Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Blood Année : 2015

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Panagiotis Baliakas
Zadie Davis
Silvio Veronese
Anne Gardiner
  • Fonction : Auteur
Karin Ekström Smedby
  • Fonction : Auteur
  • PersonId : 887297
Véronique Giudicelli
Gunnar Juliusson
  • Fonction : Auteur
  • PersonId : 887300
Marie-Paule Lefranc
Sarka Pospisilova
David Oscier
  • Fonction : Auteur
Frederic Davi

Résumé

An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5%) used the IGHV3-21 gene with 254/437 (58%) classified as subset #2. Within subset #2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non–subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P = .002). Subset #2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non–subset #2/IGHV3-21 (22 vs 60 months, P = .001). No such difference was observed between non–subset #2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status. In conclusion, IGHV3-21 CLL should not be axiomatically considered a homogeneous entity with adverse prognosis, given that only subset #2 emerges as uniformly aggressive, contrasting non–subset #2/IGVH3-21 patients whose prognosis depends on IGHV mutational status as the remaining CLL.
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Dates et versions

hal-01265855 , version 1 (14-12-2023)

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Panagiotis Baliakas, Andreas Agathangelidis, Anastasia C Hadzidimitriou, Lesley-Ann Sutton, Eva Minga, et al.. Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. Blood, 2015, 125 (5), pp.856-859. ⟨10.1182/blood-2014-09-600874⟩. ⟨hal-01265855⟩
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