Interleukin-1 receptor deficiency in brains from NZB and (NZB/NZW)F1 autoimmune mice. - BIG - Chimie et Biologie des Métaux (CBM) Accéder directement au contenu
Article Dans Une Revue Journal of Neuroimmunology Année : 1994

Interleukin-1 receptor deficiency in brains from NZB and (NZB/NZW)F1 autoimmune mice.

M. J. Tehrani
  • Fonction : Auteur
Y. Hu
  • Fonction : Auteur
F. Haour
  • Fonction : Auteur
G. Wick
  • Fonction : Auteur

Résumé

Interleukin-1 receptors (IL-1R) are expressed in the brain and the anterior pituitary of normal mice (C3H/He, Swiss), and appear to be involved in the neuroendocrine control of the immune response. Here we have studied the IL-1R density in the brain and the pituitary from several strains of autoimmune mice (NZB, (NZB/NZW)F1, MRL/MP-lpr), using quantitative autoradiography with recombinant human [125I]IL-1 alpha as a ligand. IL-1R was similar in the brain of C3H/He, Swiss and NZW (controls) and MRL/MP-lpr mice. In NZB mice a profound deficit (10% of control mice) in IL-1R was observed exclusively in the dentate gyrus. In (NZB/NZW)F1 the deficit was about 50%. These observations were independent of sex and age. Pituitary receptors were not affected in all the strains except NZW (30% increase). Competition experiments demonstrated that the affinity of IL-1R was not modified in dentate gyrus of (NZB/NZW)F1 and NZW mice. Thus, the number of IL-1R was the only parameter affected. This deficit was not reversed by corticosterone treatment (0.2 mg/20 g body weight, i.p.) and was poorly modified by lipopolysaccharide treatment (0.1 mg/20 g body weight, i.p.) compared to C3H/He mice. In conclusion, this central IL-1R deficit is unlikely to be the consequence of occupancy by abnormal synthesis of brain IL-1. This abnormality is tissue-specific with hereditary autosomal transmission. The role of central IL-1R in neuroimmunoendocrine interactions and in autoimmunity remains to be clarified.

Domaines

Neurobiologie
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Dates et versions

hal-00405269 , version 1 (20-07-2009)

Identifiants

  • HAL Id : hal-00405269 , version 1
  • PUBMED : 8051301

Citer

M. J. Tehrani, Y. Hu, C. Marquette, H. Dietrich, F. Haour, et al.. Interleukin-1 receptor deficiency in brains from NZB and (NZB/NZW)F1 autoimmune mice.. Journal of Neuroimmunology, 1994, 53 (1), pp.91-9. ⟨hal-00405269⟩
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