New genetic loci link adipose and insulin biology to body fat distribution. - CNRS - Centre national de la recherche scientifique Access content directly
Journal Articles Nature Year : 2015

New genetic loci link adipose and insulin biology to body fat distribution.

Dmitry Shungin (1, 2, 3) , Thomas W Winkler , Damien C Croteau-Chonka , Teresa Ferreira (4) , Adam E Locke , Reedik Mägi , Rona J Strawbridge (5) , Tune H Pers (6) , Krista Fischer , Anne E Justice , Tsegaselassie Workalemahu , Joseph M W Wu (7) , Martin L Buchkovich , Nancy L Heard-Costa , Tamara S Roman , Alexander W Drong , Ci Song , Stefan Gustafsson (8) , Felix R Day , Tonu Esko (9, 10) , Tove Fall (11) , Zoltán Kutalik (12) , Jian'An Luan , Joshua C Randall , André Scherag (13) , Sailaja Vedantam , Andrew R Wood , Jin Chen , Rudolf Fehrmann , Juha Karjalainen , Bratati Kahali , Ching-Ti Liu , Ellen M Schmidt (14) , Devin Absher , Najaf Amin (15) , Denise Anderson (16) , Marian Beekman , Jennifer L Bragg-Gresham (17) , Steven Buyske , Ayse Demirkan (15) , Georg B Ehret , Mary F Feitosa (18) , Anuj Goel , Anne U Jackson , Toby Johnson , Marcus E Kleber , Kati Kristiansson , Massimo Mangino (19) , Irene Mateo Leach , Carolina Medina-Gomez , Cameron D Palmer , Dorota Pasko , Sonali Pechlivanis , Marjolein J Peters , Inga Prokopenko , Alena Stančáková (20) , Yun Ju Sung , Toshiko Tanaka , Alexander Teumer (19) , Jana V van Vliet-Ostaptchouk (21) , Loïc Yengo (22) , Weihua Zhang , Eva Albrecht , Johan Ärnlöv , Gillian M Arscott , Stefania Bandinelli (23) , Amy Barrett (24) , Claire Bellis , Amanda J Bennett , Christian Berne , Matthias Blüher (25) , Stefan Böhringer , Fabrice Bonnet (26) , Yvonne Böttcher , Marcel Bruinenberg , Delia B Carba , Ida H Caspersen , Robert Clarke , E Warwick Daw , Joris Deelen , Ewa Deelman , Graciela Delgado , Alex S F Doney , Niina Eklund , Michael R Erdos , Karol Estrada (27, 28) , Elodie Eury , Nele Friedrich , Melissa E Garcia , Vilmantas Giedraitis , Bruna Gigante , Alan S Go , Alain Golay , Harald Grallert (29) , Tanja B Grammer , Jürgen Grässler , Jagvir Grewal , Christopher J Groves , Toomas Haller , Goran Hallmans (30) , Catharina A Hartman (31) , Maija Hassinen , Caroline Hayward (32) , Kauko Heikkilä (33) , Karl-Heinz Herzig , Quinta Helmer , Hans L Hillege (34) , Oddgeir Holmen , Steven C Hunt , Aaron Isaacs (19) , Till Ittermann , Alan L James (35) , Ingegerd Johansson (36) , Thorhildur Juliusdottir , Ioanna-Panagiota Kalafati , Leena Kinnunen , Wolfgang Koenig , Ishminder K Kooner , Wolfgang Kratzer , Claudia Lamina , Karin Leander , Nanette R Lee , Peter Lichtner (37) , Lars Lind , Jaana Lindström , Stéphane Lobbens (38) , Mattias Lorentzon , François Mach (39) , Patrik K E Magnusson (40) , Anubha Mahajan (41) , Wendy L Mcardle , Cristina Menni , Sigrun Merger , Evelin Mihailov , Lili Milani , Rebecca Mills , Alireza Moayyeri , Keri L Monda (42) , Simon P Mooijaart , Thomas W Mühleisen (43, 44) , Antonella Mulas , Gabriele Müller , Martina Müller-Nurasyid , Ramaiah Nagaraja (45) , Michael A Nalls (46) , Narisu Narisu , Nicola Glorioso , Ilja M Nolte (19) , Matthias Olden , Nigel W Rayner (47) , Frida Renstrom (48, 1, 2) , Janina S Ried (49) , Neil R Robertson , Lynda M Rose , Serena Sanna , Hubert Scharnagl , Salome Scholtens , Bengt Sennblad , Thomas Seufferlein , Colleen M Sitlani , Albert Vernon Smith , Kathleen Stirrups , Heather M Stringham (17) , Johan Sundström (50) , Morris A Swertz (51) , Amy J Swift , Ann-Christine Syvänen (5) , Bamidele O Tayo , Barbara Thorand (29) , Gudmar Thorleifsson (52) , Andreas Tomaschitz , Chiara Troffa , Floor V A van Oort , Niek Verweij , Judith M Vonk (53) , Lindsay L Waite , Roman Wennauer , Tom Wilsgaard , Mary K Wojczynski , Andrew Wong , Qunyuan Zhang , Jing Hua Zhao , Eoin P Brennan , Murim Choi , Per Eriksson , Lasse Folkersen , Anders Franco-Cereceda , Ali G Gharavi , Åsa K Hedman , Marie-France Hivert , Jinyan Huang , Stavroula Kanoni (54) , Fredrik Karpe , Sarah Keildson , Krzysztof Kiryluk , Liming Liang , Richard P Lifton (55) , Baoshan Ma , Amy J Mcknight , Ruth Mcpherson , Andres Metspalu (9, 10) , Josine L Min , Miriam F Moffatt (56) , Grant W Montgomery (15, 57) , Joanne M Murabito , George Nicholson (58) , Dale R Nyholt (31) , Christian Olsson , John R B Perry , Eva Reinmaa , Rany M Salem , Niina Sandholm , Eric E Schadt , Robert A Scott , Lisette Stolk , Edgar E Vallejo , Harm-Jan Westra , Krina T Zondervan , Philippe Amouyel (59) , Dominique Arveiler (60) , Stephan J L Bakker (61) , John Beilby , Richard N Bergman , John Blangero , Morris J Brown , Michel Burnier , Harry Campbell , Aravinda Chakravarti (19) , Peter S Chines , Simone Claudi-Boehm , Francis S Collins , Dana C Crawford , John Danesh (62) , Ulf de Faire , Eco J C de Geus (31) , Marcus Dörr , Raimund Erbel (63) , Johan G Eriksson , Martin Farrall (64) , Ele Ferrannini (65) , Jean Ferrières , Nita G Forouhi (66) , Terrence Forrester , Oscar H Franco (67) , Ron T Gansevoort (68) , Christian Gieger (69) , Vilmundur Gudnason (70, 71) , Christopher A Haiman , Tamara B Harris (72) , Andrew T Hattersley , Markku Heliövaara , Andrew A Hicks (73) , Aroon D Hingorani , Wolfgang Hoffmann (74) , Albert Hofman (75, 15) , Georg Homuth (76) , Steve E Humphries (77) , Elina Hyppönen (78, 79) , Thomas Illig (80) , Marjo-Riitta Jarvelin (81, 82, 83) , Berit Johansen , Pekka Jousilahti , Antti M Jula , Jaakko Kaprio (15) , Frank Kee (84) , Sirkka M Keinanen-Kiukaanniemi , Jaspal S Kooner (85) , Charles Kooperberg , Peter Kovacs (86) , Aldi T Kraja , Meena Kumari (87) , Kari Kuulasmaa , Johanna Kuusisto (20) , Timo A Lakka (88) , Claudia Langenberg (66) , Loic Le Marchand (89) , Terho Lehtimäki (90) , Valeriya Lyssenko , Satu Männistö (91) , André Marette (92) , Tara C Matise , Colin A Mckenzie , Barbara Mcknight , Arthur W Musk , Stefan Möhlenkamp (63) , Andrew D Morris , Mari Nelis , Claes Ohlsson (93) , Albertine J Oldehinkel (94) , Ken K Ong (95) , Lyle J Palmer , Brenda W Penninx (15) , Annette Peters , Peter P Pramstaller (32) , Olli T Raitakari (96, 97) , Tuomo Rankinen , D C Rao , Treva K Rice , Paul M Ridker (98) , Marylyn D Ritchie , Igor Rudan (32) , Veikko Salomaa (99) , Nilesh J Samani (100, 101) , Jouko Saramies , Mark A Sarzynski , Peter E H Schwarz , Alan R Shuldiner , Jan A Staessen (102) , Valgerdur Steinthorsdottir , Ronald P Stolk , Konstantin Strauch , Anke Tönjes , Angelo Tremblay , Elena Tremoli , Marie-Claude Vohl , Uwe Völker (76) , Peter Vollenweider , James F Wilson , Jacqueline C Witteman (19) , Linda S Adair , Murielle Bochud (103) , Bernhard O Boehm , Stefan R Bornstein (104) , Claude Bouchard (105) , Stéphane Cauchi (106) , Mark J Caulfield (107) , John C Chambers , Daniel I Chasman (98) , Richard S Cooper , George Dedoussis (54) , Luigi Ferrucci (31) , Philippe Froguel (108) , Hans-Jörgen Grabe (109) , Anders Hamsten (110) , Jennie Hui , Kristian Hveem , Karl-Heinz Jöckel (111) , Mika Kivimaki (87) , Diana Kuh (112) , Markku Laakso (20) , Yongmei Liu , Winfried März (113) , Patricia B Munroe (107) , Inger Njølstad , Ben A Oostra (19) , Colin N A Palmer , Nancy L Pedersen (114) , Markus Perola (115, 116) , Louis Pérusse (2) , Ulrike Peters , Chris Power , Thomas Quertermous , Rainer Rauramaa , Fernando Rivadeneira (27) , Timo E Saaristo , Danish Saleheen , Juha Sinisalo , P Eline Slagboom , Harold Snieder (117, 118) , Tim D Spector (19) , Unnur Thorsteinsdottir (52) , Michael Stumvoll , Jaakko Tuomilehto (119, 120, 121) , André G Uitterlinden (122, 75, 15) , Matti Uusitupa (123) , Pim van Der Harst , Giovanni Veronesi , Mark Walker , Nicholas J Wareham (124) , Hugh Watkins , H-Erich Wichmann (125) , Goncalo R Abecasis (31) , Themistocles L Assimes , Sonja I Berndt (126) , Michael Boehnke (17) , Ingrid B Borecki (18) , Panos Deloukas (47) , Lude Franke , Timothy M Frayling (127) , Leif C Groop (1) , David J Hunter , Robert C Kaplan , Jeffrey R O'Connell , Lu Qi , David Schlessinger (31) , David P Strachan , Kari Stefansson (52) , Cornelia M van Duijn , Cristen J Willer , Peter M Visscher (128) , Jian Yang (129) , Joel N Hirschhorn (130, 131) , M Carola Zillikens (122, 75) , Mark I Mccarthy , Elizabeth K Speliotes , Kari E North (132) , Caroline S Fox , Inês Barroso (133, 134) , Paul W Franks , Erik Ingelsson (11) , Iris M Heid (135) , Ruth J F Loos (136) , L Adrienne Cupples (137) , Andrew P Morris , Cecilia M Lindgren (64, 138) , Karen L Mohlke (139)
1 Department of Clinical Sciences
2 Genetic Epidemiology and Clinical Research Group
3 Department of Odontology
4 STIM [Poitiers] - Signalisation et Transports Ioniques Membranaires
5 Department of Medical Sciences
6 Center for Biological Sequence Analysis [Lyngby]
7 LIST - Laboratory of Image Science and Technology [Nanjing]
8 Limnology
9 Estonian Genome and Medicine
10 Institute of Molecular and Cell Biology
11 MEB - Department of Medical Epidemiology and Biostatistics
12 Department of Medical Genetics
13 Institute of Medical Informatics, Biometry and Epidemiology
14 CIML - Centre d'Immunologie de Marseille - Luminy
15 Genetic Epidemiology Unit
16 SSL - Space Sciences Laboratory [Berkeley]
17 Department of Biostatistics and Center for Statistical Genetics
18 Division of Statistical Genomics
19 King‘s College London
20 Department of Medicine
21 Molecular Genetics Section
22 EGENODIA (GI3M) - Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283
23 Geriatric Rehabilitation Unit
24 Department of Pharmacy Sciences
25 Medical Department III
26 Foie, métabolismes et cancer
27 Department of Epidemiology
28 Netherlands Genomics Initiative (NGI)
29 EPI - Institute of Epidemiology [Neuherberg]
30 Department of Public Health and Clinical Medicine
31 Medstar Research Institute
32 Genetics and Pathology
33 Finnish Institute of Occupational Health
34 Epidemiology
35 Departments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry
36 Department of Odontology, Cariology
37 Institute of Human Genetics
38 GMM - Génétique des maladies multifactorielles
39 Division of Cardiology
40 Department of Psychiatry and Psychotherapy
41 Department of Physics
42 Department of Epidemiology
43 Department of Genomics, Life and Brain Center
44 Institute of Human Genetics
45 Anaesthesia and Intensive care
46 UCL Institute of neurology
47 Human Genetics
48 Departments of Epidemiology and Nutrition
49 Institute of Experimental Medicine
50 Department of Medical Sciences and Uppsala Clinical Research Center
51 Department of Genetics
52 deCODE Genetics
53 Pediatric Pulmonology, Allergology & Epidemiology
54 Department of Nutrition-Dietetics
55 Department of Genetics
56 NHLI - National Heart and Lung Institute
57 Queensland Institute of Medical Research
58 Concord Hospital
59 Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations
60 Dept. Atherosclerose
61 Kidney Center
62 Department of Public Health & Primary Care
63 Department of cardiology
64 The Wellcome Trust Centre for Human Genetics [Oxford]
65 Department of Internal Medicine
66 MRC Epidemiology Unit
67 Health Sciences Research Institute
68 Department of Nephrology
69 Institute of Genetic Epidemiology
70 Icelandic Heart Association
71 University of Iceland [Reykjavik]
72 Executive Board
73 Department of Zoology
74 Institute for Community Medicine, Department Epidemiology of Health Care and Community Health
75 Department of Internal Medicine
76 Interfaculty Institute for Genetics and Functional Genomics
77 Department of Medicine
78 Centre for Paediatric Epidemiology and Biostatistics
79 MRC Centre for Epidemiology of Child Health
80 Unit for Molecular Epidemiology
81 Institute of Health Sciences and Biocenter Oulu
82 Department of Epidemiology and Biostatistics
83 Department of Life Course and Services
84 Department of Epidemiology and Public Health
85 Imperial College London
86 Interdisciplinary Center of Clinical Research
87 Department of Epidemiology and Public Health
88 Department of Physiology
89 UHM - University of Hawai‘i [Mānoa]
90 Department of Clinical Chemistry
91 Chronic Disease Epidemiology and Prevention Unit
92 ULaval - Université Laval [Québec]
93 Centre for Bone and Arthritis Research
94 Interdisciplinary Center for Psychiatric Epidemiology
95 Medical Research Council Epidemiology Unit, Institute of Metabolic Science
96 The Research Centre of Applied and Preventive Cardiovascular Medicine
97 Department of Clinical Physiology
98 Brigham and Women's Hospital [Boston]
99 Department of Chronic Disease Prevention
100 Department of Cardiovascular Sciences [Leicester]
101 Leicester NIHR Biomedical Research Unit in Cardiovascular Disease
102 Department of Epidemiology
103 Institute of Social and Preventive Medicine
104 Carl Gustav Carus University Hospital
105 EA 4050 - Recherches en Psychopathologie, nouveaux symptômes et lien social
106 IBL - Institut de biologie de Lille - UMS 3702
107 Institute of Molecular and Cell Biology
108 IC UM3 (UMR 8104 / U1016) - Institut Cochin
109 Department of Psychiatry and Psychotherapy
110 Department of Child and Adolescent Psychiatry
111 Institute for Medical Informatics, Biometry, and Epidemiology
112 MRC National Survey of Health and Development
113 Clinical Institute of Medical and Chemical Laboratory Diagnostics
114 Peter MacCallum Cancer Center
115 FIMM - Institute for Molecular Medicine Finland [Helsinki]
116 Department of Chronic Disease Prevention
117 University of Groningen [Groningen]
118 Department of Pediatrics
119 Department of Public Health
120 South Ostrobothnia Central Hospital
121 Department of Clinical and Preventive Medicine
122 Netherlands Genomics Initiative
123 Institute of Public Health and Clinical Nutrition
124 MRC epidemiology Unit
125 Institute of Epidemiology
126 Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics
127 Department of Oncology
128 Queensland Brain Institute
129 Harvard Reproductive Sciences Center and Reproductive Endocrine Unit
130 Divisions of Genetics and Endocrinology and Program in Genomics
131 Metabolism Initiative and Program in Medical and Population Genetics
132 Department of Epidemiology
133 Metabolic Disease Group
134 University of Cambridge Metabolic Research Laboratories
135 Department of Epidemiology and Preventive Medicine
136 Epidemiology Unit
137 Framingham Heart Study
138 Endocrinology and Metabolism
139 Department of Genetics
Thomas W Winkler
  • Function : Author
Damien C Croteau-Chonka
  • Function : Author
Adam E Locke
  • Function : Author
Reedik Mägi
  • Function : Author
Krista Fischer
  • Function : Author
Anne E Justice
  • Function : Author
Tsegaselassie Workalemahu
  • Function : Author
Martin L Buchkovich
  • Function : Author
Nancy L Heard-Costa
  • Function : Author
Tamara S Roman
  • Function : Author
Alexander W Drong
  • Function : Author
Ci Song
  • Function : Author
Stefan Gustafsson
  • Function : Author
Felix R Day
  • Function : Author
Jian'An Luan
  • Function : Author
Joshua C Randall
  • Function : Author
Sailaja Vedantam
  • Function : Author
Andrew R Wood
  • Function : Author
Jin Chen
  • Function : Author
Rudolf Fehrmann
  • Function : Author
Juha Karjalainen
  • Function : Author
Bratati Kahali
  • Function : Author
Ching-Ti Liu
  • Function : Author
Devin Absher
  • Function : Author
Marian Beekman
  • Function : Author
Steven Buyske
  • Function : Author
Georg B Ehret
  • Function : Author
Anuj Goel
  • Function : Author
Anne U Jackson
  • Function : Author
Toby Johnson
  • Function : Author
Marcus E Kleber
  • Function : Author
Kati Kristiansson
  • Function : Author
Irene Mateo Leach
  • Function : Author
Carolina Medina-Gomez
  • Function : Author
Cameron D Palmer
  • Function : Author
Dorota Pasko
  • Function : Author
Sonali Pechlivanis
  • Function : Author
Marjolein J Peters
  • Function : Author
Inga Prokopenko
  • Function : Author
Yun Ju Sung
  • Function : Author
Toshiko Tanaka
  • Function : Author
Weihua Zhang
  • Function : Author
Eva Albrecht
  • Function : Author
Johan Ärnlöv
Gillian M Arscott
  • Function : Author
Claire Bellis
Amanda J Bennett
  • Function : Author
Christian Berne
  • Function : Author
Matthias Blüher
Stefan Böhringer
  • Function : Author
Yvonne Böttcher
  • Function : Author
Marcel Bruinenberg
  • Function : Author
Delia B Carba
  • Function : Author
Ida H Caspersen
  • Function : Author
Robert Clarke
  • Function : Author
E Warwick Daw
  • Function : Author
Joris Deelen
  • Function : Author
Ewa Deelman
  • Function : Author
Graciela Delgado
  • Function : Author
Alex S F Doney
  • Function : Author
Niina Eklund
  • Function : Author
Michael R Erdos
  • Function : Author
Elodie Eury
  • Function : Author
Nele Friedrich
  • Function : Author
Melissa E Garcia
  • Function : Author
Vilmantas Giedraitis
  • Function : Author
Bruna Gigante
  • Function : Author
Alan S Go
  • Function : Author
Alain Golay
  • Function : Author
Harald Grallert
Tanja B Grammer
  • Function : Author
Jürgen Grässler
  • Function : Author
Jagvir Grewal
  • Function : Author
Christopher J Groves
  • Function : Author
Toomas Haller
  • Function : Author
Maija Hassinen
  • Function : Author
Karl-Heinz Herzig
  • Function : Author
Quinta Helmer
  • Function : Author
Hans L Hillege
  • Function : Author
Oddgeir Holmen
  • Function : Author
Steven C Hunt
  • Function : Author
Till Ittermann
  • Function : Author
Thorhildur Juliusdottir
  • Function : Author
Ioanna-Panagiota Kalafati
  • Function : Author
Leena Kinnunen
  • Function : Author
Wolfgang Koenig
  • Function : Author
Ishminder K Kooner
  • Function : Author
Wolfgang Kratzer
  • Function : Author
Claudia Lamina
  • Function : Author
Karin Leander
Nanette R Lee
  • Function : Author
Lars Lind
Jaana Lindström
  • Function : Author
Mattias Lorentzon
  • Function : Author
Wendy L Mcardle
  • Function : Author
Cristina Menni
  • Function : Author
Sigrun Merger
  • Function : Author
Evelin Mihailov
  • Function : Author
Lili Milani
  • Function : Author
Rebecca Mills
  • Function : Author
Alireza Moayyeri
  • Function : Author
Simon P Mooijaart
  • Function : Author
Antonella Mulas
  • Function : Author
Gabriele Müller
  • Function : Author
Martina Müller-Nurasyid
Narisu Narisu
  • Function : Author
Nicola Glorioso
  • Function : Author
Matthias Olden
  • Function : Author
Nigel W Rayner
  • Function : Author
Neil R Robertson
  • Function : Author
Lynda M Rose
  • Function : Author
Serena Sanna
  • Function : Author
Hubert Scharnagl
  • Function : Author
Salome Scholtens
  • Function : Author
Bengt Sennblad
  • Function : Author
Thomas Seufferlein
  • Function : Author
Colleen M Sitlani
  • Function : Author
Albert Vernon Smith
  • Function : Author
Kathleen Stirrups
  • Function : Author
Amy J Swift
  • Function : Author
Bamidele O Tayo
  • Function : Author
Andreas Tomaschitz
  • Function : Author
Chiara Troffa
  • Function : Author
Floor V A van Oort
  • Function : Author
Niek Verweij
  • Function : Author
Lindsay L Waite
  • Function : Author
Roman Wennauer
  • Function : Author
Tom Wilsgaard
  • Function : Author
Mary K Wojczynski
  • Function : Author
Andrew Wong
  • Function : Author
Qunyuan Zhang
  • Function : Author
Jing Hua Zhao
  • Function : Author
Eoin P Brennan
  • Function : Author
Murim Choi
  • Function : Author
Per Eriksson
  • Function : Author
Lasse Folkersen
  • Function : Author
Anders Franco-Cereceda
  • Function : Author
Ali G Gharavi
  • Function : Author
Åsa K Hedman
  • Function : Author
Marie-France Hivert
Jinyan Huang
  • Function : Author
Fredrik Karpe
  • Function : Author
Sarah Keildson
  • Function : Author
Krzysztof Kiryluk
  • Function : Author
Liming Liang
  • Function : Author
Baoshan Ma
  • Function : Author
Amy J Mcknight
  • Function : Author
Ruth Mcpherson
  • Function : Author
Josine L Min
  • Function : Author
Joanne M Murabito
  • Function : Author
Christian Olsson
  • Function : Author
John R B Perry
  • Function : Author
Eva Reinmaa
  • Function : Author
Rany M Salem
  • Function : Author
Niina Sandholm
  • Function : Author
Eric E Schadt
  • Function : Author
Robert A Scott
  • Function : Author
Lisette Stolk
  • Function : Author
Edgar E Vallejo
  • Function : Author
Harm-Jan Westra
  • Function : Author
Krina T Zondervan
  • Function : Author
Stephan J L Bakker
  • Function : Author
John Beilby
  • Function : Author
Richard N Bergman
  • Function : Author
John Blangero
  • Function : Author
Morris J Brown
  • Function : Author
Michel Burnier
Harry Campbell
  • Function : Author
Peter S Chines
  • Function : Author
Simone Claudi-Boehm
  • Function : Author
Francis S Collins
  • Function : Author
Dana C Crawford
  • Function : Author
Ulf de Faire
  • Function : Author
Marcus Dörr
  • Function : Author
Johan G Eriksson
  • Function : Author
Jean Ferrières
Terrence Forrester
  • Function : Author
Christopher A Haiman
  • Function : Author
Tamara B Harris
  • Function : Author
Andrew T Hattersley
  • Function : Author
Markku Heliövaara
  • Function : Author
Aroon D Hingorani
  • Function : Author
Berit Johansen
  • Function : Author
Pekka Jousilahti
  • Function : Author
Antti M Jula
  • Function : Author
Sirkka M Keinanen-Kiukaanniemi
  • Function : Author
Charles Kooperberg
  • Function : Author
Aldi T Kraja
  • Function : Author
Kari Kuulasmaa
  • Function : Author
Valeriya Lyssenko
  • Function : Author
Tara C Matise
  • Function : Author
Colin A Mckenzie
  • Function : Author
Barbara Mcknight
  • Function : Author
Arthur W Musk
  • Function : Author
Andrew D Morris
  • Function : Author
Mari Nelis
  • Function : Author
Lyle J Palmer
  • Function : Author
Annette Peters
Tuomo Rankinen
  • Function : Author
D C Rao
  • Function : Author
Treva K Rice
  • Function : Author
Marylyn D Ritchie
  • Function : Author
Jouko Saramies
  • Function : Author
Mark A Sarzynski
  • Function : Author
Peter E H Schwarz
  • Function : Author
Alan R Shuldiner
  • Function : Author
Valgerdur Steinthorsdottir
  • Function : Author
Ronald P Stolk
  • Function : Author
Konstantin Strauch
  • Function : Author
Anke Tönjes
  • Function : Author
Angelo Tremblay
  • Function : Author
  • PersonId : 928538
Elena Tremoli
  • Function : Author
Marie-Claude Vohl
  • Function : Author
Peter Vollenweider
  • Function : Author
James F Wilson
  • Function : Author
Linda S Adair
  • Function : Author
Bernhard O Boehm
  • Function : Author
Stéphane Cauchi
John C Chambers
  • Function : Author
Richard S Cooper
  • Function : Author
George Dedoussis
Philippe Froguel
  • Function : Author
Jennie Hui
  • Function : Author
Kristian Hveem
  • Function : Author
Yongmei Liu
  • Function : Author
Inger Njølstad
  • Function : Author
Colin N A Palmer
  • Function : Author
Ulrike Peters
  • Function : Author
Chris Power
  • Function : Author
Thomas Quertermous
  • Function : Author
Rainer Rauramaa
  • Function : Author
Timo E Saaristo
  • Function : Author
Danish Saleheen
  • Function : Author
Juha Sinisalo
  • Function : Author
P Eline Slagboom
  • Function : Author
Michael Stumvoll
  • Function : Author
Pim van Der Harst
  • Function : Author
Giovanni Veronesi
  • Function : Author
Mark Walker
  • Function : Author
Hugh Watkins
  • Function : Author
Goncalo R Abecasis
  • Function : Author
  • PersonId : 948452
Themistocles L Assimes
  • Function : Author
Panos Deloukas
  • Function : Author
Lude Franke
  • Function : Author
David J Hunter
  • Function : Author
Robert C Kaplan
  • Function : Author
Jeffrey R O'Connell
  • Function : Author
Lu Qi
  • Function : Author
David P Strachan
  • Function : Author
Kari Stefansson
  • Function : Author
Cornelia M van Duijn
  • Function : Author
Cristen J Willer
  • Function : Author
Mark I Mccarthy
  • Function : Author
Elizabeth K Speliotes
  • Function : Author
Caroline S Fox
  • Function : Author
Paul W Franks
  • Function : Author
Ruth J F Loos
  • Function : Author
Andrew P Morris
  • Function : Author

Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

Dates and versions

hal-01132692 , version 1 (17-03-2015)

Identifiers

Cite

Dmitry Shungin, Thomas W Winkler, Damien C Croteau-Chonka, Teresa Ferreira, Adam E Locke, et al.. New genetic loci link adipose and insulin biology to body fat distribution.. Nature, 2015, 518 (7538), pp.187-96. ⟨10.1038/nature14132⟩. ⟨hal-01132692⟩
982 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More