The current paradigm and challenges ahead for the dormancy of disseminated tumor cells - Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard) Accéder directement au contenu
Article Dans Une Revue Nature Cancer Année : 2020

The current paradigm and challenges ahead for the dormancy of disseminated tumor cells

Résumé

Disseminated tumor cells (DTCs) are known to enter a state of dormancy, which is achieved via growth arrest of DTCs and/or a form of population equilibrium state, strongly influenced by the organ microenvironment. During this time, expansion of residual disseminated cancer is paused and DTCs survive to fuel relapse, sometimes decades later. This notion has opened a new window of opportunity to intervene and prevent relapse. Here we review recent data that have further augmented our understanding of cancer dormancy and discuss how this is leading to new strategies to monitor and target dormant cancer.
Fichier principal
Vignette du fichier
Risson et al Nat Cancer 2020.pdf (3.81 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03418499 , version 1 (12-11-2021)

Identifiants

Citer

Emma Risson, Ana Rita Nobre, Veronique Maguer-Satta, Julio A. Aguirre-Ghiso. The current paradigm and challenges ahead for the dormancy of disseminated tumor cells. Nature Cancer, 2020, ⟨10.1038/s43018-020-0088-5⟩. ⟨hal-03418499⟩
48 Consultations
45 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More