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Article Dans Une Revue RNA Année : 2008

Distinctive structures between chimpanzee and human in a brain noncoding RNA.

Résumé

Human accelerated region 1 (HAR1) is a short DNA region identified recently to have evolved the most rapidly among highly constrained regions since the divergence from our common ancestor with chimpanzee. It is transcribed as part of a noncoding RNA specifically expressed in the developing human neocortex. Employing a panoply of enzymatic and chemical probes, our analysis of HAR1 RNA proposed a secondary structure model differing from that published. Most surprisingly, we discovered that the substitutions between the chimpanzee and human sequences led the human HAR1 RNA to adopt a cloverleaf-like structure instead of an extended and unstable hairpin in the chimpanzee sequence. Thus, the rapid evolutionary changes resulted in a profound rearrangement of HAR1 RNA structure. Altogether, our results provide a structural context for elucidating HAR1 RNA function.

Dates et versions

hal-00288341 , version 1 (16-06-2008)

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Citer

Artemy Beniaminov, Eric Westhof, Alain Krol. Distinctive structures between chimpanzee and human in a brain noncoding RNA.. RNA, 2008, epub ahead of print. ⟨10.1261/rna.1054608⟩. ⟨hal-00288341⟩

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