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Article Dans Une Revue Journal of Magnetism and Magnetic Materials Année : 2017

A compound magnetic field generating system for targeted killing of Staphylococcus aureus by magnetotactic bacteria in a microfluidic chip

Changyou Chen
  • Fonction : Auteur
Pingping Wang
  • Fonction : Auteur
Chuanfang Chen
  • Fonction : Auteur
Long-Fei Wu
Tao Song
  • Fonction : Auteur

Résumé

A compound magnetic field generating system was built to kill Staphylococcus aureus (S. aureus) by magnetotactic bacteria (MTB) in a microfluidic chip in this paper. The system was consisted of coil pairs, a switch circuit, a control program and controllable electrical sources. It could produce a guiding magnetic field (gMF) of +/- 1 mT along arbitrary direction in the horizontal plane, a rotating magnetic field (rMF) and a swing magnetic field (sMF, 2 Hz, 10 mT) by controlling the currents. The gMF was used to guide MTB swimming to the S. aureus pool in the microfluidic chip, and then the rMF enhanced the mixture of S. aureus and MTB cells, therefore beneficial to the attachments of them. Finally, the sMF was used to induce the death of S. aureus via MTB. The results showed that MTB could be navigated by the gMF and that 47.1% of S. aureus were killed when exposed to the sMF. It provides a new solution for the targeted treatment of infected diseases and even cancers.
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Dates et versions

hal-01640029 , version 1 (20-11-2017)

Identifiants

Citer

Linjie Chen, Changyou Chen, Pingping Wang, Chuanfang Chen, Long-Fei Wu, et al.. A compound magnetic field generating system for targeted killing of Staphylococcus aureus by magnetotactic bacteria in a microfluidic chip. Journal of Magnetism and Magnetic Materials, 2017, 427, pp.90--94. ⟨10.1016/j.jmmm.2016.10.109⟩. ⟨hal-01640029⟩
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