Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP- Sm PoMuc interaction - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Developmental and Comparative Immunology Année : 2017

Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP- Sm PoMuc interaction

Résumé

The fresh water snail Biomphalaria glabrata is one of the vectors of the trematode pathogen Schistosoma mansoni, which is one of the agents responsible of human schistosomiasis. In this hosteparasite interaction, co-evolutionary dynamic results into an infectivity mosaic known as compatibility polymorphism. Integrative approaches including large scale molecular approaches have been conducted in recent years to improve our understanding of the mechanisms underlying compatibility. This review presents the combination of integrated Multi-Omic approaches leading to the discovery of two repertoires of polymorphic and/or diversified interacting molecules: the parasite antigens S. mansoni polymorphic mucins (SmPoMucs) and the B. glabrata immune receptors fibrinogen-related proteins (FREPs). We argue that their interactions may be major components for defining the compatible/ incompatible status of a specific snail/schistosome combination
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hal-01598455 , version 1 (04-02-2021)

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Anaïs Portet, Silvain Pinaud, Guillaume Tetreau, Richard Galinier, Celine Cosseau, et al.. Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP- Sm PoMuc interaction. Developmental and Comparative Immunology, 2017, 75, pp.16 - 27. ⟨10.1016/j.dci.2017.02.025⟩. ⟨hal-01598455⟩
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