Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment - Département de Chimie Moléculaire Accéder directement au contenu
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Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment

Résumé

Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation. By combining different redox-economical catalytic stereoselective transformations, the key polyketide fragment could be rapidly prepared. Followed by a site-selective protection of the diol, this strategy enables the preparation of the apratoxin A fragment in only six steps, representing the shortest route to this polyketide.

Domaines

Chimie organique

Dates et versions

hal-03955423 , version 1 (25-01-2023)

Licence

Domaine public

Identifiants

  • HAL Id : hal-03955423 , version 1

Citer

Na Shao, Jean Rodriguez, Adrien Quintard. Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment. France. 2022. ⟨hal-03955423⟩
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