Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 2008

Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions.

Frederic Geissman
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Bernhard Ryffel
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Résumé

IFN-producing killer dendritic cells (IKDC) were initially described as B220(+)CD11c(+)CD3(-)NK1.1(+) tumor-infiltrating cells that mediated part of the antitumor effects of the combination therapy with imatinib mesylate and IL-2. In this study, we show their functional dependency on IL-15 during homeostasis and inflammatory processes. Trans-presentation of IL-15 by IL-15Ralpha allows dramatic expansion of IKDC in vitro and in vivo, licenses IKDC for TRAIL-dependent killing and endows IKDC with immunizing potential, all three biological attributes not shared by B220(-)NK cells. However, IL-15 down-regulates the capacity of IKDC to induce MHC class I- or II-restricted T cell activation in vitro. Trans-presentation of IL-15 by IL-15Ralpha allows IKDC to respond to TLR3 and TLR4 ligands for the production of CCL2, a chemokine that is critical for IKDC trafficking into tumor beds (as described recently). We conclude that IKDC represent a unique subset of innate effectors functionally distinguishable from conventional NK cells in their ability to promptly respond to IL-15-driven inflammatory processes.

Domaines

Immunologie
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Dates et versions

hal-00363902 , version 1 (24-02-2009)

Identifiants

  • HAL Id : hal-00363902 , version 1
  • PUBMED : 18523252

Citer

Evelyn Ullrich, Mathieu Bonmort, Gregoire Mignot, Benedikt Jacobs, Daniela Bosisio, et al.. Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions.. Journal of Immunology, 2008, 180 (12), pp.7887-97. ⟨hal-00363902⟩
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