
18 IUF - Institut universitaire de France
19 HIPI (UMR_S_976 / U976) - Immunologie humaine, physiopathologie & immunothérapie
20 C3M - Centre méditerranéen de médecine moléculaire
21 UGENT - Universiteit Gent = Ghent University
22 PhLAM - Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523
23 CBI - Centre de Biologie Intégrative
24 ACTION - Actions for OnCogenesis understanding and Target Identification in ONcology
Gabriel Ichim
David Devos
Guido Kroemer
Santos Susin
Magali Suzanne

Abstract

Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although many aspects of regulated cell death still remain to be elucidated in specific cell subtypes and disease conditions, many predicted that research into cell death was inexorably reaching a plateau. However, this was not the case since the last decade saw a multitude of cell death modalities being described, while harnessing their therapeutic potential reached clinical use in certain cases. In line with keeping research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN). The research conducted by FCDRN is at the leading edge of emerging topics such as non-apoptotic functions of apoptotic effectors, paracrine effects of cell death, novel canonical and non-canonical mechanisms to induce apoptosis in cell death-resistant cancer cells or regulated forms of necrosis and the associated immunogenic response. Collectively, these various lines of research all emerged from the study of apoptosis and in the next few years will increase the mechanistic knowledge into regulated cell death and how to harness it for therapy.
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hal-03711790 , version 1 (01-07-2022)

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Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, et al.. Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network. Biomolecules, 2022, 12 (7), pp.901. ⟨10.3390/biom12070901⟩. ⟨hal-03711790⟩
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