Pd‐Catalyzed Coupling of Bromo‐N‐(β‐glucopyranosyl)quinolin‐2‐ones with Amides: Synthesis of N‐glucosyl‐6BrCaQ Conjugates with Potent Anticancer Activity
Résumé
A series of N ‐glycosyl‐ 6BrCaQ conjugates was synthesized through a Pd‐catalyzed cross‐coupling reaction between brominated N ‐glycosyl quinolin‐2‐one derivatives and various nitrogen nucleophiles. Antiproliferative assays revealed that this new series of analogues represents a promising class of antitumor compounds as illustrated by the high biological activity observed for several derivatives towards different cancer cell lines compared to the non‐glycosylated congeners.
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