Staphylococcal Adhesion and Host Cell Invasion: Fibronectin-Binding and Other Mechanisms - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Frontiers in Microbiology Année : 2017

Staphylococcal Adhesion and Host Cell Invasion: Fibronectin-Binding and Other Mechanisms

Résumé

Opportunistic bacteria from the genus Staphylococcus can cause life-threatening infections such as pneumonia, endocarditis, bone and joint infections, and sepsis. This pathogenicity is closely related to their capacity to bind directly to the extracellular matrix or to host cells. Adhesion is indeed the first step in the formation of biofilm or the invasion of host cells, which protect the bacteria from the host immune system and facilitate chronic infection. Adhesion relies on the expression of a repertoire of surface proteins called adhesins, notably microbial surface components recognizing adhesive matrix molecules. In this short review, we discuss the main pathway (FnBP-Fn-α5β1 integrin), as well as alternatives, through which Staphylococcus aureus adheres to and then invades non-professional phagocytic cells. We then examine the corresponding mechanisms for coagulase negative staphylococci. There is currently a little understanding of the molecular mechanisms that lead to internalization. Filling this gap in the literature would therefore be an important step toward limiting the duration of staphylococci infections in clinical practice.

Dates et versions

hal-01911203 , version 1 (02-11-2018)

Identifiants

Citer

Jérôme Josse, Frédéric Laurent, Alan Diot. Staphylococcal Adhesion and Host Cell Invasion: Fibronectin-Binding and Other Mechanisms. Frontiers in Microbiology, 2017, 8, pp.2433. ⟨10.3389/fmicb.2017.02433⟩. ⟨hal-01911203⟩
26 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More