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Article Dans Une Revue Science Advances Année : 2019

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

Résumé

Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (T H 2) impaired IL-4R −/− offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived T H 2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.
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Dates et versions

hal-02179309 , version 1 (16-11-2020)

Identifiants

Citer

Matthew Darby, Alisha Chetty, Dunja Mrjden, Marion Rolot, Katherine L. Smith, et al.. Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. Science Advances , 2019, 5 (5), pp.eaav3058. ⟨10.1126/sciadv.aav3058⟩. ⟨hal-02179309⟩

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