Inflammation-related prognostic markers in resected hepatocellular carcinoma. - Institut de recherche sur les maladies virales et hépatiques Accéder directement au contenu
Article Dans Une Revue Frontiers in Oncology Année : 2023

Inflammation-related prognostic markers in resected hepatocellular carcinoma.

Résumé

Hepatocellular carcinoma is usually detected late and therapeutic options are unsatisfactory. Despite marked progress in patient care, HCC remains among the deadliest cancers world-wide. While surgical resection remains a key option for early-stage HCC, the 5-year survival rates after surgical resection are limited. One reason for limited outcomes is the lack of reliable prognostic biomarkers to predict HCC recurrence. HCC prognosis has been shown to correlate with different systemic and pathological markers which are associated with patient survival and HCC recurrence. Liver inflammatory processes offer a large variety of systemic and pathological markers which may be exploited to improve the reliability of prognosis and decision making of liver surgeons and hepatologists. The following review aims to dissect the potential tools, targets and prognostic meaning of inflammatory markers in patients with resectable HCC. We analyze changes in circulant cellular populations and assess inflammatory biomarkers as a surrogate of impaired outcomes and provide an overview on predictive gene expression signatures including inflammatory transcriptional patterns, which are representative of poor survival in these patients.
Fichier principal
Vignette du fichier
islandora_170433.pdf (781.05 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04524182 , version 1 (27-03-2024)

Identifiants

Citer

Fabio Giannone, Nevena Slovic, Patrick Pessaux, Catherine Schuster, Thomas F. Baumert, et al.. Inflammation-related prognostic markers in resected hepatocellular carcinoma.. Frontiers in Oncology, 2023, 13, ⟨10.3389/fonc.2023.1267870⟩. ⟨hal-04524182⟩

Collections

SITE-ALSACE U1110
0 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More