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Article Dans Une Revue Journal of Alzheimer's Disease Année : 2018

PCSK9 Concentrations in Cerebrospinal Fluid Are Not Specifically Increased in Alzheimer's Disease

Résumé

The role of PCSK9 in Alzheimer's disease (AD) is controversial. We compared cerebrospinal fluid (CSF) PCSK9 concentrations in 36 AD and 31 non-AD patients. CSF PCSK9 levels did not differ between AD and non-AD groups (2.80 versus 2.62 ng/mL). However, PCSK9 CSF levels were increased in AD and non-AD patients with other neurodegenerative process (non-AD ND, n = 20) compared to patients without neurodegenerative disorders (non-ND, n = 11): 2.80 versus 2.30 (p \textless 0.005) and 2.83 versus 2.30 ng/mL (p = NS), respectively. CSF PCSK9 were positively correlated with AD biomarkers (Aβ1-42, T-tau, and P-tau). PCSK9 concentrations in CSF are increased in neurodegenerative disorders rather than specifically in AD.
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Dates et versions

hal-01833920 , version 1 (10-07-2018)

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Hélène Courtemanche, Edith Bigot, Matthieu Pichelin, Béatrice Guyomarch, Claire Boutoleau-Bretonnière, et al.. PCSK9 Concentrations in Cerebrospinal Fluid Are Not Specifically Increased in Alzheimer's Disease. Journal of Alzheimer's Disease, 2018, Equipe IV, ⟨10.3233/JAD-170993⟩. ⟨hal-01833920⟩
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