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Article Dans Une Revue BMC Cancer Année : 2015

Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

Résumé

Background: Ovarian granulosa cell tumors (GCTs) are the most frequent sex cord-stromal tumors. Several studies have shown that a somatic mutation leading to a C134W substitution in the transcription factor FOXL2 appears in more than 95% of adult-type GCTs. Its pervasive presence suggests that FOXL2 is the main cancer driver gene. However, other mutations and genomic changes might also contribute to tumor formation and/or progression.
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hal-02119186 , version 1 (03-05-2019)

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Sandrine Caburet, Mikko Anttonen, Anne-Laure Todeschini, Leila Unkila-Kallio, Denis Mestivier, et al.. Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes. BMC Cancer, 2015, 15 (1), ⟨10.1186/s12885-015-1283-0⟩. ⟨hal-02119186⟩
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