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Article Dans Une Revue Journal of Theoretical Biology Année : 2009

Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.

Résumé

Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.

Dates et versions

hal-00462362 , version 1 (09-03-2010)

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Citer

Christine Nazaret, Margit Heiske, Kevin Thurley, Jean-Pierre Mazat. Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.. Journal of Theoretical Biology, 2009, 258 (3), pp.455-64. ⟨10.1016/j.jtbi.2008.09.037⟩. ⟨hal-00462362⟩

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