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Article Dans Une Revue Glia Année : 2012

Cthrc1 is a negative regulator of myelination in Schwann cells

Résumé

The analysis of the molecular mechanisms involved in the initial interaction between neurons and Schwann cells is a key issue in understanding the myelination process. We recently identified Cthrc1 (Collagen triple helix repeat containing 1) as a gene upregulated in Schwann cells upon interaction with the axon. Cthrc1 encodes a secreted protein previously shown to be involved in migration and proliferation in different cell types. We performed a functional analysis of Cthrc1 in Schwann cells by loss- and gain-of-function approaches, using RNA interference knock-down in cell culture and a transgenic mouse line that overexpresses the gene. This work establishes that Cthrc1 enhances Schwann cell proliferation, but prevents myelination. In particular, time-course analysis of myelin formation in transgenic animals reveals that overexpression of Cthrc1 in Schwann cells leads to a delay in myelin formation, with cells maintaining a proliferative state. Our data therefore demonstrate that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination.

Domaines

Neurobiologie
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Dates et versions

hal-01991278 , version 1 (23-01-2019)

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Caroline Apra, Laurence Richard, Fanny Coulpier, Corinne Blugeon, Pascale Gilardi-Hebenstreit, et al.. Cthrc1 is a negative regulator of myelination in Schwann cells. Glia, 2012, 60 (3), pp.393-403. ⟨10.1002/glia.22273⟩. ⟨hal-01991278⟩

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