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Article Dans Une Revue Journal of the Royal Statistical Society: Series C Applied Statistics Année : 2024

A two-sample tree-based test for hierarchically organized genomic signals

Résumé

This article addresses a common type of data encountered in genomic studies, where a signal along a linear chromosome exhibits a hierarchical organization. We propose a novel framework to assess the significance of dissimilarities between two sets of genomic matrices obtained from distinct biological conditions. Our approach relies on a data representation based on trees. It utilizes tree distances and an aggregation procedure for tests performed at the level of leaf pairs. Numerical experiments demonstrate its statistical validity and its superior accuracy and power compared to alternatives. The method’s effectiveness is illustrated using real-world data from GWAS and Hi-C data.
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hal-04516167 , version 1 (22-03-2024)

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Pierre Neuvial, Nathanaël Randriamihamison, Marie Chavent, Sylvain Foissac, Nathalie Vialaneix. A two-sample tree-based test for hierarchically organized genomic signals. Journal of the Royal Statistical Society: Series C Applied Statistics, 2024, pp.qlae011. ⟨10.1093/jrsssc/qlae011⟩. ⟨hal-04516167⟩
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