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Article Dans Une Revue Development Année : 2015

BMP signalling controls the construction of vertebrate mucociliary epithelia

Résumé

Despite the importance of mucociliary epithelia in animal physiology, the mechanisms controlling their establishment are poorly understood. Using the developing Xenopus epidermis and regenerating human upper airways, we reveal the importance of BMP signalling for the construction of vertebrate mucociliary epithelia. In Xenopus, attenuation of BMP activity is necessary for the specification of multiciliated cells (MCCs), ionocytes and small secretory cells (SSCs). Conversely, BMP activity is required for the proper differentiation of goblet cells. Our data suggest that the BMP and Notch pathways interact to control fate choices in the developing epidermis. Unexpectedly, BMP activity is also necessary for the insertion of MCCs, ionocytes and SSCs into the surface epithelium. In human, BMP inhibition also strongly stimulates the formation of MCCs in normal and pathological (cystic fibrosis) airway samples, whereas BMP overactivation has the opposite effect. This work identifies the BMP pathway as a key regulator of vertebrate mucociliary epithelium differentiation and morphogenesis.

Dates et versions

hal-01432231 , version 1 (11-01-2017)

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M. Cibois, G. Luxardi, B. Chevalier, V. Thome, O. Mercey, et al.. BMP signalling controls the construction of vertebrate mucociliary epithelia. Development, 2015, 142 (13), pp.2352-63. ⟨10.1242/dev.118679⟩. ⟨hal-01432231⟩
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