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Article Dans Une Revue Cell Reports Année : 2015

Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons

Serge Picaud

Résumé

OTX2 (orthodenticle homeobox 2) haplodeficiency causes diverse defects in mammalian visual systems ranging from retinal dysfunction to anophthalmia. We find that the retinal dystrophy of Otx2+/GFP heterozygous knockin mice is mainly due to the loss of bipolar cells and consequent deficits in retinal activity. Among bipolar cell types, OFF-cone bipolar subsets, which lack autonomous Otx2 gene expression but receive Otx2 proteins from photoreceptors, degenerate most rapidly in Otx2+/GFP mouse retinas, suggesting a neuroprotective effect of the imported Otx2 protein. In support of this hypothesis, retinal dystrophy in Otx2+/GFP mice is prevented by intraocular injection of Otx2 protein, which localizes to the mitochondria of bipolar cells and facilitates ATP synthesis as a part of mitochondrial ATP synthase complex. Taken together, our findings demonstrate a mitochondrial function for Otx2 and suggest a potential therapeutic application of OTX2 protein delivery in human retinal dystrophy.
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Dates et versions

hal-01224993 , version 1 (05-11-2015)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Hyoung-Tai Kim, Soung jung Kim, Young-In Sohn, Sun-Sook Paik, Romain Caplette, et al.. Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons. Cell Reports, 2015, 13 (5), pp.990-1002. ⟨10.1016/j.celrep.2015.09.075⟩. ⟨hal-01224993⟩
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