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Article Dans Une Revue FEBS Letters Année : 2009

Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata.

E. Gilson
  • Fonction : Auteur
C. Fairhead
M. T. Teixeira
  • Fonction : Auteur

Résumé

Telomerase, the key enzyme essential for the maintenance of eukaryotic chromosome ends, contains a reverse transcriptase and an RNA that provides the template for the synthesis of telomeric repeats. Here, we characterize the telomerase subunits in the hemiascomycete yeast Candida glabrata. We propose a secondary structure model for the telomerase RNA that is the largest described to date. Telomerase deletion mutants show a progressive shortening of telomeres and a modest loss of viability. Frequent post-senescence survivors emerge that possess long telomeric repeat tracts. We suggest that the high telomere length heterogeneity accounts for this distinct senescence phenotype.

Dates et versions

hal-00477468 , version 1 (29-04-2010)

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Citer

R. Kachouri-Lafond, B. Dujon, E. Gilson, E. Westhof, C. Fairhead, et al.. Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata.. FEBS Letters, 2009, 583 (22), pp.3605-10. ⟨10.1016/j.febslet.2009.10.034⟩. ⟨hal-00477468⟩
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