Transcriptional mechanisms of developmental cell cycle arrest: problems and models. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Seminars in Cell and Developmental Biology Année : 2012

Transcriptional mechanisms of developmental cell cycle arrest: problems and models.

Résumé

Metazoans begin their life as a single cell. Then, this cell enters a more or less protracted period of active cell proliferation, which can be considered as the default cellular state. A crucial event, the developmental cell cycle exit, occurs thereafter. This phenomenon allows for differentiation to happen and regulates the final size of organs and organisms. Its control is still poorly understood. Herein, we review some transcriptional mechanisms of cell cycle exit in animals, and propose to use cellular conveyor belts as model systems for its study. We finally point to evidence that suggests that the mechanisms of developmental cell cycle arrest may have to be maintained in adult tissues.

Dates et versions

hal-00800356 , version 1 (13-03-2013)

Identifiants

Citer

Mathilde Devès, Franck Bourrat. Transcriptional mechanisms of developmental cell cycle arrest: problems and models.. Seminars in Cell and Developmental Biology, 2012, 23 (3), pp.290-7. ⟨10.1016/j.semcdb.2012.03.003⟩. ⟨hal-00800356⟩

Collections

CNRS INRA INRAE
27 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More