index - Archive ouverte HAL Access content directly


Welcome to the Collection


The Laboratory of Physical and Chemical Biology of Membrane Proteins (UMR7099) brings together biologists, physicists and chemists in one location and develops interdisciplinary approaches to understand the function, dynamics and atomic structure of complex membrane systems.

We study the structure and dynamics of membrane barriers that are responsible for many fundamental processes in life: energy conversion from sunlight, substrate oxidation in mitochondria, cell signaling, uptake of vital nutrients, and release of toxic molecules by bacteria. Our fundamental research helps

i) to understand many human diseases: obesity, cancers, neurological and inflammatory diseases and

ii) to build tools to fight bacterial infections (antibiotic resistance, vaccines).

Research within the laboratory is organized in four main themes.

Energy coupling & supramolecular organization of respiratory chain complexes

Molecular pathway of GPGRs

Transport& membrane dynamics
in bacteria

Molecular synthesis of Amphipols and ligands
& biophysical approaches







Open Access

69 %

Change in deposits

Chargement de la page






Fluoroquinolone CryoEM Surfactants FRAP Detergent F1Fo-ATPase Phospholipids Haem SMA co-polymers Endonuclease Phospholipid Endothelial cells Cell markers Lipoproteins Detergents HasR Chemical biology G protein-coupled receptors Solid-state NMR Hedgehogh signal DNA gyrase Biochemistry Hedgehog signal Intrinsically disordered protein Extraction Cryo-electron microscopy HCV-NS4B induced membrane disorder Fluorescence Chemotherapy resistance drug efflux Integrative approach Blood proteins In vivo NMR Analytical modeling Inner membrane Small-angle X-ray scattering Labelling Escherichia coli Human Amphipols Hème ci Heme Glycosylation Corynebacteriales Diffusion Gram-positive and Gram-negative bacteria G glycoprotein from rabies virus Amphipol-stabilized integral membrane protein Membrane proteins Bilayer Cryo-EM of membranes disordered by NS4B Cardiolipin Lipids Bilayers Flow cytometry BBB ABC ATP-binding cassette Action mechanism LepB Corynebacterium glutamicum Gramicidin GPCR Lipid biosynthesis Colicin In-cell NMR Dynamic filters A8 35 Chlamydia muridarum Membrane protein reconstitution Membrane protein Bacteria CryoEM of membranes fused by NS4B peptide Circular Dichroism Lipid Bilayers Amphipol A8-35 formulation study FLIM Hydration Integral membrane proteins Electron microscopy DNA-binding protein Cell envelope Electron transfer Bacterial nutrient transporter Density map Iron Interactions Cell-wall DDM E coli Bacteriocin Fourier Transform Infrared In vitro synthesis Isotope labelling Integral membrane protein complexes ATPase activity Hedgehog signal intrinsically disordered protein small-angle X-ray scattering Light Chemistry Dimyristoylphosphatidylcholine Bacillus subtilis