The clinical role of the TME in solid cancer - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue British Journal of Cancer Année : 2019

The clinical role of the TME in solid cancer

Résumé

The highly complex and heterogenous ecosystem of a tumour not only contains malignant cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts, and a variety of immune cells that control tumour growth and invasion. It is well established that anti-tumour immunity is a critical hurdle that must be overcome for tumours to initiate, grow and spread and that anti-tumour immunity can be modulated using current immunotherapies to achieve meaningful anti-tumour clinical responses. Pioneering studies in melanoma, ovarian and colorectal cancer have demonstrated that certain features of the tumour immune microenvironment (TME)-in particular, the degree of tumour infiltration by cytotoxic T cells-can predict a patient's clinical outcome. More recently, studies in renal cell cancer have highlighted the importance of assessing the phenotype of the infiltrating T cells to predict early relapse. Furthermore, intricate interactions with non-immune cellular players such as endothelial cells and fibroblasts modulate the clinical impact of immune cells in the TME. Here, we review the critical components of the TME in solid tumours and how they shape the immune cell contexture, and we summarise numerous studies evaluating its clinical significance from a prognostic and theranostic perspective.
Fichier principal
Vignette du fichier
s41416-018-0327-z.pdf (908.38 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01985551 , version 1 (18-01-2019)

Identifiants

Citer

Nicolas A Giraldo, Rafael Sanchez-Salas, J David Peske, Yann A Vano, Etienne Becht, et al.. The clinical role of the TME in solid cancer. British Journal of Cancer, 2019, 120 (1), pp.45-53. ⟨10.1038/s41416-018-0327-z⟩. ⟨hal-01985551⟩
70 Consultations
351 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More