The current paradigm and challenges ahead for the dormancy of disseminated tumor cells
Résumé
Disseminated tumor cells (DTCs) are known to enter a state of dormancy, which is achieved via growth arrest of DTCs and/or a form of population equilibrium state, strongly influenced by the organ microenvironment. During this time, expansion of residual disseminated cancer is paused and DTCs survive to fuel relapse, sometimes decades later. This notion has opened a new window of opportunity to intervene and prevent relapse. Here we review recent data that have further augmented our understanding of cancer dormancy and discuss how this is leading to new strategies to monitor and target dormant cancer.
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers produits par l'(les) auteur(s)