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Article Dans Une Revue Vaccine Année : 2010

Sublingual immunization with an HIV subunit vaccine induces antibodies and cytotoxic T cells in the mouse female genital tract.

Résumé

A vaccine against heterosexual transmission by human immunodeficiency virus (HIV) should generate cytotoxic and antibody responses in the female genital tract and in extra-genital organs. We report that sublingual immunization with HIV-1 gp41 and a reverse transcriptase polypeptide coupled to the cholera toxin B subunit (CTB) induced gp41-specific IgA antibodies and antibody-secreting cells, as well as reverse transcriptase-specific CD8 T cells in the genital mucosa, contrary to intradermal immunization. Conjugation of the reverse transcriptase peptide to CTB favored its cross-presentation by human dendritic cells to a T cell line from an HIV(+) patient. Sublingual vaccination could represent a promising vaccine strategy against heterosexual transmission of HIV-1.

Domaines

Immunologie

Dates et versions

hal-00545804 , version 1 (13-12-2010)

Identifiants

Citer

Catherine Hervouet, Carmelo Luci, Nicolas Cuburu, Magali Cremel, Selma Bekri, et al.. Sublingual immunization with an HIV subunit vaccine induces antibodies and cytotoxic T cells in the mouse female genital tract.. Vaccine, 2010, 28 (34), pp.5582-90. ⟨10.1016/j.vaccine.2010.06.033⟩. ⟨hal-00545804⟩
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