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Welcome to the Collection

of LBPC-PM

The Laboratory of Physical and Chemical Biology of Membrane Proteins (UMR7099) brings together biologists, physicists and chemists in one location and develops interdisciplinary approaches to understand the function, dynamics and atomic structure of complex membrane systems.

We study the structure and dynamics of membrane barriers that are responsible for many fundamental processes in life: energy conversion from sunlight, substrate oxidation in mitochondria, cell signaling, uptake of vital nutrients, and release of toxic molecules by bacteria. Our fundamental research helps

i) to understand many human diseases: obesity, cancers, neurological and inflammatory diseases and

ii) to build tools to fight bacterial infections (antibiotic resistance, vaccines).

Research within the laboratory is organized in four main themes.

Energy coupling & supramolecular organization of respiratory chain complexes

Molecular pathway of GPGRs

Transport& membrane dynamics
in bacteria

Molecular synthesis of Amphipols and ligands
& biophysical approaches

DOCUMENTS WITH COMPLETE TEXT

52

 

REFEBIBLIOGRAPHIC REFERENCES

87

 

Open Access

67 %

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SHERPA ROMEO

 

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KEYWORDS

Chemistry Chemical biology Analytical modeling FRAP Cell envelope Corynebacterium glutamicum Integral membrane protein complexes Epidemiology Inner membrane Fourier Transform Infrared Lipids Circular Dichroism Bilayer Cryo-EM of membranes disordered by NS4B Cell markers Electron transfer Heme Chemotherapy resistance drug efflux GPCR Density map Phospholipids Amphipol Hedgehogh signal Bacterial nutrient transporter Detergents Endothelial cells Cell-wall Membrane protein reconstitution Phospholipid Detergent SMA co-polymers Amphipol-stabilized integral membrane protein In-cell NMR CryoEM HasR Glycosylation Immunity ATPase activity HCV-NS4B induced membrane disorder Haem Human ABC ATP-binding cassette Blood proteins Flow cytometry Chlamydia muridarum Hydration Colicin Bacteria BBB G protein-coupled receptors Hedgehog signal intrinsically disordered protein small-angle X-ray scattering Membrane proteins In vitro synthesis Endonuclease Dimyristoylphosphatidylcholine Dynamic filters G glycoprotein from rabies virus Corynebacteriales Fluoroquinolone FLIM Hedgehog signal Gram-positive and Gram-negative bacteria Small-angle X-ray scattering Fluorescence Surfactants Cryo-electron microscopy Amphipols Bilayers Solid-state NMR Membrane protein DNA-binding protein Action mechanism DDM Intrinsically disordered protein Cerebrovascular function Cardiolipin Bacteriocin A8 35 CryoEM of membranes fused by NS4B peptide Arabinogalactan F1Fo-ATPase Gramicidin E coli DNA gyrase A8-35 formulation study Hème ci Integral membrane proteins Fungal infections Bacillus subtilis Integrative approach Concussion Extraction In vivo NMR Electron microscopy Interactions Diffusion Mycobacterium Iron Escherichia coli Biochemistry

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