Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant {beta}-Lactamase from Klebsiella pneumoniae. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2008

Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant {beta}-Lactamase from Klebsiella pneumoniae.

Résumé

A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal blaSHV-56 gene, encoding a new inhibitor-resistant beta-lactamase of pI 7.6. SHV-56 derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

Dates et versions

hal-00319142 , version 1 (05-09-2008)

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Véronique Dubois, Laurent Poirel, François Demarthe, Corinne Arpin, Laure Coulange, et al.. Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant {beta}-Lactamase from Klebsiella pneumoniae.. Antimicrobial Agents and Chemotherapy, 2008, epub ahead of print. ⟨10.1128/AAC.00387-08⟩. ⟨hal-00319142⟩

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