Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Leukemia Research Année : 2016

Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia

Arsène Mekinian
Eric Grignano
  • Fonction : Auteur
Guillaume Denis
  • Fonction : Auteur
Gwenola Maigne
  • Fonction : Auteur
Achille Aouba
  • Fonction : Auteur
Nathalie Leon
  • Fonction : Auteur
Eric Liozon
  • Fonction : Auteur
Julien Rossignol
  • Fonction : Auteur
Olivier Fain

Résumé

This retrospective study describes efficacy of Azacitidine on autoimmune disorders (AID) associated with MDS/CMML in 22 patients. Response of AID to Azacitidine was observed in 19 patients (86%). Reduction or discontinuation of steroids and/or immunosuppressive therapy (IST) was possible in 16 cases (73%). Hematologic response was seen in 55% of the patients. MDS/CMML and AID evolution was concordant in 13 cases (59%): both favorable (n = 11), both unfavorable (n = 2), but AID improved while MDS/CMML worsened (n = 8) and vice versa (n = 1). Azacitidine frequently seems effective in controlling steroid-dependent AID associated with MDS/CMML, but prospective studies are necessary to confirm those findings

Domaines

Cancer
Fichier principal
Vignette du fichier
Efficacy of Azacitidine in Autoimmune and Inflammatory.pdf (244.84 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01278608 , version 1 (07-06-2016)

Identifiants

Citer

Jean-Baptiste Fraison, Arsène Mekinian, Eric Grignano, Jean-Emmanuel Kahn, Jean-Benoit Arlet, et al.. Efficacy of Azacitidine in Autoimmune and Inflammatory Disorders associated with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. Leukemia Research, 2016, 43, pp.13-17. ⟨10.1016/j.leukres.2016.02.005⟩. ⟨hal-01278608⟩
721 Consultations
1382 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More